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Open Access | Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite

June 29, 2010 - 09:43 -- Kabogo Ndegwa
Kerstin Leykauf, Moritz Treeck, Paul R. Gilson, Thomas Nebl, Thomas Braulke, Alan F. Cowman, Tim W. Gilberger, Brendan S. Crabb
PLoS Pathog 6(6): e1000941

Apicomplexan parasites are obligate intracellular parasites that infect a variety of hosts, causing significant diseases in livestock and humans. The invasive forms of the parasites invade their host cells by gliding motility, an active process driven by parasite adhesion proteins and molecular motors.

Open Access | A Plasmodium falciparum Transcriptional Cyclin-Dependent Kinase-Related Kinase with a Crucial Role in Parasite Proliferation Associates with Histone Deacetylase Activity

June 4, 2010 - 08:08 -- Patrick Sampao
Jean H., Lawrence A., et al.
Eukaryotic Cell, June 2010, p. 952-959, Vol. 9, No. 6

We show that recombinant Pfcrk-3 associates with histone H1 kinase activity in parasite extracts and that this association is detectable even if the catalytic domain of Pfcrk-3 is rendered inactive by site-directed mutagenesis, indicating that Pfcrk-3 is part of a complex that includes other protein kinases.

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Short Communication: Complementation of Saccharomyces cerevisiae pik1ts by a phosphatidylinositol 4-kinase from Plasmodium falciparum

May 21, 2010 - 08:18 -- Patrick Sampao
Tim Krüger, Cecilia P. Sanchez, Michael Lanzer
Molecular and Biochemical Parasitology, Volume 172, Issue 2, August 2010, Pages 149-151

Our data show that the corresponding P. falciparum gene, termed PFE0485w, can functionally complement a yeast temperature-sensitive pik1 mutation.

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