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de novo

Plasmodium salvages cholesterol internalized by LDL and synthesized de novo in the liver

March 21, 2011 - 06:54 -- Patrick Sampao
Mehdi Labaied, Bamini Jayabalasingham, Nazneen Bano, Sung-Jae Cha, Juan Sandoval, Guimin Guan, Isabelle Coppens
Cellular Microbiology, Volume 13, Issue 4, pages 569–586, April 2011

These data enlighten that, on one hand, malaria parasites have moderate need of sterols for optimal development in hepatocytes and, on the other hand, they can adapt to survive in cholesterol-restrictive conditions by exploitation of accessible sterols derived from alternative sources in hepatocytes to maintain proper infectivity.

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