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P. berghei

Trypanosoma brucei infection protects mice against malaria

November 12, 2019 - 16:10 -- Open Access
Sanches-Vaz M, Temporão A, Luis R, Nunes-Cabaço H, Mendes AM, Goellner S, Carvalho T, Figueiredo LM, Prudêncio M.
PLoS Pathog. 2019 Nov 8;15(11):e1008145

Sleeping sickness and malaria are parasitic diseases with overlapping geographical distributions in sub-Saharan Africa. We hypothesized that the immune response elicited by an infection with Trypanosoma brucei, the etiological agent of sleeping sickness, would inhibit a subsequent infection by Plasmodium, the malaria parasite, decreasing the severity of its associated pathology.

Medical Condition: 

Neuroimmunological Blood Brain Barrier Opening in Experimental Cerebral Malaria

November 12, 2012 - 08:20 -- Open Access
Adela Nacer, Alexandru Movila, Kerstin Baer, Sebastian A. Mikolajczak, Stefan H. I. Kappe, Ute Frevert
PLoS Pathog 8(10): e1002982

Plasmodium falciparum malaria is responsible for nearly one million annual deaths worldwide.

Medical Condition: 

Arrest of Nuclear Division in Plasmodium through Blockage of Erythrocyte Surface Exposed Ribosomal Protein P2

August 15, 2012 - 07:33 -- Kabogo Ndegwa
Sudipta Das, Himanish Basu, Reshma Korde, Rita Tewari, Shobhona Sharma
PLoS Pathogens 8(8): e1002858

MalariaWorldMalaria parasites reside inside erythrocytes and the disease manifestations are linked to the growth inside infected erythrocytes (IE).

Improved methods for haemozoin quantification in tissues yield organ- and parasite-specific information in malaria infected mice

May 16, 2012 - 07:01 -- Kabogo Ndegwa
Deroost K, Lays N, Noppen S, Martens E, Opdenakker G, Van den Steen PE
Malaria Journal 2012, 11:166 (14 May 2012)

MalariaWorldThe developed techniques were useful to quantify Hz in different organs with a high reproducibility and sensitivity.

Open Access | In vitro and in vivo anti-malarial activity of Boerhavia elegans and Solanum surattense

May 13, 2010 - 14:27 -- Kabogo Ndegwa
Ramazani A, Zakeri S, Sardari S, Khodakarim N, Djadid N
Malaria Journal 2010, 9:124 (12 May 2010)

Anti-plasmodial activities of extracts of B. elegans and S. surattense are reported for the first time.

Medical Treatment: 

Open Access | Beneficial effect of aurothiomalate on murine malaria

May 10, 2010 - 08:56 -- Kabogo Ndegwa
Alesutan I, Bobbala D, Qadri SM, Estremera A, Foller M, Lang F
Malaria Journal 2010, 9:118 (7 May 2010)

Sodium aurothiomalate influences the survival of Plasmodium berghei-infected mice, an effect only partially explained by stimulation of eryptosis.

Open Access | Alpha-tocopherol transfer protein disruption confers resistance to malarial infection in mice

April 20, 2010 - 09:25 -- Kabogo Ndegwa
Herbas MS, Ueta YY, Ichikawa C, Chiba M, Ishibashi K, Shichiri M, Fukumoto S, Yokoyama N, Takeya M, Xuan X, Arai H, Suzuki H
Malaria Journal 2010, 9:101 (19 April 2010)

Various factors impact the severity of malaria, including the nutritional status of the host. Vitamin E, an intra and extracellular anti-oxidant, is one such nutrient whose absence was shown previously to negatively affect Plasmodium development.

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