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cerebral

Not Open Access | Metabolic Fingerprints of Serum, Brain, and Liver Are Distinct for Mice with Cerebral and Noncerebral Malaria: A 1H NMR Spectroscopy-Based Metabonomic Study

August 29, 2012 - 15:29 -- Patrick Sampao
Author(s): 
Soumita Ghosh, Arjun Sengupta, Shobhona Sharma, and Haripalsingh M. Sonawat
Reference: 
J. Proteome Res., July 27, 2012

MalariaWorldThe objective of this study was to search for metabolic changes/fingerprints of CM and identify the pathways that might be differentially altered in mice that succumbed to CM. The results show that brain, liver, and sera exhibit unique metabolic fingerprints for CM over NCM mice.

Differential MicroRNA Expression in Experimental Cerebral and Noncerebral Malaria

May 19, 2011 - 09:23 -- Patrick Sampao
Author(s): 
Fatima El-Assaad, Casper Hempel, Valéry Combes, Andrew J. Mitchell, Helen J. Ball, Jørgen A. L. Kurtzhals, Nicholas H. Hunt, Jean-Marie Mathys, and Georges E. R. Grau
Reference: 
Infect. Immun., Jun 2011; 79: 2379 - 2384.

To investigate the involvement of let-7i, miR-27a, and miR-150 in CM-resistant mice, we assessed the expression levels in gamma interferon knockout (IFN-{gamma}–/–) mice on a C57BL/6 genetic background.

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PPAR-gamma agonists for the treatment of cerebral malaria - tweaking the host response to save brains

April 7, 2011 - 14:48 -- Lena Serghides

Even when treated with the best anti-malaria drugs 1 in 5 children with cerebral malaria will die, and of the survivors 1 in 4 will be left with long-term learning and memory impairment. This is because the host response to the infection plays as much a role in contributing to the development of cerebral malaria as does the parasite itself. Although conventional therapies for malaria can be very effective at eliminating the parasite, they do little to modulate the host response.

Open Access | Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF

January 18, 2011 - 08:12 -- Patrick Sampao
Author(s): 
Samuel Crocodile Wassmer, Christopher Alan Moxon, Terrie Taylor, Georges Emile Grau, Malcolm Edward Molyneux,Alister Gordon Craig
Reference: 
Cellular Microbiology,Volume 13, Issue 2, pages 198–209, February 2011

These data suggest that inter-individual differences in the endothelial inflammatory response to TNF may be an additional factor influencing the clinical course of malaria.

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Open Access | The Platelet Count in Cerebral Malaria, Is It Useful to the Clinician?

July 2, 2010 - 10:19 -- Patrick Sampao
Author(s): 
Yamikani Chimalizeni, Kondwani Kawaza, Terrie Taylor, and Malcolm Molyneux
Reference: 
Am. J. Trop. Med. Hyg., 83(1), 2010, pp. 48-50

We studied children with cerebral malaria admitted to the pediatric research ward at Queen Elizabeth Central Hospital, Malawi. We analyzed 1,811 children with cerebral malaria and compared them with 521 children with bacterial meningitis.

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Open Access | Transforming Growth Factor Beta 2 and Heme Oxygenase 1 Genes Are Risk Factors for the Cerebral Malaria Syndrome in Angolan Children

June 18, 2010 - 11:23 -- Kabogo Ndegwa
Author(s): 
Maria Rosário Sambo, Maria Jesus Trovoada, Carla Benchimol, Vatúsia Quinhentos, Lígia Gonçalves, Rute Velosa, Maria Isabel Marques, Nuno Sepúlveda, Taane G. Clark, Stefan Mustafa, Oswald Wagner, António Coutinho, Carlos Penha-Gonçalves
Reference: 
PLoS ONE 5(6): e11141.

These results represent the first report on CM genetic risk factors in Angolan children and suggest the novel hypothesis that genetic variants of the TGFB2 and HMOX1 genes may contribute to confer a specific risk of developing the CM syndrome in patients with severe P. falciparum malaria.

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Open Access | Cerebral malaria: insights from host-parasite protein-protein interactions

June 11, 2010 - 07:10 -- Patrick Sampao
Author(s): 
Rao A, Kumar MK, Joseph T, Bulusu G
Reference: 
Malaria Journal 2010, 9:155 (9 June 2010)

This work links key host-parasite, parasite-parasite and host-host protein-protein interactions to key processes of cerebral malaria and generates hypotheses for disease pathogenesis based on a filtered interaction dataset.

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Clinical Picture: Malarial retinopathy and fluorescein angiography findings in a Malawian child with cerebral malaria

May 25, 2010 - 13:18 -- Patrick Sampao
Author(s): 
Simon J Glover, Richard J Maude, Terrie E Taylor, Malcolm E Molyneux, Nicholas AV Beare
Reference: 
The Lancet Infectious Diseases, Volume 10, Issue 6, June 2010, Page 440

No abstract available

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Short communication: IFNGR1 polymorphisms in Thai malaria patients

November 26, 2009 - 06:50 -- Patrick Sampao
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Author(s): 
Izumi Naka, Jintana Patarapotikul, Hathairad Hananantachai, Katsushi Tokunaga, Naoyuki Tsuchiya, Jun Ohashi
Reference: 
Infection, Genetics and Evolution, Volume 9, Issue 6, December 2009, Pages 1406-1409, doi:10.1016/j.meegid.2009.08.004

Interferon-γ (IFN-γ) has been suggested to play an important role in the pathogenesis of malaria.

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Plasmodium falciparum–infected erythrocytes induce NF-{kappa}B regulated inflammatory pathways in human cerebral endothelium

November 13, 2009 - 08:51 -- Ingeborg van Schayk
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Author(s): 
Abhai K. Tripathi, Wei Sha, Vladimir Shulaev, Monique F. Stins, and David J. Sullivan, Jr
Reference: 
Blood, 5 November 2009, Vol. 114, No. 19, pp. 4243-4252, DOI 10.1182/blood-2009-06-226415

Because the brain endothelium is at the interface of these processes, we investigated the global gene responses of human brain endothelium after the interaction with Plasmodium falciparum–infected erythrocytes with either high- or low-binding phenotypes.

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