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Plasmodium falciparum

Malaria resistance genes are associated with the levels of IgG subclasses directed against Plasmodium falciparum blood-stage antigens in Burkina Faso

September 7, 2012 - 07:07 -- Kabogo Ndegwa
Author(s): 
Afridi S, Atkinson A, Garnier S, Fumoux F, Rihet P
Reference: 
Malaria Journal 2012, 11:308 (4 September 2012)

MalariaWorldTaken together, the results support the hypothesis that some polymorphisms affect malaria resistance through their effect on the acquired immune response, and pave the way towards further comprehension of genetic control of an individual's humoral response against malaria.

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Case Report: Artesunate for Severe Acute Plasmodium falciparum Infection in a Patient with Myasthenia Gravis

September 7, 2012 - 04:34 -- Patrick Sampao
Author(s): 
Nathalie Dournon, Pierre Buffet, Eric Caumes, Bernard Clair and Stéphane Jauréguiberry
Reference: 
Am J Trop Med Hyg 2012 87:435-436

MalariaWorldWe report a case of severe malaria in a patient with underlying myasthenia gravis who was successfully treated with artesunate.

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Analysis of the trap gene provides evidence for the role of elevation and vector abundance in the genetic diversity of Plasmodium relictum in Hawaii

September 5, 2012 - 06:55 -- Kabogo Ndegwa
Author(s): 
Farias ME, Atkinson CT, LaPointe DA, Jarvi SI
Reference: 
Malaria Journal 2012, 11:305 (3 September 2012)

MalariaWorldThe results of this study suggest that pathogen diversity in Hawaii may be driven by a complex interaction of factors including transmission rates, host immune pressures, and parasite-parasite competition.

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Eurartesim®: a guide to its use in the treatment of uncomplicated Plasmodium falciparum malaria

September 4, 2012 - 14:56 -- Patrick Sampao
Author(s): 
Keating, Gillian M
Reference: 
Drugs & Therapy Perspectives, Volume 28, Number 10, 1 October 2012 , pp. 1-5(5)

MalariaWorldThe Eurartesim® formulation of dihydroartemisinin/piperaquine is the only formulation to meet international good manufacturing practice standards.

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Not Open Access | A single amino acid change in the Plasmodium falciparum RH5 (PfRH5) human RBC binding sequence modifies its structure and determines species-specific binding activity

September 3, 2012 - 14:05 -- Patrick Sampao
Author(s): 
Gabriela Arévalo-Pinzón, Hernando Curtidor, Marina Muñoz, Manuel A. Patarroyo, Adriana Bermudez, Manuel E. Patarroyo
Reference: 
Vaccine, Volume 30, Issue 3, 11 January 2012, Pages 637-646

MalariaWorldOur results show that a single amino acid change in the HABP 36727 sequence modifies a peptide's 3D structure, thereby resulting in a loss of specific binding to human RBCs and its inhibition ability, while binding to Aotus RBC remains unmodified.

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Not Open Access | The effect of adjuvants on the immune response induced by a DBL4ɛ-ID4 VAR2CSA based Plasmodium falciparum vaccine against placental malaria

September 3, 2012 - 13:46 -- Patrick Sampao
Author(s): 
V.V. Pinto, A. Salanti, L.M. Joergensen, M. Dahlbäck, M. Resende, S.B. Ditlev, E.M. Agger, D.E. Arnot, T.G. Theander, M.A. Nielsen
Reference: 
Vaccine, Volume 30, Issue 3, 11 January 2012, Pages 572-579

MalariaWorldHere we tested the ability of DBL4ɛ-ID4 to induce binding-inhibitory antibodies when formulated with adjuvants approved for human use.

An Image-Based Drug Susceptibility Assay Targeting the Placental Sequestration of Plasmodium falciparum-Infected Erythrocytes

September 3, 2012 - 07:56 -- Kabogo Ndegwa
Author(s): 
Min-Je Ku, Fernando de M. Dossin, Michael A. E. Hansen, Auguste Genovesio, Lawrence Ayong, Lucio H. Freitas-Junior
Reference: 
PLoS ONE 7(8): e41765

MalariaWorldPlacental malaria is a significant cause of all malaria-related deaths globally for which no drugs have been developed to specifically disrupt its pathogenesis.

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NOT Open Access | Tandem synthesis and in vitro antiplasmodial evaluation of new naphtho[2,1-d]thiazole derivatives

September 3, 2012 - 07:53 -- Kabogo Ndegwa
Author(s): 
Anita Cohen, Pierre Verhaeghe, Maxime D. Crozet, Sébastien Hutter, Pascal Rathelot, Patrice Vanelle, Nadine Azas
Reference: 
European Journal of Medicinal Chemistry, Volume 55, September 2012, Pages 315–324

MalariaWorldA series of naphtho[2,1-d]thiazoles was prepared in good yields under microwave irradiation with an original protocol combining tandem direct arylation and intramolecular Knoevenagel reaction on 1,3-thiazole derivatives.

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NOT Open Access | One pot efficient diversity oriented synthesis of polyfunctional styryl thiazolopyrimidines and their bio-evaluation as antimalarial and anti-HIV agents

September 3, 2012 - 07:41 -- Kabogo Ndegwa
Author(s): 
Seerat Fatima, Anindra Sharma, Reshu Saxena, Rajkamal Tripathi, Sanjeev K. Shukla, Swaroop Kumar Pandey, Renu Tripathi, Rama P. Tripathi
Reference: 
European Journal of Medicinal Chemistry, Volume 55, September 2012, Pages 195–204

MalariaWorldAn efficient one pot synthesis of a series of pluripotent (E)-1-(3-methyl-5-aryl-7-styryl-5H-thiazolo[3,2-a]pyrimidin-6-yl)-3-arylprop-2-en-1-ones is reported.

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The prognostic value of schizontaemia in imported Plasmodium falciparum malaria

August 30, 2012 - 08:14 -- Kabogo Ndegwa
Author(s): 
van Wolfswinkel ME, de Mendonça Melo M, Vliegenthart-Jongbloed K, Koelewijn R, van Hellemond JJ, van Genderen PJ
Reference: 
Malaria Journal 2012, 11:301 (28 August 2012)

MalariaWorldAbsence of schizonts was found to be a specific marker for exclusion of severe malaria.

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