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Tafenoquine, an Antiplasmodial 8-Aminoquinoline, Targets Leishmania Respiratory Complex III and Induces Apoptosis

November 19, 2010 - 11:33 -- Kabogo Ndegwa
Luis Carvalho, Juan Román Luque-Ortega, José Ignacio Manzano, Santiago Castanys, Luis Rivas, and Francisco Gamarro
Antimicrobial Agents and Chemotherapy, December 2010, p. 5344-5351, Vol. 54, No. 12

Tafenoquine (TFQ), an 8-aminoquinoline analogue of primaquine, which is currently under clinical trial (phase IIb/III) for the treatment and prevention of malaria, may represent an alternative treatment for leishmaniasis.

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Open Access | Partial mitochondrial DNA sequences suggest the existence of a cryptic species within the Leucosphyrus group of the genus Anopheles (Diptera: Culicidae), forest malaria vectors, in northern Vietnam

May 4, 2010 - 11:54 -- Patrick Sampao
Kohei T T., Ngoc Thi H N., et al.
Parasites & Vectors 2010, 3:41

The results suggest the existence of a cryptic species in northern Vietnam that is morphologically similar to, but phylogenetically distant from both An. dirus and An. takasagoensis.


Open Access | Comparative detection of Plasmodium vivax and Plasmodium falciparum DNA in saliva and urine samples from symptomatic malaria patients in a low endemic area

March 14, 2010 - 10:17 -- Ingeborg van Schayk
Pattakorn Buppan, Chaturong Putaporntip, Urassaya Pattanawong, Sunee Seethamchai, Somchai Jongwutiwes
Malaria Journal 2010, 9:72 (9 March 2010)

Saliva and urine samples could be alternative noninvasive sources of DNA for molecular detection of both P. falciparum and P. vivax. Further improvement of the detection method will offer an opportunity to use these samples for diagnosis of malaria.

A Unique 45-Amino-Acid Region in the Toprim Domain of Plasmodium falciparum Gyrase B Is Essential for Its Activity

November 11, 2009 - 09:03 -- Ingeborg van Schayk
Ashraf Dar, Dhaneswar Prusty, Neelima Mondal, and Suman K. Dhar
Eukaryotic Cell 2009;8 1759-1769

This study is an attempt to understand whether the B subunit of DNA gyrase binds to DNA directly, which may be central to the stimulation of its ATPase activity essential for gyrase function. 


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