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genetic

Multilocus nuclear DNA markers and genetic parameters in an Indian Anopheles minimus population

March 31, 2011 - 12:28 -- Patrick Sampao
Author(s): 
Jyotsana Dixit, Hemlata Srivastava, O.P. Singh, D.N. Saksena, Aparup Das
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 3, April 2011, Pages 572-579

Considering malaria is a highly fatal vector-borne infectious disease, inference on population genetic structure and demography could be of help in the long run for malaria vector management and control. Using the published genome sequence information of Anopheles gambiae we designed EPIC primers

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The Kennedy phospholipid biosynthesis pathways are refractory to genetic disruption in Plasmodium berghei and therefore appear essential in blood stages

July 19, 2010 - 09:40 -- Patrick Sampao
Author(s): 
Sandrine Déchamps, Kai Wengelnik, Laurence Berry-Sterkers, Rachel Cerdan, Henri J. Vial, Laila Gannoun-Zaki
Reference: 
Molecular and Biochemical Parasitology, Volume 173, Issue 2, October 2010, Pages 69-80

Here, we have studied the essential nature of the Kennedy pathways in Plasmodium berghei, a rodent malaria parasite. Sequence analysis of the P. berghei CEPT, CCT, ECT and CK enzymes revealed the presence of all catalytic domains and essential residues and motifs necessary for enzymatic activities.

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Microgeographic Genetic Variation of the Malaria Vector Anopheles darlingi Root (Diptera: Culicidae) from Córdoba and Antioquia, Colombia

July 2, 2010 - 13:16 -- Patrick Sampao
Author(s): 
Lina A. Gutiérrez, Giovan F. Gómez, John J. González, Martha I. Castro, Shirley Luckhart, Jan E. Conn, AND Margarita M. Correa
Reference: 
Am J Trop Med Hyg, Jul 2010; 83: 38 - 47.

This study was conducted to test genetic variation of An. darlingi at a microgeographic scale (approximately 100 km) from localities in Córdoba and Antioquia states, in western Colombia, to better understand the potential contribution of population genetics to local malaria control programs.

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Open Access | Population genetic structure of the malaria vector Anopheles nili in sub-Saharan Africa

June 15, 2010 - 06:56 -- Kabogo Ndegwa
Author(s): 
Ndo C, Antonio-Nkondjio C, Cohuet A, Ayala D, Kengne P, Morlais I, Awono-Ambene PH, Couret D, Ngassam P, Fontenille D, Simard F
Reference: 
Malaria Journal 2010, 9:161 (12 June 2010)

Overall, high genetic homogeneity of the An. nili gene pool was found across its distribution range in West and Central Africa, although demographic events probably resulted in a higher level of genetic isolation in the marginal population of Kenge (DRC).

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Genetic association of Toll-like-receptor 4 and tumor necrosis factor-α polymorphisms with Plasmodium falciparum blood infection levels

May 27, 2010 - 15:05 -- Patrick Sampao
Author(s): 
Madhumita B., Ardhendu K. M., et al.
Reference: 
Infection, Genetics and Evolution, Volume 10, Issue 5, July 2010, Pages 686-696

Association of parasite load with genotypes was examined using model based and model free approaches.

Short Communication: Genetic changes during laboratory propagation: Copy number At the reticulocyte-binding protein 1 locus of Plasmodium falciparum

May 21, 2010 - 07:30 -- Patrick Sampao
Author(s): 
Shalini Nair, Standwell Nkhoma, François Nosten, Mayfong Mayxay, Neil French, Jim Whitworth, Tim Anderson
Reference: 
Molecular and Biochemical Parasitology, Volume 172, Issue 2, August 2010, Pages 145-148

These data show that CNV at PfRh1 is rare or non-existent in natural populations, but can arise during laboratory propagation. We conclude that PfRh1 CNV is not an important determinant of gene expression, cell invasion or growth rate in natural parasite populations.

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