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Not Open Access | Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold

November 25, 2012 - 14:20 -- NOT Open Access
Vanida Choomuenwai, Katherine T. Andrews, Rohan A. Davis
Bioorganic & Medicinal Chemistry, Volume 20, Issue 24, 15 December 2012, Pages 7167-7174

This compound displayed moderate cytotoxicity against neonatal foreskin fibroblast (NFF) cells with an IC50 of 15.6 μM.

Review: PfCRT and its role in antimalarial drug resistance

October 23, 2012 - 11:19 -- Patrick Sampao
Andrea Ecker, Adele M. Lehane, Jérôme Clain, David A. Fidock
Trends in Parasitology, Volume 28, Issue 11, November 2012, Pages 504-514

MalariaWorldThese results highlight the need to be vigilant in screening for the appearance of novel pfcrt alleles that could contribute to new multi-drug resistance phenotypes.

Medical Condition: 

Open Access | Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum

May 17, 2010 - 09:12 -- Kabogo Ndegwa
Stephanie G. Valderramos, Juan-Carlos Valderramos, Lise Musset, Lisa A. Purcell, Odile Mercereau-Puijalon, Eric Legrand, David A. Fidock
PLoS Pathog 6(5): e1000887.

Mutant forms of the Plasmodium falciparum transporter PfCRT constitute the key determinant of parasite resistance to chloroquine (CQ), the former first-line antimalarial, and are ubiquitous to infections that fail CQ treatment.

Open Access | Review: Malaria in Brazil: an overview

May 3, 2010 - 09:36 -- Kabogo Ndegwa
Oliveira-Ferreira J, Lacerda MV, Brasil P, Ladislau JL, Tauil PL, Daniel-Ribeiro CT
Malaria Journal 2010, 9:115 (30 April 2010)

Malaria is still a major public health problem in Brazil, with approximately 306,000 registered cases in 2009, but it is estimated that in the early 1940s, around six million cases of malaria occurred each year.


Inaugural Article: Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine

November 11, 2009 - 10:16 -- Ingeborg van Schayk
Juliana Martha Sá, Olivia Twu, Karen Hayton, Sahily Reyes, Michael P. Fay, Pascal Ringwald, and Thomas E. Wellems
PNAS November 10, 2009 vol. 106 no. 45 18883-18889

Increasing use of AQ in Africa poses the threat of a selective sweep of highly AQ-resistant, CQ-resistant parasites with pfcrt and pfmdr1 mutations that are as advantaged and persistent as in South America.


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