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antitubercular agents

Novel thiolactone–isatin hybrids as potential antimalarial and antitubercular agents

March 15, 2011 - 08:15 -- Kabogo Ndegwa
Author(s): 
Renate H. Hans, Ian J.F. Wiid, Paul D. van Helden, Baojie Wan, Scott G. Franzblau, Jiri Gut, Philip J. Rosenthal, Kelly Chibale
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 7, 1 April 2011, Pages 2055-2058

The synthesis of a novel series of thiolactone–isatin hybrids led to the discovery of tetracyclic by-products which displayed superior antiplasmodial activity.

Medical Condition: 
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