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T Cell

Open Access | Low doses of killed parasite in CpG elicit vigorous CD4+ T cell responses against blood-stage malaria in mice

July 19, 2010 - 12:16 -- Kabogo Ndegwa
A Pinzon-Charry, V McPhun, V Kienzle, C Hirunpetcharat, C Engwerda, J McCarthy, MF Good
J Clin Invest, July 12, 2010

Development of a vaccine that targets blood-stage malaria parasites is imperative if we are to sustainably reduce the morbidity and mortality caused by this infection.

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Cellular Immunology and Immune Regulation: Cross-Talk between T Cells and NK Cells Generates Rapid Effector Responses to Plasmodium falciparum-Infected Erythrocytes

May 31, 2010 - 12:22 -- Kabogo Ndegwa
Amir Horowitz, Kirsty C. Newman, J. Henry Evans, Daniel S. Korbel, Daniel M. Davis, and Eleanor M. Riley
J. Immunol., Jun 2010; 184: 6043 – 6052

Rapid cell-mediated immune responses, characterized by production of proinflammatory cytokines, such as IFN-{gamma}, can inhibit intraerythrocytic replication of malaria parasites and thereby prevent onset of clinical malaria.

Open Access | Prolonged Antigen Presentation Is Required for Optimal CD8+ T Cell Responses against Malaria Liver Stage Parasites

May 10, 2010 - 08:52 -- Kabogo Ndegwa
Ian A. Cockburn, Yun-Chi Chen, Michael G. Overstreet, Jason R. Lees, Nico van Rooijen, Donna L. Farber, Fidel Zavala
PLoS Pathog 6(5): e1000877

Immunization with irradiated sporozoites is currently the most effective vaccination strategy against liver stages of malaria parasites, yet the mechanisms underpinning the success of this approach are unknown. Here we show that the complete development of protective CD8+ T cell responses requires prolonged antigen presentation.

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