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Plasmodium falciparum

Not Open Access | First-Trimester Plasmodium falciparum Infections Display a Typical “Placental” Phenotype

November 21, 2012 - 16:52 -- NOT Open Access
Author(s): 
Justin Doritchamou, Gwladys Bertin, Azizath Moussiliou, Pascal Bigey, Firmine Viwami, Sem Ezinmegnon, Nadine Fievet, Achille Massougbodji, Philippe Deloron, and Nicaise Tuikue Ndam
Reference: 
J Infect Dis. (2012) 206 (12): 1911-1919.
MalariaWorld

 

Here, we investigated the transcription pattern of var genes by real-time polymerase chain reaction, the expression of VAR2CSA, protein by flow cytometry, and the CSA-binding ability of IEs collected at different stages of pregnancy using a static-based Petri dish assay.

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Not Open Access | Analysis of immunogenicity of different protein groups from malaria parasite Plasmodium falciparum

November 12, 2012 - 15:14 -- NOT Open Access
Author(s): 
KatarzynaKrzyczmonik, MichałŚwitnicki, SzymonKaczanowski
Reference: 
Infection, Genetics and Evolution, Volume 12, Issue 8, December 2012, Pages 1911-1916
MalariaWorld

We confirmed the expectations that proteins containing IEDB epitopes are subject to stronger diversifying selection which is evidenced by higher pN/pS ratio. A stage characterized by the highest average pN/pS ratio is that of the sporozoite.

Evaluation of the malaria rapid diagnostic test SDFK90: detection of both PfHRP2 and Pf-pLDH

November 11, 2012 - 11:50 -- Open Access
Author(s): 
Heutmekers M, Gillet P, Cnops L, Bottieau E, Van Esbroeck M, Maltha J, Jacobs J
Reference: 
Malaria Journal 2012, 11:359 (29 October 2012)
MalariaWorld

The combination of PfHRP2 and Pf-pLDH ensures a low detection threshold and counters potential problems of PfHRP2 detection such as gene deletions and the prozone effect.

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Simulation of malaria epidemiology and control in the highlands of western Kenya

November 11, 2012 - 11:31 -- Open Access
Author(s): 
Stuckey EM, Stevenson JC, Cooke MK, Owaga C, Marube E, Oando G, Hardy D, Drakeley C, Smith TA, Cox J, Chitnis N
Reference: 
Malaria Journal 2012, 11:357 (29 October 2012)
MalariaWorld

The OpenMalaria model of P. falciparum transmission can be used to simulate the impact of different combinations of current and potential control interventions to help plan malaria control in this low transmission setting.

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In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam

November 11, 2012 - 10:28 -- Open Access
Author(s): 
Hien TT, Thuy-Nhien NT, Wolbers M, et al.
Reference: 
Malaria Journal 2012, 11:355 (26 October 2012)
MalariaWorld

This study demonstrated faster P. falciparum parasite clearance in southern Vietnam than in western Cambodia but slower clearance in comparison with historical data from Vietnam

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The Dynamics of Naturally Acquired Immunity to Plasmodium falciparum Infection

November 11, 2012 - 09:55 -- Open Access
Author(s): 
Mykola Pinkevych, Janka Petravic, Kiprotich Chelimo, James W. Kazura, Ann M. Moormann, Miles P. Davenport
Reference: 
PLoS Comput Biol 8(10): e1002729
MalariaWorld

Severe malaria occurs predominantly in young children and immunity to clinical disease is associated with cumulative exposure in holoendemic settings

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Plasmodium falciparum Gametocyte Development 1 (Pfgdv1) and Gametocytogenesis Early Gene Identification and Commitment to Sexual Development

November 11, 2012 - 09:49 -- Open Access
Author(s): 
Saliha Eksi, Belinda J. Morahan, Kim C. Williamson, et al.
Reference: 
PLoS Pathog 8(10): e1002964
MalariaWorld

Malaria transmission requires the production of male and female gametocytes in the human host followed by fertilization and sporogonic development in the mosquito midgut.

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Review: Shape-shifting gametocytes: how and why does P. falciparum go banana-shaped?

October 24, 2012 - 16:16 -- Open Access
Author(s): 
Matthew W.A. Dixon, Megan K. Dearnley, Eric Hanssen, Tim Gilberger, Leann Tilley
Reference: 
Trends in Parasitology, Volume 28, Issue 11, November 2012, Pages 471-478

MalariaWorldWe describe the machinery that elongates falciparum gametocytes and discuss its relation with the machinery that elongates the invasive zoites. We address the question – why do falciparum malaria gametocytes go banana-shaped? 

Intervention Review: Primaquine for reducing Plasmodium falciparum transmission

October 24, 2012 - 15:51 -- Patrick Sampao
Author(s): 
Patricia M Graves, Hellen Gelband, Paul Garner
Reference: 
Cochrane Database of Systematic Reviews 2012, Issue 9. Art. No.: CD008152

MalariaWorldTwo authors (PMG and HG) independently screened all abstracts, applied inclusion criteria, and abstracted data. We sought data on the effect of PQ on malaria transmission intensity, participant infectiousness, the number of participants with gametocytes, and gametocyte density over time. 

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Quinine localizes to a non-acidic compartment within the food vacuole of the malaria parasite Plasmodium falciparum

October 23, 2012 - 14:56 -- Patrick Sampao
Author(s): 
Bohórquez EB, Chua M, Meshnick SR
Reference: 
Malaria Journal 2012, 11:350 (22 October 2012)

MalariaWorldFluorescence microscopy was used to evaluate the subcellular localization of quinine in parasites containing different pfmdr1 copy numbers to determine if copy number of the gene affects drug localization.

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