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Plasmodium falciparum

Status of potential PfATP6 molecular markers for artemisinin resistance in Suriname

September 13, 2012 - 13:26 -- Kabogo Ndegwa
Author(s): 
Adhin MR, Labadie-Bracho M, Vreden SG
Reference: 
Malaria Journal 2012, 11:322 (11 September 2012)

MalariaWorldAll investigated isolates before and after the adoption of the ACT-regimen and independent of endemic region harbored the wild-type genotype for the three investigated polymorphisms.

NOT Open Access | Comparative Ex Vivo Activity of Novel Endoperoxides in Multidrug-Resistant Plasmodium falciparum and P. vivax

September 13, 2012 - 13:16 -- Kabogo Ndegwa
Author(s): 
Jutta Marfurt, Ferryanto Chalfein, Ric N. Price, et al.
Reference: 
Antimicrob. Agents Chemother. October 2012 vol. 56 no. 10 5258-5263

 

MalariaWorldThe declining efficacy of artemisinin derivatives against Plasmodium falciparum highlights the urgent need to identify alternative highly potent compounds for the treatment of malaria.

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NOT Open Access | CpG-containing oligodeoxynucleotides increases resistance of Anopheles mosquitoes to Plasmodium infection

September 12, 2012 - 11:13 -- Kabogo Ndegwa
Author(s): 
Henrique Silveira, Ana Gabriel, Susana Ramos, Joel Palma, Rute Felix, Ana Custódio, L. Vincent Collins
Reference: 
Insect Biochemistry and Molecular Biology, Volume 42, Issue 10, October 2012, Pages 758–765

MalariaWorldUnmethylated CpG dinucleotide motifs in bacterial DNA or in synthetic oligodeoxynucleotides (ODN) are potent stimulators of the vertebrate innate immune system.

Not Open Access | The walking dead: Is hydroethidine a suitable viability dye for intra-erythrocytic Plasmodium falciparum?

September 12, 2012 - 04:30 -- Patrick Sampao
Author(s): 
Dewaldt Engelbrecht, Thérèsa Louise Coetzer
Reference: 
Parasitology International, Volume 61, Issue 4, December 2012, Pages 731-734

MalariaWorldWe compared flow cytometric quantification by hydroethidine and thiazole orange in P. falciparum.

Not Open Access | Toward understanding the role of mitochondrial complex II in the intraerythrocytic stages of Plasmodium falciparum: Gene targeting of the Fp subunit

September 12, 2012 - 04:25 -- Patrick Sampao
Author(s): 
Takeshi Q. Tanaka, Makoto Hirai, Yoh-ichi Watanabe, Kiyoshi Kita
Reference: 
Parasitology International, Volume 61, Issue 4, December 2012, Pages 726-728

MalariaWorldTo elucidate the physiological role of Plasmodium falciparum mitochondrial complex II (succinate-ubiquinone reductase (SQR) or succinate dehydrogenase (SDH)) in the TCA cycle, the gene for the flavoprotein subunit (Fp) of the enzyme, pfsdha (P.falciparum gene for SDH subunit A, PlasmoDB ID: PF3D7_1034400) was disrupted.

Impact of pre-existing MSP142-allele specific immunity on potency of an erythrocytic Plasmodium falciparum vaccine

September 11, 2012 - 07:01 -- Kabogo Ndegwa
Author(s): 
Bergmann-Leitner ES, Duncan EH, Mease RM, Angov E
Reference: 
Malaria Journal 2012, 11:315 (7 September 2012)

MalariaWorldThe development of a more broadly efficacious MSP1 based vaccine may be hindered by clonally imprinted p33 responses mainly restricted at the T cell level.

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Investigation of volatile organic biomarkers derived from Plasmodium falciparum in vitro

September 11, 2012 - 06:54 -- Kabogo Ndegwa
Author(s): 
Wong RP, Flemati GR, Davis TM
Reference: 
Malaria Journal 2012, 11:314 (7 September 2012)

MalariaWorldFuture in vivo studies analysing the breath of patients with severe malaria who are harbouring a parasite biomass that is significantly greater than achievable in vitro may yet reveal specific clinically-useful volatile chemical biomarkers.

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Optimization of flow cytometric detection and cell sorting of transgenic Plasmodium parasites using interchangeable optical filters

September 7, 2012 - 07:43 -- Kabogo Ndegwa
Author(s): 
Vorobjev IA, Buchholz K, Prabhat P, Ketman K, Egan E, Marti M, Duraisingh MT, Barteneva NS
Reference: 
Malaria Journal 2012, 11:312 (5 September 2012)

MalariaWorldFilter optimization is particularly important for applications where the FP signal and percentage of positive events are relatively low, such as analysis of parasite-infected samples with in the intention of gene-expression profiling and analysis.

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Effects of malaria volunteer training on coverage and timeliness of diagnosis: a cluster randomized controlled trial in Myanmar

September 7, 2012 - 07:30 -- Kabogo Ndegwa
Author(s): 
Ohnmar -, Tun-Min -, San-Shwe -, Than-Win -, Chongsuvivatwong V
Reference: 
Malaria Journal 2012, 11:309 (4 September 2012)

MalariaWorldThe results show that implementing volunteer programmes to improve the coverage of accurate and timely diagnosis with RDT and early treatment may be beneficial but the timeliness of detection and sustainability must be improved.

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Malaria resistance genes are associated with the levels of IgG subclasses directed against Plasmodium falciparum blood-stage antigens in Burkina Faso

September 7, 2012 - 07:07 -- Kabogo Ndegwa
Author(s): 
Afridi S, Atkinson A, Garnier S, Fumoux F, Rihet P
Reference: 
Malaria Journal 2012, 11:308 (4 September 2012)

MalariaWorldTaken together, the results support the hypothesis that some polymorphisms affect malaria resistance through their effect on the acquired immune response, and pave the way towards further comprehension of genetic control of an individual's humoral response against malaria.

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