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quinacrine

2,4-Diarylthiazole antiprion compounds as a novel structural class of antimalarial leads

June 2, 2011 - 07:06 -- Kabogo Ndegwa
Author(s): 
Mark J. Thompson, Jennifer C. Louth, Susan M. Little, Beining Chen, Iain Coldham
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 12, 15 June 2011, Pages 3644-3647

A significant intersection between antimalarial and antiprion activity is well established for certain compound classes, specifically for polycyclic antimalarial agents bearing basic nitrogen-containing sidechains (e.g., chloroquine, quinacrine, mefloquine).

Medical Condition: 

Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

April 7, 2011 - 07:15 -- Kabogo Ndegwa
Author(s): 
Alenka Kuznik, Mojca Bencina, Urban Svajger, Matjaz Jeras, Blaz Rozman, and Roman Jerala
Reference: 
The Journal of Immunology April 15, 2011 vol. 186 no. 8 4794-4804

Endosomal TLRs play an important role in innate immune response as well as in autoimmune processes.

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