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merozoites

Open Access | Highly Dynamic Host Actin Reorganization around Developing Plasmodium Inside Hepatocytes

January 17, 2012 - 06:50 -- Kabogo Ndegwa
Author(s): 
Carina S. S. Gomes-Santos, Maurice A. Itoe, Maria M. Mota, et al.
Reference: 
PLoS ONE 7(1): e29408

MalariaWorldPlasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole.

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Open Access | Exposure of the Plasmodium falciparum clonally variant STEVOR proteins on the merozoite surface

March 15, 2011 - 08:35 -- Kabogo Ndegwa
Author(s): 
Khattab A, Meri S
Reference: 
Malaria Journal 2011, 10:58 (14 March 2011)

These data suggest for a role for STEVOR in immune evasion by P. falciparum merozoites to allow successful invasion of erythrocytes.

Plasmodium falciparum: Differing effects of non-esterified fatty acids and phospholipids on intraerythrocytic growth in serum-free medium

February 24, 2011 - 07:41 -- Kabogo Ndegwa
Author(s): 
Hiroko Asahi, Shinji Izumiyama, Mohammed Essa Marghany Tolba, Bethel Kwansa-Bentum
Reference: 
Experimental Parasitology, Volume 127, Issue 3, March 2011, Pages 708-713

Different combinations of non-esterified fatty acids (NEFA) had variable effects on intraerythrocytic growth of Plasmodium falciparum.

A retrospective evaluation of the role of T cells in the development of malaria vaccine

September 10, 2010 - 13:13 -- Kabogo Ndegwa
Author(s): 
Moriya Tsuji
Reference: 
Experimental Parasitology, Volume 126, Issue 3, November 2010, Pages 421-425

Due to the fact that the life cycle of malaria parasites is complex, undergoing both an extracellular and intracellular phases in its host, the human immune system has to mobilize both the humoral and cellular arms of immune responses to fight against this parasitic infection.

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Short Communication: Localization of apical sushi protein in Plasmodium falciparum merozoites

August 23, 2010 - 13:54 -- Patrick Sampao
Author(s): 
Anand Srivastava, Shailja Singh, Shikha Dhawan, M. Mahmood Alam, Asif Mohmmed, Chetan E. Chitnis
Reference: 
Molecular and Biochemical Parasitology, Volume 174, Issue 1, November 2010, Pages 66-69

In the present study, we have used indirect immunofluorescence assays and immunoelectron microscopy to demonstrate that PfASP is localized in the neck of rhoptries and not in micronemes as previously described.

Red Cells, Iron, and Erythropoiesis: Interactions with heparin-like molecules during erythrocyte invasion by Plasmodium falciparum merozoites

June 7, 2010 - 09:06 -- Patrick Sampao
Author(s): 
Michelle J. Boyle, Jack S. Richards, Paul R. Gilson, Wengang Chai, and James G. Beeson
Reference: 
Blood, Jun 2010; 115: 4559 - 4568.

All P falciparum isolates tested, and parasites using different invasion pathways were inhibited to comparable levels. Furthermore, it was not possible to select for heparin-resistant parasites. Heparin-like molecules occur naturally on the surface of human erythrocytes, where they may act as receptors for binding of merozoite surface proteins.

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