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DNA replication

The malarial CDK Pfmrk and its effector PfMAT1 phosphorylate DNA replication proteins and co-localize in the nucleus

May 3, 2010 - 15:27 -- Patrick Sampao
Author(s): 
Dayadevi Jirage, Yueqin Chen, Diana Caridha, Michael T. O’Neil, Fredrick Eyase, William H. Witola, Choukri Ben Mamoun, Norman C. Waters
Reference: 
Molecular and Biochemical Parasitology, Volume 172, Issue 1, July 2010, Pages 9-18

We demonstrate that that these two proteins are substrates of Pfmrk-mediated phosphorylation and that PfMAT1 confers substrate specificity to the Pfmrk kinase complex.

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