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Open Access | Malaria IMC1 Membrane Skeleton Proteins Operate Autonomously and Participate in Motility Independently of Cell Shape

February 15, 2011 - 12:04 -- Patrick Sampao
Annie Z. Tremp and ,Johannes T. Dessens
The Journal of Biological Chemistry, February 18, 2011 286, 5383-5391.

We show here that a third family member, IMC1h, has a distinct differential expression pattern and localizes to the pellicle of both ookinetes and sporozoites. Knock-out of IMC1h mimics the loss-of-function phenotypes of IMC1a and IMC1b in their respective life stages, indicating that IMC1 proteins could be operating co-dependently.

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Review: An update on the rapid advances in malaria parasite cell biology

May 31, 2010 - 13:35 -- Patrick Sampao
Isabelle Coppens, David J. Sullivan, Sean T. Prigge
Trends in Parasitology, Volume 26, Issue 6, June 2010, Pages 305-310

We focus on three aspects of parasite cell biology: (i) plastid metabolism, (ii) sporozoite biology, and (iii) protein transport to and from the host erythrocyte. In each case recent work has led to a deeper understanding of parasite biology, often at the expense of previously accepted paradigms.

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Cellular Immunology and Immune Regulation: Cross-Talk between T Cells and NK Cells Generates Rapid Effector Responses to Plasmodium falciparum-Infected Erythrocytes

May 31, 2010 - 12:22 -- Kabogo Ndegwa
Amir Horowitz, Kirsty C. Newman, J. Henry Evans, Daniel S. Korbel, Daniel M. Davis, and Eleanor M. Riley
J. Immunol., Jun 2010; 184: 6043 – 6052

Rapid cell-mediated immune responses, characterized by production of proinflammatory cytokines, such as IFN-{gamma}, can inhibit intraerythrocytic replication of malaria parasites and thereby prevent onset of clinical malaria.

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