A significant intersection between antimalarial and antiprion activity is well established for certain compound classes, specifically for polycyclic antimalarial agents bearing basic nitrogen-containing sidechains (e.g., chloroquine, quinacrine, mefloquine).
Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 12, 15 June 2011, Pages 3644-3647
The Journal of Immunology April 15, 2011 vol. 186 no. 8 4794-4804
Endosomal TLRs play an important role in innate immune response as well as in autoimmune processes.