Members of the phylum Apicomplexa, which include the malaria parasite Plasmodium, share many features in their invasion mechanism in spite of their diverse host cell specificities and life cycle characteristics.
Saliva is a promising diagnostic fluid for malaria when protein degradation and matrix effects are mitigated.
Bhutan has made significant strides towards elimination and has adopted a goal of national elimination.
Malaria is one of the deadliest infectious diseases in the world, with the eukaryotic parasite Plasmodium falciparum causing the most severe form of the disease.
Contrary to conventional low transmission models, this study provides evidence of a parasite population structure that is superficially defined by a clonal backbone.
Naturally acquired blood-stage infections of the malaria parasite Plasmodium falciparum typically harbour multiple haploid clones.
The ligands that pathogens use to invade their target cells have often proven to be good targets for vaccine development.
Plasmodium yoelii YM asexual blood stage parasites express multiple members of the py235 gene family, part of the super-family of genes including those coding for Plasmodium vivax reticulocyte binding proteins and Plasmodium falciparum RH proteins.
The data showed that the implementation IPT using SP in children needs to be reviewed.
The aim of this Phase I/IIa double-blind controlled trial was to test the efficacy of the sporozoite-based malaria vaccine PfCS 282–383 (PfCS102) to protect against Plasmodium falciparum parasitaemia.