Artemether and lumefantrine (also known as benflumetol) are difficult to formulate for parenteral administration because of their low aqueous solubility.
Antimicrob. Agents Chemother. October 2014 vol. 58 no. 10 5658-5665
Malaria Journal 2010, 9:205 (14 July 2010)
Experience gained in this setting could help to improve spontaneous reporting of AEs and SAEs to health authorities or marketing authorization holders.