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p.falciparum

Structural and Functional Insights into the Malaria Parasite Moving Junction Complex

June 26, 2012 - 10:02 -- Kabogo Ndegwa
Author(s): 
Brigitte Vulliez-Le Normand, Michelle L. Tonkin, Mauld H. Lamarque, Susann Langer, Sylviane Hoos, Magali Roques, Frederick A. Saul, Bart W. Faber, Graham A. Bentley, Martin J. Boulanger, Maryse Lebrun
Reference: 
PLoS Pathog 8(6): e1002755

MalariaWorldMembers of the phylum Apicomplexa, which include the malaria parasite Plasmodium, share many features in their invasion mechanism in spite of their diverse host cell specificities and life cycle characteristics.

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Quantitative detection of PfHRP2 in saliva of malaria patients in the Philippines

May 29, 2012 - 12:02 -- Kabogo Ndegwa
Author(s): 
Fung AO, Damoiseaux R, Grundeen S, Panes JL, Horton DH, Judy JW, Moore TB
Reference: 
Malaria Journal 2012, 11:175 (25 May 2012)

MalariaWorldSaliva is a promising diagnostic fluid for malaria when protein degradation and matrix effects are mitigated.

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Open Access | Malaria control in Bhutan: a case study of a country embarking on elimination

January 11, 2012 - 08:47 -- Kabogo Ndegwa
Author(s): 
Yangzom T, Smith Gueye C, Namgay R, Galappaththy GN, Thimasarn K, Gosling R, Murugasampillay S, Dev V
Reference: 
Malaria Journal 2012, 11:9 (9 January 2012)

MalariaWorldBhutan has made significant strides towards elimination and has adopted a goal of national elimination.

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Cyclopropyl Carboxamides, a Chemically Novel Class of Antimalarial Agents Identified in a Phenotypic Screen

November 15, 2011 - 07:25 -- Kabogo Ndegwa
Author(s): 
Laura M. Sanz, M. Belen Jiménez-Díaz, Francisco-Javier Gamo, et al.
Reference: 
Antimicrob. Agents Chemother. December 2011 vol. 55 no. 12 5740-5745

MalariaWorldMalaria is one of the deadliest infectious diseases in the world, with the eukaryotic parasite Plasmodium falciparum causing the most severe form of the disease.

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Open Access | Sexual recombination is a signature of a persisting malaria epidemic in Peru

November 2, 2011 - 09:20 -- Kabogo Ndegwa
Author(s): 
Sutton PL, Torres LP, Branch OH
Reference: 
Malaria Journal 2011, 10:329 (31 October 2011)

MalariaWorldContrary to conventional low transmission models, this study provides evidence of a parasite population structure that is superficially defined by a clonal backbone.

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Open Access | Drug-Resistant Genotypes and Multi-Clonality in Plasmodium falciparum Analysed by Direct Genome Sequencing from Peripheral Blood of Malaria Patients

August 24, 2011 - 09:12 -- Kabogo Ndegwa
Author(s): 
Timothy Robinson, Susana G. Campino, Sarah Auburn, Samuel A. Assefa, Spencer D. Polley, Magnus Manske, Bronwyn MacInnis, Kirk A. Rockett, Gareth L. Maslen, Mandy Sanders, Michael A. Quail, Peter L. Chiodini, Dominic P. Kwiatkowski, Taane G. Clark, Colin J. Sutherland
Reference: 
PLoS ONE 6(8): e23204

Naturally acquired blood-stage infections of the malaria parasite Plasmodium falciparum typically harbour multiple haploid clones.

Open Access | Evidence for erythrocyte-binding antigen 175 as a component of a ligand-blocking blood-stage malaria vaccine

May 5, 2011 - 06:29 -- Kabogo Ndegwa
Author(s): 
Lubin Jiang, Deepak Gaur, Jianbing Mu, Hong Zhou, Carole A. Long, and Louis H. Miller
Reference: 
PNAS May 3, 2011 vol. 108 no. 18 7553-7558

The ligands that pathogens use to invade their target cells have often proven to be good targets for vaccine development.

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Open Access | Targeted Disruption of py235ebp-1: Invasion of Erythrocytes by Plasmodium yoelii Using an Alternative Py235 Erythrocyte Binding Protein

February 23, 2011 - 09:29 -- Kabogo Ndegwa
Author(s): 
Solabomi A. Ogun, Rita Tewari, Thomas D. Otto, Steven A. Howell, Ellen Knuepfer, Deirdre A. Cunningham, Zhengyao Xu, Arnab Pain, Anthony A. Holder
Reference: 
PLoS Pathog 7(2): e1001288

Plasmodium yoelii YM asexual blood stage parasites express multiple members of the py235 gene family, part of the super-family of genes including those coding for Plasmodium vivax reticulocyte binding proteins and Plasmodium falciparum RH proteins.

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Open Access | Evaluation of prevalences of pfdhfr and pfdhps mutations in Angola

February 9, 2011 - 07:46 -- Kabogo Ndegwa
Author(s): 
Fortes F, Dimbu R, Figueiredo P, Neto Z, do Rosario VE, Lopes D
Reference: 
Malaria Journal 2011, 10:22 (2 February 2011)

The data showed that the implementation IPT using SP in children needs to be reviewed.

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Randomized double-blind controlled Phase I/IIa trial to assess the efficacy of malaria vaccine PfCS102 to protect against challenge with P. falciparum

September 14, 2010 - 12:34 -- Patrick Sampao
Author(s): 
Blaise G., Valérie D., et al.
Reference: 
Vaccine, Volume 28, Issue 40, 14 September 2010, Pages 6573-6580

The aim of this Phase I/IIa double-blind controlled trial was to test the efficacy of the sporozoite-based malaria vaccine PfCS 282–383 (PfCS102) to protect against Plasmodium falciparum parasitaemia.

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