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Plasmodium falciparum

Case Report: Artesunate for Severe Acute Plasmodium falciparum Infection in a Patient with Myasthenia Gravis

September 7, 2012 - 04:34 -- Patrick Sampao
Author(s): 
Nathalie Dournon, Pierre Buffet, Eric Caumes, Bernard Clair and Stéphane Jauréguiberry
Reference: 
Am J Trop Med Hyg 2012 87:435-436

MalariaWorldWe report a case of severe malaria in a patient with underlying myasthenia gravis who was successfully treated with artesunate.

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Analysis of the trap gene provides evidence for the role of elevation and vector abundance in the genetic diversity of Plasmodium relictum in Hawaii

September 5, 2012 - 06:55 -- Kabogo Ndegwa
Author(s): 
Farias ME, Atkinson CT, LaPointe DA, Jarvi SI
Reference: 
Malaria Journal 2012, 11:305 (3 September 2012)

MalariaWorldThe results of this study suggest that pathogen diversity in Hawaii may be driven by a complex interaction of factors including transmission rates, host immune pressures, and parasite-parasite competition.

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Eurartesim®: a guide to its use in the treatment of uncomplicated Plasmodium falciparum malaria

September 4, 2012 - 14:56 -- Patrick Sampao
Author(s): 
Keating, Gillian M
Reference: 
Drugs & Therapy Perspectives, Volume 28, Number 10, 1 October 2012 , pp. 1-5(5)

MalariaWorldThe Eurartesim® formulation of dihydroartemisinin/piperaquine is the only formulation to meet international good manufacturing practice standards.

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Not Open Access | A single amino acid change in the Plasmodium falciparum RH5 (PfRH5) human RBC binding sequence modifies its structure and determines species-specific binding activity

September 3, 2012 - 14:05 -- Patrick Sampao
Author(s): 
Gabriela Arévalo-Pinzón, Hernando Curtidor, Marina Muñoz, Manuel A. Patarroyo, Adriana Bermudez, Manuel E. Patarroyo
Reference: 
Vaccine, Volume 30, Issue 3, 11 January 2012, Pages 637-646

MalariaWorldOur results show that a single amino acid change in the HABP 36727 sequence modifies a peptide's 3D structure, thereby resulting in a loss of specific binding to human RBCs and its inhibition ability, while binding to Aotus RBC remains unmodified.

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Not Open Access | The effect of adjuvants on the immune response induced by a DBL4ɛ-ID4 VAR2CSA based Plasmodium falciparum vaccine against placental malaria

September 3, 2012 - 13:46 -- Patrick Sampao
Author(s): 
V.V. Pinto, A. Salanti, L.M. Joergensen, M. Dahlbäck, M. Resende, S.B. Ditlev, E.M. Agger, D.E. Arnot, T.G. Theander, M.A. Nielsen
Reference: 
Vaccine, Volume 30, Issue 3, 11 January 2012, Pages 572-579

MalariaWorldHere we tested the ability of DBL4ɛ-ID4 to induce binding-inhibitory antibodies when formulated with adjuvants approved for human use.

An Image-Based Drug Susceptibility Assay Targeting the Placental Sequestration of Plasmodium falciparum-Infected Erythrocytes

September 3, 2012 - 07:56 -- Kabogo Ndegwa
Author(s): 
Min-Je Ku, Fernando de M. Dossin, Michael A. E. Hansen, Auguste Genovesio, Lawrence Ayong, Lucio H. Freitas-Junior
Reference: 
PLoS ONE 7(8): e41765

MalariaWorldPlacental malaria is a significant cause of all malaria-related deaths globally for which no drugs have been developed to specifically disrupt its pathogenesis.

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NOT Open Access | Tandem synthesis and in vitro antiplasmodial evaluation of new naphtho[2,1-d]thiazole derivatives

September 3, 2012 - 07:53 -- Kabogo Ndegwa
Author(s): 
Anita Cohen, Pierre Verhaeghe, Maxime D. Crozet, Sébastien Hutter, Pascal Rathelot, Patrice Vanelle, Nadine Azas
Reference: 
European Journal of Medicinal Chemistry, Volume 55, September 2012, Pages 315–324

MalariaWorldA series of naphtho[2,1-d]thiazoles was prepared in good yields under microwave irradiation with an original protocol combining tandem direct arylation and intramolecular Knoevenagel reaction on 1,3-thiazole derivatives.

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NOT Open Access | One pot efficient diversity oriented synthesis of polyfunctional styryl thiazolopyrimidines and their bio-evaluation as antimalarial and anti-HIV agents

September 3, 2012 - 07:41 -- Kabogo Ndegwa
Author(s): 
Seerat Fatima, Anindra Sharma, Reshu Saxena, Rajkamal Tripathi, Sanjeev K. Shukla, Swaroop Kumar Pandey, Renu Tripathi, Rama P. Tripathi
Reference: 
European Journal of Medicinal Chemistry, Volume 55, September 2012, Pages 195–204

MalariaWorldAn efficient one pot synthesis of a series of pluripotent (E)-1-(3-methyl-5-aryl-7-styryl-5H-thiazolo[3,2-a]pyrimidin-6-yl)-3-arylprop-2-en-1-ones is reported.

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The prognostic value of schizontaemia in imported Plasmodium falciparum malaria

August 30, 2012 - 08:14 -- Kabogo Ndegwa
Author(s): 
van Wolfswinkel ME, de Mendonça Melo M, Vliegenthart-Jongbloed K, Koelewijn R, van Hellemond JJ, van Genderen PJ
Reference: 
Malaria Journal 2012, 11:301 (28 August 2012)

MalariaWorldAbsence of schizonts was found to be a specific marker for exclusion of severe malaria.

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Artemisinin resistance containment project in Thailand. II: responses to mefloquine-artesunate combination therapy among falciparum malaria patients in provinces bordering Cambodia

August 30, 2012 - 08:11 -- Kabogo Ndegwa
Author(s): 
Satimai W, Sudathip P, Vijakadge S, Khamsiriwatchara A, Sawang S, Potithavoranan T, Sangvichean A, Delacollette C, Singhasivanon P, Kaewkungwal J, Lawpoolsri S
Reference: 
Malaria Journal 2012, 11:300 (28 August 2012)

MalariaWorldAnti-malarial drug-resistant parasites should be closely monitored in the area along the Thai- Cambodian border.

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