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immune response

Review: Suppression of vaccine responses by malaria: insignificant or overlooked?

April 13, 2010 - 14:14 -- Kabogo Ndegwa
Author(s): 
Aubrey J Cunnington, Eleanor M Riley
Reference: 
Expert Rev Vaccines April 2010, Vol. 9, No. 4, Pages 409-429

Malaria is widely reported to suppress immune responses to heterologous antigens, including vaccines, but the evidence base for this assumption is patchy and confusing.

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Cellular Immunology and Immune Regulation: Protein–DNA Complex Is the Exclusive Malaria Parasite Component That Activates Dendritic Cells and Triggers Innate Immune Responses

April 8, 2010 - 13:14 -- Kabogo Ndegwa
Author(s): 
Xianzhu Wu, Nagaraj M. Gowda, Sanjeev Kumar, and D. Channe Gowda
Reference: 
The Journal of Immunology, 2010, Volume 184, Issue 8 Pages 4338 -4348

Dendritic cells (DCs) play a crucial role in the development of protective immunity to malaria. However, it remains unclear how malaria parasites trigger immune responses in DCs.

Acquired immune response to defined Plasmodium vivax antigens in individuals residing in northern India

February 25, 2010 - 21:59 -- Kabogo Ndegwa
Author(s): 
Ratanesh K. Seth, Ajaz A. Bhat, Donthamsetty N. Rao, Sukla Biswas
Reference: 
Microbes and Infection, Volume 12, Issue 3, March 2010, Pages 199-206

In this investigation, we evaluated the naturally acquired immune response to Plasmodium vivax stage-specific antigens in individuals of different age groups belonging to malaria endemic areas of northern India.

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Opinion: Regulatory T cells in malaria – friend or foe?

February 4, 2010 - 15:34 -- Kabogo Ndegwa
Author(s): 
Olivia C. Finney, Eleanor M. Riley and Michael Walther
Reference: 
Trends in Immunology, Volume 31, Issue 2, February 2010, Pages 63-70

Here, we review these studies, focussing in particular on recent studies in humans, propose a model by which different regulatory T cell populations might contribute to the control of inflammation at different stages of infection and discuss the implications for the design of safe and effective malaria vaccines.

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Open Access | Naturally-acquired humoral immune responses against the N- and C-termini of the Plasmodium vivax MSP1 protein in endemic regions of Brazil and Papua New Guinea using a multiplex assay

January 29, 2010 - 14:27 -- Ingeborg van Schayk
Author(s): 
Carmen Fernandez-Becerra, Sergi Sanz, Marina Brucet, Danielle I Stanisic, Fabiana P Alves, Erney P Camargo, Pedro L Alonso, Ivo Mueller, Hernando A del Portillo
Reference: 
Malaria Journal 2010, 9:29 (21 January 2010)

This study validates the use of the multiplex assay to measure naturally-acquired IgG antibodies against the merozoite surface protein 1 of P. vivax.

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Multiple functions of human T cells generated by experimental malaria challenge

November 10, 2009 - 20:40 -- Ingeborg van Schayk
Author(s): 
Stephen M. Todryk, Michael Walther, Philip Bejon, Claire Hutchings, Fiona M. Thompson, Britta C. Urban, David W. Porter, Adrian V. S. Hill
Reference: 
European Journal of Immunology, Volume 39 Issue 11, Pages 3042 – 3051

In this study, cellular immune responses were investigated in individuals receiving Plasmodium falciparum sporozoite challenge by the natural (mosquito bite) route as part of a malaria vaccine efficacy trial. 

 

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