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Plasmodium falciparum

Artemisinin resistance containment project in Thailand. II: responses to mefloquine-artesunate combination therapy among falciparum malaria patients in provinces bordering Cambodia

August 30, 2012 - 08:11 -- Kabogo Ndegwa
Author(s): 
Satimai W, Sudathip P, Vijakadge S, Khamsiriwatchara A, Sawang S, Potithavoranan T, Sangvichean A, Delacollette C, Singhasivanon P, Kaewkungwal J, Lawpoolsri S
Reference: 
Malaria Journal 2012, 11:300 (28 August 2012)

MalariaWorldAnti-malarial drug-resistant parasites should be closely monitored in the area along the Thai- Cambodian border.

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Genetic variation in histidine rich proteins among Indian Plasmodium falciparum population: possible cause of variable sensitivity malaria of rapid diagnostic tests

August 30, 2012 - 08:05 -- Kabogo Ndegwa
Author(s): 
Kumar N, Singh JP, Pande V, Mishra N, Srivastava B, Kapoor R, Valecha N, Anvikar AR
Reference: 
Malaria Journal 2012, 11:298 (28 August 2012)

MalariaWorldThe results provide insights into the genetic diversity of Pfhrp2 and Pfhrp3 genes among Indian P. falciparum population and its relation to RDT sensitivity.

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Delayed Plasmodium falciparum clearance following artesunate-mefloquine combination therapy in Thailand, 1997-2007

August 30, 2012 - 07:58 -- Kabogo Ndegwa
Author(s): 
Vijaykadga S, Alker AP, Satimai W, MacArthur JR, Meshnick SR, Wongsrichanalai C
Reference: 
Malaria Journal 2012, 11:296 (28 August 2012)

MalariaWorldDelayed resolution of parasitaemia after AM treatment increased in eastern Thailand between 1997 and 2007, which may be an early manifestation of decreased artesunate susceptibility.

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Not Open Access | Metabolic Fingerprints of Serum, Brain, and Liver Are Distinct for Mice with Cerebral and Noncerebral Malaria: A 1H NMR Spectroscopy-Based Metabonomic Study

August 29, 2012 - 15:29 -- Patrick Sampao
Author(s): 
Soumita Ghosh, Arjun Sengupta, Shobhona Sharma, and Haripalsingh M. Sonawat
Reference: 
J. Proteome Res., July 27, 2012

MalariaWorldThe objective of this study was to search for metabolic changes/fingerprints of CM and identify the pathways that might be differentially altered in mice that succumbed to CM. The results show that brain, liver, and sera exhibit unique metabolic fingerprints for CM over NCM mice.

Not Open Access | Enhanced purification and characterization of the PfeIF4A (PfH45) helicase from Plasmodium Falciparum using a codon-optimised clone

August 29, 2012 - 15:02 -- Patrick Sampao
Author(s): 
Luke Evans, Darren Gowers, Keith Firman, James Youell
Reference: 
Protein Expression and Purification, Volume 85, Issue 1, September 2012, Pages 1-8

MalariaWorldWith the intention of investigating the DNA strand displacement properties of Plasmodium falciparum helicase PfeIF4A (formerly known as PfH45) a codon-optimized gene for expression in Escherichia coli has been produced. Several histidine-containing proteins with intrinsic helicase activity were captured from the bacterial sonicate by initial Ni2+-chromatography.

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Not Open Access | Distinguishing malaria and influenza: Early clinical features in controlled human experimental infection studies

August 29, 2012 - 14:37 -- Patrick Sampao
Author(s): 
Patrick J. Lillie, Christopher J.A. Duncan, Susanne H. Sheehy, Joel Meyer, Geraldine A. O'Hara, Sarah C. Gilbert, Adrian V.S. Hill
Reference: 
Travel Medicine and Infectious Disease, Volume 10, Issue 4, July 2012, Pages 192-196

MalariaWorldWe applied retrospectively the UK pH1N1/09 case definition to a unique cohort of healthy adult volunteers exposed to Plasmodium falciparummalaria or influenza to assess the predictive value of this case definition, and to explore the distinguishing clinical features of early phase infection with these pathogens under experimental conditions.

NOT Open Access | Antiplasmodial activities of 4-aminoquinoline–statine compounds

August 29, 2012 - 06:44 -- Kabogo Ndegwa
Author(s): 
Nadia Vaiana, Melissa Marzahn, Sergio Romeo, et al.
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 22, Issue 18, 15 September 2012, Pages 5915–5918

MalariaWorldWe report the discovery of new potent inhibitors of the growth of Plasmodium falciparum chloroquine (CQ)-resistant W2 strain.

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Performance of ¿VIKIA Malaria Ag Pf/Pan¿ (IMACCESS®), a new malaria rapid diagnostic test for detection of symptomatic malaria infections

August 27, 2012 - 07:43 -- Kabogo Ndegwa
Author(s): 
Chou M, Kim S, Khim N, Chy S, Sum S, Dourng D, Canier L, Nguon C, Menard D
Reference: 
Malaria Journal 2012, 11:295 (24 August 2012)

MalariaWorldThis new RDT performs similarly well as other commercially available tests (especially the CareStart Malaria[TRADE MARK SIGN] test, used as comparator), and conforms to the World Health Organization's recommendations for RDT performance. It is a good alternative tool for the diagnosis of malaria in endemic areas.

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Characterization of the Ubiquitylating Components of the Human Malaria Parasite’s Protein Degradation Pathway

August 27, 2012 - 07:30 -- Kabogo Ndegwa
Author(s): 
Duk-Won D. Chung, Nadia Ponts, Jacques Prudhomme, Elisandra M. Rodrigues, Karine G. Le Roch
Reference: 
PLoS ONE 7(8): e43477

MalariaWorldUbiquitin-dependent protein degradation within malarial parasites is a burgeoning field of interest due to several encouraging reports of proteasome inhibitors that were able to confer antimalarial activity.

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A framework for assessing the risk of resistance for anti-malarials in development

August 27, 2012 - 07:27 -- Kabogo Ndegwa
Author(s): 
Ding XC, Ubben D, Wells TN
Reference: 
Malaria Journal 2012, 11:292 (22 August 2012)

MalariaWorldResistance is a constant challenge for anti-infective drug development.

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