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CDK Pfmrk

The malarial CDK Pfmrk and its effector PfMAT1 phosphorylate DNA replication proteins and co-localize in the nucleus

May 3, 2010 - 15:27 -- Patrick Sampao
Dayadevi Jirage, Yueqin Chen, Diana Caridha, Michael T. O’Neil, Fredrick Eyase, William H. Witola, Choukri Ben Mamoun, Norman C. Waters
Molecular and Biochemical Parasitology, Volume 172, Issue 1, July 2010, Pages 9-18

We demonstrate that that these two proteins are substrates of Pfmrk-mediated phosphorylation and that PfMAT1 confers substrate specificity to the Pfmrk kinase complex.

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