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mefloquine (MQ)

Monitoring PfMDR1 transport in Plasmodium falciparum

July 14, 2015 - 09:25 -- Open Access
Author(s): 
Sarah J Reiling, Petra Rohrbach
Reference: 
Malaria Journal 2015, 14:270 (15 July 2015)

This study demonstrates that Fluo-4 can be used to investigate PfMDR1 transport dynamics in both drug-sensitive and -resistant parasites.

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Effect of artesunate-mefloquine fixed-dose combination in malaria transmission in amazon basin communities

August 23, 2012 - 06:43 -- Kabogo Ndegwa
Author(s): 
Santelli AC, Ribeiro I, Daher A, Boulos M, Marchesini PB, La Corte dos Santos R, Lucena MB, Magalhães I, Leon AP, Junger W, Ladislau JL
Reference: 
Malaria Journal 2012, 11:286 (20 August 2012)

MalariaWorldIn the remote region of the Jurua valley, the early detection of malaria by health care workers and treatment with fixed-dose ASMQ was feasible and efficacious, and significantly reduced the incidence and morbidity of P. falciparum malaria.

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Effect of artesunate and mefloquine in combination on the Fridericia corrected QT intervals in Plasmodium falciparum infected adults from Thailand

March 17, 2011 - 08:49 -- Kabogo Ndegwa
Author(s): 
S. Krudsood, S. Looareesuwan, P. Wilairatama, W. Leowattana, N. Tangpukdee, K. Chalermrut, S. Ramanathan, V. Navaratnam, P. Olliaro, M. Vaillant, J. R. Kiechel and W. R. J. Taylor
Reference: 
Tropical Medicine & International Health, Volume 16, Issue 4, pages 458–465, April 2011

In this small group of patients, slowing heart rates due to malaria resolution best explained the observed increases in the QTcF intervals.

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