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artemisinin-aminoquinoline

Synthesis, in vitro antimalarial and cytotoxicity of artemisinin-aminoquinoline hybrids

March 9, 2011 - 08:13 -- Kabogo Ndegwa
Author(s): 
Marli C. Lombard, David D. N’Da, Jaco C. Breytenbach, Peter J. Smith, Carmen A. Lategan
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 6, 15 March 2011, Pages 1683-1686c

Dihydroartemisinin (DHA) was coupled to different aminoquinoline moieties forming hybrids 9–14, which were then treated with oxalic acid to form oxalate salts (9a–14a).

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