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endoperoxide carbon

Rationale Design of Biotinylated Antimalarial Endoperoxide Carbon Centered Radical Prodrugs for Applications in Proteomics

May 25, 2010 - 09:12 -- Kabogo Ndegwa
V Barton, SA Ward, J Chadwick, A Hill, PM O'Neill
J. Med. Chem, May 18, 2010

The semisynthetic artemisinin derivatives such as artesunate and artemether, along with the fully synthetic endoperoxide antimalarials (e.g., OZ277, Nature 2004, 430, 900−904), are believed to mediate their antimalarial effects by iron-induced formation of carbon-centered radicals capable of alkylating heme and/or protein.

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