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Plasmodium falciparum

Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum

October 10, 2012 - 16:16 -- Patrick Sampao
Author(s): 
Shaun B Reeksting, Ingrid B. Müller, Pieter B Burger, Emmanuel S Burgos, Laurent Salmon, Abraham Izak Louw, Lyn-Marie Birkholtz and Carsten Wrenger
Reference: 
Biochem. J. (2012)

MalariaWorldWe demonstrate that d-erythrose 4-phosphate (E4P) inhibits PfPdx1 in a dose dependent manner. We propose that the acyclic phospho-sugar E4P, with a C1 aldehyde group similar to acyclic R5P, could interfere with R5P imine bond formations in the PfPdx1 reaction mechanism.

Assessment of the Molecular Marker of Plasmodium falciparum Chloroquine Resistance (Pfcrt) in Senegal after Several Years of Chloroquine Withdrawal

October 10, 2012 - 16:11 -- Patrick Sampao
Author(s): 
Magatte Ndiaye, Babacar Faye, Roger Tine, Jean Louis Ndiaye, Aminata Lo, Annie Abiola, Yemou Dieng, Daouda Ndiaye, Rachel Hallett, Michael Alifrangis and Oumar Gaye
Reference: 
Am J Trop Med Hyg 2012 87:640-645

MalariaWorldAfter several years of CQ withdrawal, the current study wished to determine the level of CQ resistance at the molecular level in selected sites in Senegal, because the scientific community is interested in using CQ again.

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Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum

October 10, 2012 - 08:58 -- Kabogo Ndegwa
Author(s): 
Nicholas A. Malmquist, Thomas A. Moss, Salah Mecheri, Artur Scherf, and Matthew J. Fuchter
Reference: 
PNAS October 9, 2012 vol. 109 no. 41 16708-16713

MalariaWorldEpigenetic factors such as histone methylation control the developmental progression of malaria parasites during the complex life cycle in the human host.

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Long-term storage limits PCR-based analyses of malaria parasites in archival dried blood spots

October 9, 2012 - 13:36 -- Kabogo Ndegwa
Author(s): 
Hwang J, Jaroensuk J, Leimanis ML, Russell B, McGready R, Day N, Snounou G, Nosten F, Imwong M
Reference: 
Malaria Journal 2012, 11:339 (8 October 2012)

MalariaWorldThe average length of DNA fragments that can be recovered from dried blood spots decrease with storage time.

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Surveillance of the efficacy of artemetherlumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum among children under five in Togo, 2005-2009

October 9, 2012 - 13:34 -- Kabogo Ndegwa
Author(s): 
Dorkenoo MA, Barrette A, Agbo YM, Bogreau H, Kutoati S, Sodahlon YK, Morgah K
Reference: 
Malaria Journal 2012, 11:338 (8 October 2012)

MalariaWorldBoth formulations of artemisinin-based combination therapy were effective over time and no severe adverse events related to the treatment were reported during the studies.

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Molecular Basis for Genetic Resistance of Anopheles gambiae to Plasmodium: Structural Analysis of TEP1 Susceptible and Resistant Alleles

October 8, 2012 - 08:53 -- Kabogo Ndegwa
Author(s): 
Binh V. Le, Marni Williams, Shankar Logarajah, Richard H. G. Baxter
Reference: 
PLoS Pathog 8(10): e1002958

MalariaWorldThioester-containing protein 1 (TEP1) is a central component in the innate immune response of Anopheles gambiae to Plasmodium infection.

Not Open Access | Conformational co-dependence between Plasmodium berghei LCCL proteins promotes complex formation and stability

October 1, 2012 - 17:26 -- Patrick Sampao
Author(s): 
Sadia Saeed, Annie Z. Tremp, Johannes T. Dessens
Reference: 
Molecular and Biochemical Parasitology, Volume 185, Issue 2, October 2012, Pages 170-173

MalariaWorld Here, we investigate this in Plasmodium berghei by crossing a PbLAP1 null mutant parasite with a parasite line expressing GFP-tagged PbLAP3 that displays strong fluorescence in gametocytes.

NOT Open Access | Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline

September 19, 2012 - 12:45 -- Kabogo Ndegwa
Author(s): 
Manolo Casagrande, Anna Barteselli, Nicoletta Basilico, Silvia Parapini, Donatella Taramelli, Anna Sparatore
Reference: 
Bioorganic & Medicinal Chemistry, Volume 20, Issue 19, 1 October 2012, Pages 5965–5979

MalariaWorldWith the aim to investigate the effect of different heterocyclic rings linked to the 4-aminoquinoline nucleus on the antimalarial activity, a set of 7-chloro-N-(heteroaryl)-methyl-4-aminoquinoline and 7-chloro-N-(heteroaryl)-4-aminoquinoline was synthesized and tested in vitro against D-10 (CQ-S) and W-2 (CQ-R) strains of Plasmodium falciparum.

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An Exported Heat Shock Protein 40 Associates with Pathogenesis-Related Knobs in Plasmodium falciparum Infected Erythrocytes

September 18, 2012 - 07:37 -- Kabogo Ndegwa
Author(s): 
Pragyan Acharya, Shweta Chaubey, Manish Grover, Utpal Tatu
Reference: 
PLoS ONE 7(9): e44605

MalariaWorldCell surface structures termed knobs are one of the most important pathogenesis related protein complexes deployed by the malaria parasite Plasmodium falciparum at the surface of the infected erythrocyte.

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Optimizing the HRP-2 in vitro malaria drug susceptibility assay using a reference clone to improve comparisons of Plasmodium falciparum field isolates

September 18, 2012 - 07:03 -- Kabogo Ndegwa
Author(s): 
Rutvisuttinunt W, Chaorattanakawee S, Tyner SD, Teja-isavadharm P, Se Y, Yingyuen K, Chaichana P, Bethell D, Walsh DS, Lon C, Fukuda M, Socheat D, Noedl H, Schaecher K, Saunders DL
Reference: 
Malaria Journal 2012, 11:325 (13 September 2012)

MalariaWorldThe W2 reference clone improved the interpretability of field isolate susceptibility from the immediate ex vivo HRP-2 assay from areas of artemisinin resistance.

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