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Open Access | Development of the piggyBac transposable system for Plasmodium berghei and its application for random mutagenesis in malaria parasites

March 22, 2011 - 13:10 -- Patrick Sampao
Jannik Fonager, Blandine MD Franke-Fayard , John H. Adams, Jai Ramesar, Onny Klop, Shahid M. Khan, Chris J. Janse and Andrew P. Waters
BMC Genomics 2011, 12:155

This study reports the development and application of the piggyBac transposition system for the rodent malaria parasite P. berghei and the evaluation of its potential as a tool in forward genetic studies. P. berghei is the most frequently used malaria parasite model in gene function analysis since phenotype screens throughout the complete Plasmodium life cycle are possible both in vitro and in vivo.

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