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Open Access | Extreme CD8 T Cell Requirements for Anti-Malarial Liver-Stage Immunity following Immunization with Radiation Attenuated Sporozoites

July 19, 2010 - 08:42 -- Kabogo Ndegwa
Nathan W. Schmidt, Noah S. Butler, Vladimir P. Badovinac, John T. Harty
PLoS Pathog 6(7): e1000998

Radiation-attenuated Plasmodium sporozoites (RAS) are the only vaccine shown to induce sterilizing protection against malaria in both humans and rodents.

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Open Access | Identification of a major rif transcript common to gametocytes and sporozoites of Plasmodium falciparum

May 31, 2010 - 12:03 -- Kabogo Ndegwa
Wang CW, Mwakalinga SB, Sutherland CJ, Schwank S, Sharp S, Hermsen CC, Sauerwein RW, Theander TG, Lavstsen T
Malaria Journal 2010, 9:147 (28 May 2010)

The most prominent variant surface antigen transcribed in both gametocytes and sporozoites of 3D7/NF54 is a single variant of the RIFIN protein family. This discovery may lead to the identification of the parasites binding ligands responsible for the adhesion during sexual stages and potentially to novel vaccine candidates.

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