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infection

The distribution of Plasmodium falciparum infection durations

December 7, 2011 - 14:39 -- Patrick Sampao
Author(s): 
Michael T. Bretscher, Nicolas Maire, Nakul Chitnis, Ingrid Felger, Seth Owusu-Agyei, Tom Smith
Reference: 
Epidemics, Volume 3, Issue 2, June 2011, Pages 109-118

MalariaWorldWe conclude that malariatherapy data, the most important source of information on P. falciparum within-host dynamics, may not be representative of the actual processes in natural populations, and should be used with care.

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Open Access | Adaptation of a visualized loop-mediated isothermal amplification technique for field detection of Plasmodium vivax infection

June 22, 2011 - 14:53 -- Patrick Sampao
Author(s): 
Zhi-Yong Tao, Hua-Yun Zhou, Qi Gao, et al.
Reference: 
Parasites & Vectors 2011, 4:115, 21 June 2011

In this study, we establish a novel visualized LAMP method in a closed-tube system, and validate it for the diagnosis of malaria under simulated field conditions.

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Parasitology: Validation of PCR for detection and characterization of parasitaemia in massive splenomegaly attributed clinically to malaria infection

May 17, 2011 - 15:19 -- Patrick Sampao
Author(s): 
Salwa M.E. A-Elgayoum, El-Amin El-Rayah, Hayder A. Giha
Reference: 
Diagnostic Microbiology and Infectious Disease, Volume 70, Issue 2, June 2011, Pages 207-212

In this study, 101 patients with massive splenomegaly (MS) and 41 with moderate splenomegaly (MoS) from Kassala, Eastern Sudan, were included.

Open Access | Fatal Myocarditis in Course of Plasmodium falciparum Infection: Case Report and Review of Cardiac Complications in Malaria

May 9, 2011 - 14:19 -- Patrick Sampao
Author(s): 
Paola Costenaro, Paolo Benedetti,Chiara Facchin, Carlo Mengoli, and Giampietro Pellizzer
Reference: 
Case Report Med. 2011; 2011: 202083.

This case recalls the potential importance of myocardial injury in the prognosis of malaria and prompts a reevaluation of current perspectives on the pathogenesis of severe falciparum infection.

Review: A plethora of Plasmodium species in wild apes: a source of human infection?

April 29, 2011 - 10:43 -- Patrick Sampao
Author(s): 
Julian C. Rayner, Weimin Liu, Martine Peeters, Paul M. Sharp, Beatrice H. Hahn
Reference: 
Trends in Parasitology, Volume 27, Issue 5, May 2011, Pages 222-229

These findings raise the question whether wild apes could be a recurrent source of Plasmodium infections in humans. This question is not new, but was the subject of intense investigation by researchers in the first half of the last century.

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Iron Homeostasis in Mother and Child during Placental Malaria Infection

January 7, 2011 - 11:47 -- Patrick Sampao
Author(s): 
Susanne Van Santen, Quirijn de Mast, Adrian J. F. Luty, Erwin T. Wiegerinck, Andre J. A. M. Van der Ven, AND Dorine W. Swinkels
Reference: 
Am J Trop Med Hyg, Jan 2011; 84: 148 - 151.

We conclude that maternal hepcidin is not significantly altered as a function of placental infection and/or anemia. Importantly, fetal hemoglobin and iron status were also unaffected, regardless of the presence of placental infection or maternal anemia.

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Brief Report: Abdominal Computed Tomography Findings of Malaria Infection with Plasmodium vivax

December 2, 2010 - 12:48 -- Patrick Sampao
Author(s): 
Eun Mi Kim, Hyeon Je Cho, Chong Rae Cho, Yee Gyung Kwak, Mi Young Kim, AND Yun Ku Cho
Reference: 
Am J Trop Med Hyg, Dec 2010; 83: 1202 - 1205.

To identify abdominal CT findings, we selected 34 of 405 patients who had a positive peripheral blood smear for Plasmodium vivax and had underwent abdominal CT as the malaria group.

Memory-like IFN- response by NK cells following malaria infection reveals the crucial role of T cells in NK cell activation by P. falciparum

November 26, 2010 - 13:21 -- Patrick Sampao
Author(s): 
Matthew B. B. McCall., Meta Roestenberg., Robert W. Sauerwein., et al.
Reference: 
European Journal of Immunology, Volume 40, Issue 12, pages 3472–3477, December 2010

Here, we studied the dynamics of and requirements for in vitro NK responses to PfRBC in malaria-naïve volunteers undergoing a single experimental malaria infection under highly controlled circumstances, and in naturally exposed individuals. NK-specific IFN-γ responses to PfRBC following exposure resembled an immunological recall pattern and were tightly correlated with T-cell responses.

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Testosterone-induced permanent changes of hepatic gene expression in female mice sustained during Plasmodium chabaudi malaria infection

November 24, 2010 - 09:11 -- Patrick Sampao
Author(s): 
Denis Delic, Nicole Gailus, Hans-Werner Vohr, Mohamed Dkhil, Saleh Al-Quraishy and Frank Wunderlich
Reference: 
Journal of Molecular Endocrinology (2010) 45 379-390 

Here, we investigate as to whether this conversion coincides with permanent changes of hepatic gene expression profiles. Female mice aged 10–12 weeks were treated with testosterone for 3 weeks; then, testosterone treatment was discontinued for 12 weeks before challenging with 106 P. chabaudi-infected erythrocytes.

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Open Access | Oral Presentation: Molecular epidemiology of force of infection in malaria

November 8, 2010 - 08:56 -- Patrick Sampao
Author(s): 
Ingrid Felger, Sonja Schoepflin, Benson Kiniboro, Peter A Zimmerman, Ivo Mueller
Reference: 
Malaria Journal 2010, 9(Suppl 2):O14 (20 October 2010)

We investigated the ability of molecular parameters to explain differences in the risk of P. falciparum infection and disease between wet and dry seasons, among age groups and with respect to insecticide-treated mosquito net use.

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