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vaccination

Effect of ingested human antibodies induced by RTS, S/AS01 malaria vaccination in children on Plasmodium falciparum oocyst formation and sporogony in mosquitoes

July 22, 2014 - 08:58 -- Open Access
Author(s): 
Miura K, Jongert E, Deng B, Zhou L, Lusingu JP, Drakeley CJ, Fay MP, Long CA, Vekemans J
Reference: 
Malaria Journal 2014, 13 :263 (9 July 2014)

This study does not support the concept that anti-CS antibodies induced by the RTS,S/AS01 vaccines in humans noticeably reduce malaria transmission by blocking P. falciparum sporozoite development or salivary gland invasion in mosquitoes when taken up during feeding.

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GCE Special: Production of a transgenic mosquito, as a flying syringe, to deliver protective vaccine via saliva

May 27, 2013 - 19:15 -- Bart G.J. Knols
Author(s): 
Hiroyuki Matsuoka
Reference: 
MWJ 2013, 4, 4

In this GCE project it was aimed to put a gene encoding a pathogen protein into a mosquito chromosome, causing it to express the protein in its saliva and inject it into animals orhumans during the blood-feeding process. It was anticipated that the host would develop antibodies to the recombinant protein. If transgenic mosquitoes whose saliva contained a vaccine protein against a disease are released in an area where the disease is prevalent, people that are bitten daily by these mosquitoes would develop antibodies to the vaccine protein, and ultimately the entire community would be ‘vaccinated’ against the disease. In this situation, mosquitoes would play the role of vaccine deliverers.

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Restricted | Whole parasite vaccination approaches for prevention of malaria infection

May 4, 2012 - 14:08 -- Patrick Sampao
Author(s): 
Noah S. Butler, Ashley M. Vaughan, John T. Harty, Stefan H.I. Kappe
Reference: 
Trends in Immunology, Volume 33, Issue 5, May 2012, Pages 247-254

MalariaWorldThis model gave the rationale for development of recombinant and vectored subunit vaccination strategies that have, however, not yet matched whole sporozoite protective efficacy.

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Optimal control analysis of a malaria disease transmission model that includes treatment and vaccination with waning immunity

November 16, 2011 - 08:57 -- Patrick Sampao
Author(s): 
K.O. Okosun, Rachid Ouifki, Nizar Marcus
Reference: 
Biosystems, Volume 106, Issues 2-3, November-December 2011, Pages 136-145

MalariaWorldThe results obtained from the numerical simulations of the model show that a possible vaccination combined with effective treatment regime would reduce the spread of the disease appreciably.

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My malaria control view

July 27, 2011 - 14:12 -- Jacques Drolet

Immuno-therapy is to therapeutic treatments what vector modification is to vector control. In other words, increasing the self-defense potential of either humans or mosquitoes is addressing the source of the problem for humans and for mosquitoes, both approaches giving a fundamentally hard time to Plasmo. Although I think that techniques like impregnated nets and breeding site reduction will continue to be needed, giving humans (vaccination) and mosquitoes (popcorn wolbachia) the means to fight back Plasmo is leading the true way out of malaria.

Open Access | Malaria infection by sporozoite challenge induces high functional antibody titres against blood stage antigens after a DNA prime, poxvirus boost vaccination strategy in Rhesus macaques

February 10, 2011 - 06:56 -- Kabogo Ndegwa
Author(s): 
Mahdi Abdel Hamid M, Remarque EJ, El Hassan IM, Hussain AA, Narum DL, Thomas AW, Kocken CH, Weiss WR, Faber BW
Reference: 
Malaria Journal 2011, 10:29 (8 February 2011)

This is the first report that demonstrates that a DNA prime/poxvirus boost vaccination regimen induces low levels of malaria parasite growth inhibitory antibodies, which are boosted to high levels upon challenge.

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Selection and identification of malaria vaccine target molecule using bioinformatics and DNA vaccination

September 22, 2010 - 14:31 -- Patrick Sampao
Author(s): 
M.N. Shuaibu, M. Kikuchi, M.S. Cherif, G.K. Helegbe, T. Yanagi, K. Hirayama
Reference: 
Vaccine, Volume 28, Issue 42, 4 October 2010, Pages 6868-6875

Focusing on the blood stage, we extracted mRNA from pRBCs, PCR-amplified 22 out of the 29 selected genes, and eventually cloned nine of these into a DNA vaccine plasmid, pVAX 200-DEST.

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Empowering malaria vaccination by drug administration

June 8, 2010 - 09:50 -- Kabogo Ndegwa
Author(s): 
Robert W Sauerwein, Else M Bijker, Thomas L Richie
Reference: 
Current Opinion in Immunology, Volume 22, Issue 3, June 2010, Pages 367-373

Although significant progress has been made in clinical development, a protective malaria vaccine remains elusive. Here we review some of the immune subversive mechanisms used by the Plasmodium malaria parasite and propose a potentially effective strategy to achieve complete protection that may serve as a blue print for clinical usage.

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Short communication: Vaccination with recombinant Plasmodium vivax MSP-10 formulated in different adjuvants induces strong immunogenicity but no protection

April 22, 2010 - 11:25 -- Patrick Sampao
Author(s): 
Manuel A. Giraldo, Gabriela Arevalo-Pinzon, Jose Rojas-Caraballo, Alvaro Mongui, Raul Rodriguez, Manuel A. Patarroyo
Reference: 
Vaccine, Volume 28, Issue 1, 10 December 2009, Pages 7-13

The immunogenicity of rPvMSP10 was tested in Aotus monkeys, comparing responses induced by formulations with Freund's adjuvant, Montanide ISA720 or aluminum hydroxide.

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Open Access | Prime-Boost Immunization with Adenoviral and Modified Vaccinia Virus Ankara Vectors Enhances the Durability and Polyfunctionality of Protective Malaria CD8+ T-Cell Responses

January 10, 2010 - 14:29 -- Ingeborg van Schayk
Author(s): 
Arturo Reyes-Sandoval, Tamara Berthoud, Nicola Alder, Loredana Siani, Sarah C. Gilbert, Alfredo Nicosia, Stefano Colloca, Riccardo Cortese, and Adrian V. S. Hill
Reference: 
Infect. Immun. 2010;78 145-153 Open Access

These data highlight the ability of optimized viral vector prime-boost regimens to generate more protective and sustained CD8+ T-cell responses, and our results encourage a more nuanced assessment of the importance of inducing polyfunctional CD8+ T cells by vaccination.

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