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A single dose combination study with the experimental antimalarials artefenomel and DSM265 to determine safety and antimalarial activity against blood-stage Plasmodium falciparum in healthy volunteers

November 8, 2019 - 16:44 -- Open Access
Author(s): 
McCarthy J, Rückle T, Elliott SL, Ballard E, Collins KA, Marquart L, Griffin P, Chalon S, Möhrle JJ
Reference: 
Antimicrob Agents Chemother. 2019 Nov 4

Artefenomel and DSM265 are two new compounds that have been shown to be well tolerated and effective when administered as monotherapy malaria treatment. This study aimed to determine the safety, pharmacokinetics and pharmacodynamics of artefenomel and DSM265 administered in combination to healthy subjects in a volunteer infection study using the Plasmodium falciparum induced blood stage malaria model. 

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Corrigendum: Chronic Exposure to Malaria Is Associated with Inhibitory and Activation Markers on Atypical Memory B Cells and Marginal Zone-Like B Cells

November 7, 2019 - 22:03 -- Open Access
Author(s): 
Ubillos I, Campo JJ, Requena P, Ome-Kaius M, Hanieh S, Rose H, Samol P, Barrios D, Jiménez A, Bardají A, Mueller I, Menéndez C, Rogerson S, Moncunill G, Dobaño C.
Reference: 
Front Immunol. 2019 Oct 17;10:2427 (eCollection 2019)

In the original article, we neglected to include the co-funder “FEDER funds/European Regional Development Fund (ERDF)” to “Instituto de Salud Carlos III (grant number PI14/01422)”.

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A Viral-Vectored Multi-Stage Malaria Vaccine Regimen With Protective and Transmission-Blocking Efficacies

November 7, 2019 - 21:56 -- Open Access
Author(s): 
Yusuf Y, Yoshii T, Iyori M, Mizukami H, Fukumoto S, Yamamoto DS, Emran TB, Amelia F, Islam A, Syafira I, Yoshida S
Reference: 
Front Immunol. 2019 Oct 15;10:2412 (eCollection 2019)

Malaria parasites undergo several stages in their complex lifecycle. To achieve reductions in both the individual disease burden and malaria transmission within communities, a multi-stage malaria vaccine with high effectiveness and durability is a more efficacious strategy compared with a single-stage vaccine.

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Not Open Access | Imported malaria and artemisinin-based combination therapy failure in travellers returning to Belgium: A retrospective study

November 7, 2019 - 21:48 -- NOT Open Access
Author(s): 
Rovira-Vallbona E, Bottieau E, Guetens P, Verschueren J, Rebolledo J, Nulens E, Van der Hilst J, Clerinx J, Van Esbroeck M, Rosanas-Urgell A
Reference: 
Travel Med Infect Dis. 2019 Oct 30:101505 [Epub ahead of print]

BACKGROUND

Malaria (Plasmodium spp) remains a top cause of travel-associated morbidity among European residents. Here, we describe recent trends of imported malaria to Belgium and characterize the first cases of P.falciparum failure to artemisinin combination therapy (ACT).

METHODS

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Not Open Access | First report of Glucose-6-phosphate dehydrogenase (G6PD) variants (Mahidol and Acores) from malaria-endemic regions of northeast India and their functional evaluations in silico

November 7, 2019 - 21:44 -- NOT Open Access
Author(s): 
Bharti RS, Vashisht K, Ahmed N, Nayak A, Pande V, Mishra N
Reference: 
Acta Trop. 2019 Oct 31:105252 [Epub ahead of print]

G6PD deficiency results from numerous mutations in the G6PD gene and can cause alterations in enzyme function up to varying degrees. P. vivax malaria infections require G6PD deficiency screening because of the potential risk of haemolysis by the gametocytocidal drug (primaquine) during the radical treatment.

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Comparison of whole blood and spleen transcriptional signatures over the course of an experimental malaria infection

November 7, 2019 - 21:37 -- Open Access
Author(s): 
Talavera-López C, Bediako Y, Lin JW, Joseph Valletta J, Recker M, Langhorne J
Reference: 
Sci Rep. 2019 Nov 1;9(1):15853

Although the spleen is broadly accepted as the major lymphoid organ involved in generating immune responses to the erythrocytic stages of the malaria parasite, Plasmodium, human splenic tissue is not readily available in most cases.

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Not Open Access | The regulation of CD4+ T cells during malaria

November 7, 2019 - 21:31 -- NOT Open Access
Author(s): 
Kumar R, Loughland JR, Ng SS, Boyle MJ, Engwerda CR
Reference: 
Immunol Rev. 2019 Nov 1

Malaria is a major global health problem. Despite decades of research, there is still no effective vaccine to prevent disease in the majority of people living in malaria-endemic regions.

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Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

November 7, 2019 - 21:20 -- Open Access
Author(s): 
Lindner SE, Swearingen KE, Shears MJ, Walker MP, Vrana EN, Hart KJ, Minns AM, Sinnis P, Moritz RL, Kappe SHI
Reference: 
Nat Commun. 2019 Oct 31;10(1):4964

Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must navigate the host skin and vasculature to infect the liver. This journey requires distinct proteomes.

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A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria

November 7, 2019 - 21:12 -- Open Access
Author(s): 
Birbeck GL, Herman ST, Capparelli EV, Dzinjalamala FK, Abdel Baki SG, Mallewa M, Toto NM, Postels DG, Gardiner JC, Taylor TE, Seydel KB
Reference: 
BMC Pediatr. 2019 Nov 1;19(1):399

BACKGROUND

Acute seizures are common in pediatric cerebral malaria (CM), but usual care with phenobarbital risks respiratory suppression. We undertook studies of enteral levetiracetam (eLVT) to evaluate pharmacokinetics (PK), safety and efficacy including an open-label, randomized controlled trial (RCT) comparing eLVT to phenobarbital.

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