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antigen 1

Long-Term Humoral and Cellular Immune Responses Elicited by a Heterologous Plasmodium vivax Apical Membrane Antigen 1 Protein Prime/Adenovirus Boost Immunization Protocol

September 8, 2011 - 09:14 -- Patrick Sampao
Author(s): 
Leoneide Érica Maduro Bouillet, Mariana Oliveira Dias, Oscar Bruna-Romero, et al.
Reference: 
Infect. Immun., Sep 2011; 79: 3642 - 3652.

We show here that when it is administered as a recombinant protein (P) in Montanide ISA720 adjuvant, followed by a recombinant human type 5 adenovirus (Ad), intense and long-lasting Plasmodium vivax AMA-1-specific antibody responses (including both IgG1 and IgG2a), as well as proliferative memory T cell responses, can be detected in immunized mice.

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Apical Membrane Antigen 1 as an Anti-Malarial Drug Target

August 3, 2011 - 09:02 -- Patrick Sampao
Author(s): 
A. MacRaild, Christopher; F. Anders, Robin; Foley, Michael; S. Norton, Raymond
Reference: 
Current Topics in Medicinal Chemistry, Volume 11, Number 16, August 2011 , pp. 2039-2047(9)

Here we review both the structural details and functional significance of interactions at the hydrophobic cleft of AMA1, and argue that this feature of the protein represents an excellent target for the development of drugs that would block host cell invasion by malarial parasites.

Peptide inhibitors of the malaria surface protein, apical membrane antigen 1: Identification of key binding residues

March 15, 2011 - 14:06 -- Patrick Sampao
Author(s): 
Erinna F. Lee., Shenggen Yao., Raymond S. Norton., et al.
Reference: 
Biopolymers, Volume 95, Issue 5, pages 354–364, May 2011

The peptide was expressed as a fusion protein following replacement of Met16 by Leu in order to accommodate cyanogen bromide cleavage. This modified peptide (R2) displayed the same affinity for AMA1 as R1, showing that the identity of the side chain at position 16 was not critical for binding.

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