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Open Access | Invited Speaker Presentation: Structure function analysis of P. falciparum VAR2CSA

November 3, 2010 - 12:45 -- Patrick Sampao
Madeleine Dahlbäck, Lars M Jørgensen, Stig Christoffersen, Morten A Nielsen, Thor G Theander, David E Arnot, Sine Larsen, Ali Salanti
Malaria Journal 2010, 9(Suppl 2):I4 (20 October 2010)

Understanding the mechanism behind this specific CSA interaction is important for the optimal design of a vaccine against placental malaria.

Medical Condition: 

Open Access | The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs

April 20, 2010 - 09:29 -- Kabogo Ndegwa
Joergensen LM, Salanti A, Dobrilovic T, Barfod L, Hassenkam T, Theander TG, Hviid L, Arnot DE
Malaria Journal 2010, 9:100 (19 April 2010)

High avidity is required to achieve the strongest binding to VAR2CSA PfEMP1, but the structures that display PfEMP1 also tend to inhibit cross-linking between PfEMP1 antigens, by holding many binding epitopes at distances beyond the 15-18nm sweep radius of an antibody.

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