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artemisinin susceptibility

Open Access | Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum

May 17, 2010 - 09:12 -- Kabogo Ndegwa
Author(s): 
Stephanie G. Valderramos, Juan-Carlos Valderramos, Lise Musset, Lisa A. Purcell, Odile Mercereau-Puijalon, Eric Legrand, David A. Fidock
Reference: 
PLoS Pathog 6(5): e1000887.

Mutant forms of the Plasmodium falciparum transporter PfCRT constitute the key determinant of parasite resistance to chloroquine (CQ), the former first-line antimalarial, and are ubiquitous to infections that fail CQ treatment.

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