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Plasmodium falciparum

Not Open Access | Conformational co-dependence between Plasmodium berghei LCCL proteins promotes complex formation and stability

October 1, 2012 - 17:26 -- Patrick Sampao
Author(s): 
Sadia Saeed, Annie Z. Tremp, Johannes T. Dessens
Reference: 
Molecular and Biochemical Parasitology, Volume 185, Issue 2, October 2012, Pages 170-173

MalariaWorld Here, we investigate this in Plasmodium berghei by crossing a PbLAP1 null mutant parasite with a parasite line expressing GFP-tagged PbLAP3 that displays strong fluorescence in gametocytes.

NOT Open Access | Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline

September 19, 2012 - 12:45 -- Kabogo Ndegwa
Author(s): 
Manolo Casagrande, Anna Barteselli, Nicoletta Basilico, Silvia Parapini, Donatella Taramelli, Anna Sparatore
Reference: 
Bioorganic & Medicinal Chemistry, Volume 20, Issue 19, 1 October 2012, Pages 5965–5979

MalariaWorldWith the aim to investigate the effect of different heterocyclic rings linked to the 4-aminoquinoline nucleus on the antimalarial activity, a set of 7-chloro-N-(heteroaryl)-methyl-4-aminoquinoline and 7-chloro-N-(heteroaryl)-4-aminoquinoline was synthesized and tested in vitro against D-10 (CQ-S) and W-2 (CQ-R) strains of Plasmodium falciparum.

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An Exported Heat Shock Protein 40 Associates with Pathogenesis-Related Knobs in Plasmodium falciparum Infected Erythrocytes

September 18, 2012 - 07:37 -- Kabogo Ndegwa
Author(s): 
Pragyan Acharya, Shweta Chaubey, Manish Grover, Utpal Tatu
Reference: 
PLoS ONE 7(9): e44605

MalariaWorldCell surface structures termed knobs are one of the most important pathogenesis related protein complexes deployed by the malaria parasite Plasmodium falciparum at the surface of the infected erythrocyte.

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Optimizing the HRP-2 in vitro malaria drug susceptibility assay using a reference clone to improve comparisons of Plasmodium falciparum field isolates

September 18, 2012 - 07:03 -- Kabogo Ndegwa
Author(s): 
Rutvisuttinunt W, Chaorattanakawee S, Tyner SD, Teja-isavadharm P, Se Y, Yingyuen K, Chaichana P, Bethell D, Walsh DS, Lon C, Fukuda M, Socheat D, Noedl H, Schaecher K, Saunders DL
Reference: 
Malaria Journal 2012, 11:325 (13 September 2012)

MalariaWorldThe W2 reference clone improved the interpretability of field isolate susceptibility from the immediate ex vivo HRP-2 assay from areas of artemisinin resistance.

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Status of potential PfATP6 molecular markers for artemisinin resistance in Suriname

September 13, 2012 - 13:26 -- Kabogo Ndegwa
Author(s): 
Adhin MR, Labadie-Bracho M, Vreden SG
Reference: 
Malaria Journal 2012, 11:322 (11 September 2012)

MalariaWorldAll investigated isolates before and after the adoption of the ACT-regimen and independent of endemic region harbored the wild-type genotype for the three investigated polymorphisms.

NOT Open Access | Comparative Ex Vivo Activity of Novel Endoperoxides in Multidrug-Resistant Plasmodium falciparum and P. vivax

September 13, 2012 - 13:16 -- Kabogo Ndegwa
Author(s): 
Jutta Marfurt, Ferryanto Chalfein, Ric N. Price, et al.
Reference: 
Antimicrob. Agents Chemother. October 2012 vol. 56 no. 10 5258-5263

 

MalariaWorldThe declining efficacy of artemisinin derivatives against Plasmodium falciparum highlights the urgent need to identify alternative highly potent compounds for the treatment of malaria.

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NOT Open Access | CpG-containing oligodeoxynucleotides increases resistance of Anopheles mosquitoes to Plasmodium infection

September 12, 2012 - 11:13 -- Kabogo Ndegwa
Author(s): 
Henrique Silveira, Ana Gabriel, Susana Ramos, Joel Palma, Rute Felix, Ana Custódio, L. Vincent Collins
Reference: 
Insect Biochemistry and Molecular Biology, Volume 42, Issue 10, October 2012, Pages 758–765

MalariaWorldUnmethylated CpG dinucleotide motifs in bacterial DNA or in synthetic oligodeoxynucleotides (ODN) are potent stimulators of the vertebrate innate immune system.

Not Open Access | The walking dead: Is hydroethidine a suitable viability dye for intra-erythrocytic Plasmodium falciparum?

September 12, 2012 - 04:30 -- Patrick Sampao
Author(s): 
Dewaldt Engelbrecht, Thérèsa Louise Coetzer
Reference: 
Parasitology International, Volume 61, Issue 4, December 2012, Pages 731-734

MalariaWorldWe compared flow cytometric quantification by hydroethidine and thiazole orange in P. falciparum.

Not Open Access | Toward understanding the role of mitochondrial complex II in the intraerythrocytic stages of Plasmodium falciparum: Gene targeting of the Fp subunit

September 12, 2012 - 04:25 -- Patrick Sampao
Author(s): 
Takeshi Q. Tanaka, Makoto Hirai, Yoh-ichi Watanabe, Kiyoshi Kita
Reference: 
Parasitology International, Volume 61, Issue 4, December 2012, Pages 726-728

MalariaWorldTo elucidate the physiological role of Plasmodium falciparum mitochondrial complex II (succinate-ubiquinone reductase (SQR) or succinate dehydrogenase (SDH)) in the TCA cycle, the gene for the flavoprotein subunit (Fp) of the enzyme, pfsdha (P.falciparum gene for SDH subunit A, PlasmoDB ID: PF3D7_1034400) was disrupted.

Impact of pre-existing MSP142-allele specific immunity on potency of an erythrocytic Plasmodium falciparum vaccine

September 11, 2012 - 07:01 -- Kabogo Ndegwa
Author(s): 
Bergmann-Leitner ES, Duncan EH, Mease RM, Angov E
Reference: 
Malaria Journal 2012, 11:315 (7 September 2012)

MalariaWorldThe development of a more broadly efficacious MSP1 based vaccine may be hindered by clonally imprinted p33 responses mainly restricted at the T cell level.

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