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drug resistance

Open Access | PNAS Plus: Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

August 24, 2011 - 11:36 -- Kabogo Ndegwa
Author(s): 
Michael B. Harbut, Geetha Velmourougane, Seema Dalal, Gilana Reiss, James C. Whisstock, Ozlem Onder, Dustin Brisson, Sheena McGowan, Michael Klemba, and Doron C. Greenbaum
Reference: 
PNAS August 23, 2011 vol. 108 no. 34 E526-E534

Malaria causes worldwide morbidity and mortality, and while chemotherapy remains an excellent means of malaria control, drug-resistant parasites necessitate the discovery of new antimalarials.

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Open Access | Transmission Intensity and Drug Resistance in Malaria Population Dynamics: Implications for Climate Change

October 30, 2010 - 12:39 -- Kabogo Ndegwa
Author(s): 
Yael Artzy-Randrup, David Alonso, Mercedes Pascual
Reference: 
PLoS ONE 5(10): e13588

Although the spread of drug resistance and the influence of climate change on malaria are most often considered separately, these factors have the potential to interact through altered levels of transmission intensity.

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Open Access | Drug coverage in treatment of malaria and the consequences for resistance evolution - evidence from the use of sulphadoxine/pyrimethamine

July 6, 2010 - 06:52 -- Kabogo Ndegwa
Author(s): 
Malisa AL, Pearce RJ, Abdulla S, Mshinda H, Kachur PS, Bloland P, Roper C
Reference: 
Malaria Journal 2010, 9:190 (5 July 2010)

The national policy change brought about a shift in treatment practice and the resulting increase in coverage had a substantial impact on drug pressure.

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Editorial: Do post-disaster public health interventions impede malaria eradication?

February 13, 2010 - 11:53 -- Kabogo Ndegwa
Author(s): 
Philip Weinstein, James Goff, and Chris Skelly
Reference: 
Medical Hypotheses, Volume 74, Issue 3, March 2010, Pages 403-405

In this paper, we hypothesise that public health interventions aimed at controlling post-disaster malaria epidemics may in fact impede malaria eradication efforts in the longer term.

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A molecular map of chloroquine resistance in Mali

January 10, 2010 - 16:54 -- Ingeborg van Schayk
Author(s): 
A. A. Djimde, B. Barger, A. Kone, A. H. Beavogui, M. Tekete, B. Fofana, A. Dara, H. Maiga, D. Dembele, S. Toure, S. Dama, D. Ouologuem, C. P. O. Sangare, A. Dolo, N. Sogoba, K. Nimaga, Y. Kone & O. K. Doumbo
Reference: 
FEMS Immunology & Medical Microbiology, Early View (Articles online in advance of print)

We present a comprehensive map of CQR in Mali, which strongly supports recent changes in drug policy away from chloroquine.

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Short communication: Absence of an impact of resistance to chloroquine on consultations for malaria in Niakhar, Senegal (1992–2004)

November 26, 2009 - 06:50 -- Kabogo Ndegwa
Author(s): 
A. Munier, A. Diallo, J.P. Chippaux
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1288-1290, doi:10.1016/j.trstmh.2009.03.017

We retrospectively assessed the impact of chloroquine (CQ) resistance in the rural region of Niakhar, Senegal, where resistance to CQ emerged in 1992, from increases in consultations and returns of patients to the health centre following antimalarial treatment.

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