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sporozoites

Open Access | Plasmodium Protease ROM1 Is Important for Proper Formation of the Parasitophorous Vacuole

September 7, 2011 - 06:56 -- Kabogo Ndegwa
Author(s): 
Iset Medina Vera, Wandy L. Beatty, Photini Sinnis, Kami Kim
Reference: 
PLoS Pathog 7(9): e1002197

Apicomplexans are obligate intracellular parasites that invade host cells by an active process leading to the formation of a non-fusogenic parasitophorous vacuole (PV) where the parasite replicates within the host cell.

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Early Transcriptional Responses of HepG2-A16 Liver Cells to Infection by Plasmodium falciparum Sporozoites

July 26, 2011 - 13:06 -- Patrick Sampao
Author(s): 
Rana Chattopadhyay, Patricia de la Vega, Sun H. Paik, Yoko Murata, Earl W. Ferguson, Thomas L. Richie and Guck T. Ooi
Reference: 
The Journal of Biological Chemistry, 286, 26396-26405, July 29, 2011

Our results show that as early as 30 min following wild-type, non-irradiated sporozoite exposure, the expressions of at least 742 genes was selectively altered.

Open Access | Activation of the hypnozoite: a part of Plasmodium vivax life cycle and survival

April 23, 2011 - 07:33 -- Kabogo Ndegwa
Author(s): 
Lena Hulden, Larry Hulden
Reference: 
Malaria Journal 2011, 10:90 (16 April 2011)

Artificial triggering of hypnozoites would make the medication more effective and resistance against a protein that the parasite itself uses during its life cycle would not develop.

Open Access | Intradermal immunization of mice with radiation-attenuated sporozoites of Plasmodium yoelii induces effective protective immunity

December 16, 2010 - 12:15 -- Kabogo Ndegwa
Author(s): 
Voza T, Kebaier C, Vanderberg JP
Reference: 
Malaria Journal 2010, 9:362 (15 December 2010)

The use of a sub-microlitre syringe for intradermal injections yielded excellent protective immunity.

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A retrospective evaluation of the role of T cells in the development of malaria vaccine

September 10, 2010 - 13:13 -- Kabogo Ndegwa
Author(s): 
Moriya Tsuji
Reference: 
Experimental Parasitology, Volume 126, Issue 3, November 2010, Pages 421-425

Due to the fact that the life cycle of malaria parasites is complex, undergoing both an extracellular and intracellular phases in its host, the human immune system has to mobilize both the humoral and cellular arms of immune responses to fight against this parasitic infection.

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An early commitment to expression of a particular TCRVβ chain on CD8+ T cells responding to attenuated Plasmodium berghei sporozoites is maintained following challenge with infectious sporozoites

August 30, 2010 - 06:17 -- Kabogo Ndegwa
Author(s): 
J. M. Lumsden, M. A. Cranmer, U. Krzych
Reference: 
Parasite Immunology, Volume 32, Issue 9-10, pages 644–655, September/October 2010

Protection induced by irradiated Plasmodium berghei sporozoites (Pbγ-spz) in mice is linked to CD8+ T cells specific for exo-erythrocytic-stage Ags, and intrahepatic memory CD8+ T cells are associated with protracted protection.

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Open Access | Immunization with Pre-Erythrocytic Antigen CelTOS from Plasmodium falciparum Elicits Cross-Species Protection against Heterologous Challenge with Plasmodium berghei

August 26, 2010 - 14:40 -- Kabogo Ndegwa
Author(s): 
Elke S Bergmann-Leitner, Ryan M. Mease, Patricia De La Vega, Tatyana Savranskaya, Mark Polhemus, Christian Ockenhouse, Evelina Angov
Reference: 
PLoS ONE 5(8): e12294

Immunization with PfCelTOS resulted in potent humoral and cellular immune responses and most importantly induced sterile protection against a heterologous challenge with P. berghei sporozoites in a proportion of both inbred and outbred mice.

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Open Access | Extreme CD8 T Cell Requirements for Anti-Malarial Liver-Stage Immunity following Immunization with Radiation Attenuated Sporozoites

August 2, 2010 - 13:26 -- Patrick Sampao
Author(s): 
Nathan W. Schmidt, Noah S. Butler, Vladimir P. Badovinac, John T. Harty
Reference: 
PLoS Pathog 6(7): e1000998

Here, we used surrogate T cell activation markers to identify and track whole-parasite, RAS-vaccine-induced effector and memory CD8 T cell responses. Our data show that the differential susceptibility of RAS-immune inbred mouse strains to Plasmodium berghei or P. yoelii sporozoite challenge does not result from host- or parasite-specific decreases in the CD8 T cell response.

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Malaria vaccine efficacy: overcoming the helminth hurdle

July 19, 2010 - 13:26 -- Kabogo Ndegwa
Author(s): 
JV Cruz-Chan, M Rosado-Vallado, E Dumonteil
Reference: 
Expert Review of Vaccines, July 2010, Vol. 9, No. 7, Pages 707-711

Several studies have documented that helminth infections can interfere with the development of the immune response of vaccines against different diseases, although some results have been contradictory.

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