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Plasmodium falciparum

Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda

August 27, 2012 - 07:22 -- Kabogo Ndegwa
Author(s): 
Tarning J, Kloprogge F, Piola P, Dhorda M, Muwanga S, Turyakira E, Nuengchamnong N, Nosten F, Day NP, White NJ, Guerin PJ, Lindegardh N
Reference: 
Malaria Journal 2012, 11:293 (22 August 2012)

MalariaWorldThe population pharmacokinetic properties of artemether and dihydroartemisinin, in pregnant women with uncomplicated P. falciparum malaria in Uganda, were described satisfactorily by a simultaneous drug-metabolite model without covariates.

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Longitudinal in vitro surveillance of Plasmodium falciparum sensitivity to common anti-malarials in Thailand between 1994 and 2010

August 27, 2012 - 07:19 -- Kabogo Ndegwa
Author(s): 
Parker D, Lerdprom R, Srisatjarak W, Yan G, Sattabongkot J, Wood J, Sirichaisinthop J, Cui L
Reference: 
Malaria Journal 2012, 11:290 (21 August 2012)

MalariaWorldParasite sensitivity to anti-malarials in Thailand is highly variable over time and largely mirrors official drug use policy.

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Anti-plasmodial activity of Dicoma tomentosa (Asteraceae) and identification of urospermal A-15- O-acetate as the main active compound

August 27, 2012 - 07:14 -- Kabogo Ndegwa
Author(s): 
Jansen O, Tits M, Angenot L, Nicolas J, De Mol P, Nikiema J, Frédérich M
Reference: 
Malaria Journal 2012, 11:289 (21 August 2012)

MalariaWorldThe present study highlighted the very promising anti-plasmodial activity of D. tomentosa and enabled to identify its main active compound, urospermal A-15-O-acetate.

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Broadly reactive antibodies specific for Plasmodium falciparum MSP-119 are associated with the protection of naturally exposed children against infection

August 27, 2012 - 07:08 -- Kabogo Ndegwa
Author(s): 
Dent AE, Moormann AM, Yohn CT, Kimmel RJ, Sumba PO, Vulule J, Long CA, Narum DL, Crabb BS, Kazura JW, Tisch DJ
Reference: 
Malaria Journal 2012, 11:287 (21 August 2012)

MalariaWorldVariant transcending IgG antibodies to MSP-119 are associated with protection from infection in children, but not adults.

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Lack of Evidence for Chloroquine-Resistant Plasmodium falciparum Malaria, Leogane, Haiti

August 23, 2012 - 15:10 -- Patrick Sampao
Author(s): 
Ami Neuberger, Kathleen Zhong, Kevin C Kain, and Eli Schwartz
Reference: 
Emerging Infectious Diseases, Volume 18, Number 9—September 2012

MalariaWorldAmong 49 patients with falciparum malaria, we found neither parasites carrying haplotypes associated with chloroquine resistance nor instances of chloroquine treatment failure.

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The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?

August 23, 2012 - 06:51 -- Kabogo Ndegwa
Author(s): 
Farfour E, Charlotte F, Settegrana C, Miyara M, Buffet P
Reference: 
Malaria Journal 2012, 11:285 (20 August 2012)

MalariaWorldThese observations represent a valuable step towards understanding sequestration patterns of P. falciparum gametocytes and may ultimately lead to novel transmission-blocking interventions.

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Effect of artesunate-mefloquine fixed-dose combination in malaria transmission in amazon basin communities

August 23, 2012 - 06:43 -- Kabogo Ndegwa
Author(s): 
Santelli AC, Ribeiro I, Daher A, Boulos M, Marchesini PB, La Corte dos Santos R, Lucena MB, Magalhães I, Leon AP, Junger W, Ladislau JL
Reference: 
Malaria Journal 2012, 11:286 (20 August 2012)

MalariaWorldIn the remote region of the Jurua valley, the early detection of malaria by health care workers and treatment with fixed-dose ASMQ was feasible and efficacious, and significantly reduced the incidence and morbidity of P. falciparum malaria.

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Timing of malaria messages for target audience on radio airwaves

August 22, 2012 - 13:49 -- Kabogo Ndegwa
Author(s): 
Batwala V, Magnussen P, Mirembe J, Mulogo E, Nuwaha F
Reference: 
Malaria Journal 2012, 11:283 (20 August 2012)

MalariaWorldPlanners of malaria radio interventions need to broadcast their messages within the two peak EAT of 12.00-14.00 and 18.00-23.00.

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Development, validation and evaluation of a rapid PCR-nucleic acid lateral flow immuno-assay for the detection of Plasmodium and the differentiation between Plasmodium falciparum and Plasmodium vivax

August 22, 2012 - 06:57 -- Kabogo Ndegwa
Author(s): 
Mens PF, Moers AP, de Bes LM, Flint J, Sak JR, Keereecharoen L, van Overmeir C, Verweij JJ, Hallett RL, Wihokhoen B, Proux S, Schallig HD, van Amerongen A
Reference: 
Malaria Journal 2012, 11:279 (17 August 2012)

MalariaWorldPCR-NALFIA is a sensitive, specific and robust assay able to identify Plasmodium species with good accuracy.

Autophagy-Related Atg8 Localizes to the Apicoplast of the Human Malaria Parasite Plasmodium falciparum

August 22, 2012 - 06:52 -- Kabogo Ndegwa
Author(s): 
Kei Kitamura, Chieko Kishi-Itakura, Takafumi Tsuboi, Shigeharu Sato, Kiyoshi Kita, Nobuo Ohta, Noboru Mizushima
Reference: 
PLoS ONE 7(8): e42977

MalariaWorldAutophagy is a membrane-mediated degradation process, which is governed by sequential functions of Atg proteins.

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