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Plasmodium falciparum

Lack of effect of intermittent preventive treatment for malaria in pregnancy and intense drug resistance in western Uganda

September 30, 2015 - 16:48 -- Open Access
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Author(s): 
Vera Braun, Eva Rempis, Frank Mockenhaupt, et al.
Reference: 
Malaria Journal 2015, 14:372 (26 September 2015)

In Fort Portal, Uganda, reported use of IPTp with SP does not provide an observable benefit. The molecular markers of P. falciparum indicate high grade SP resistance reaching the threshold set by WHO for the discontinuation of IPTp with SP.

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Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®)

April 20, 2015 - 17:26 -- Open Access
Author(s): 
Alfred B Tiono, Halidou Tinto, Kamal Hamed, et al.
Reference: 
Malaria Journal 2015, 14:157 (15 April 2015)

A three-day regimen of AL dispersible formulation was efficacious and generally well tolerated in infants weighing <5 kg with uncomplicated P. falciparum malaria, but artemether and dihydroartemisinin exposures could not be supported by the preclinical safety margins for neurotoxicity.

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G6PD gene variants and its association with malaria in a Sri Lankan population

March 2, 2015 - 18:53 -- Open Access
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Author(s): 
Rajika L Dewasurendra, Kirk A Rockett, S Fernando, Richard Carter, Dominic P Kwiatkowski, Nadira D Karunaweera, in collaboration with the MalariaGEN Consortium
Reference: 
Malaria Journal 2015, 14:93 (22 February 2015)

This is the most detailed survey of G6PD SNPs in a Sri Lankan population undertaken so far that enabled novel description of single nucleotide polymorphisms within the G6PD gene.

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Not Open Access | Marked Decline in Malaria Prevalence among Pregnant Women and Their Offspring from 1996 to 2010 on the South Kenyan Coast

December 11, 2013 - 17:49 -- NOT Open Access
Author(s): 
Benjamin C. Kalayjian, Indu Malhotra, Peter Mungai, Penny Holding and Christopher L. King
Reference: 
Am J Trop Med Hyg 2013 89:1129-1134

These results show a profound reduction in malaria transmission in coastal Kenya.

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Not Open Access | Monitoring Malaria Vector Control Interventions: Effectiveness of Five Different Adult Mosquito Sampling Methods

September 13, 2013 - 18:23 -- NOT Open Access
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Author(s): 
Shirley A. Onyango , Uriel Kitron , Peter Mungai , Eric M. Muchiri , Elizabeth Kokwaro , Charles H. King , and Francis M. Mutuku
Reference: 
Journal of Medical Entomology 50(5):1140-1151. 2013
MalariaWorld

The objective of our study was to identify the most efficient mosquito sampling tool(s) for routine vector surveillance for malaria and lymphatic filariasis transmission in coastal Kenya.

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A longitudinal study on anaemia in children with Plasmodium falciparum infection in the Mount Cameroon region: prevalence, risk factors and perceptions by caregivers

March 6, 2013 - 16:16 -- Open Access
Author(s): 
Sumbele IU, Samje M, Nkuo-Akenji T
Reference: 
BMC Infectious Diseases 2013, 13:123 (5 March 2013)
MalariaWorld

A longitudinal study was conducted among 351 Plasmodium falciparum positive children to determine the prevalence, risk factors and the perception of anaemia by the caregivers in a semi-rural community. The investigative methods included the use of a structured questionnaire, clinical evaluation and laboratory investigations.

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Plasmodium falciparum Malaria Elicits Inflammatory Responses that Dysregulate Placental Amino Acid Transport

February 11, 2013 - 18:03 -- Open Access
Author(s): 
Philippe Boeuf, Elizabeth H. Aitken, Upeksha Chandrasiri, Caroline Lin Lin Chua, Bernie McInerney, Leon McQuade, Michael Duffy, Malcolm Molyneux, Graham Brown, Jocelyn Glazier, Stephen J. Rogerson
Reference: 
PLoS Pathog 9(2): e1003153
MalariaWorld

Overall, our data suggest that the fetoplacental unit responds to PM by altering its placental amino acid transport to maintain adequate fetal growth. However, IV more profoundly compromises placental amino acid transport function, leading to FGR. Our study offers the first pathogenetic explanation for FGR in PM.

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Artesunate-amodiaquine efficacy in Congolese children with acute uncomplicated falciparum malaria in Brazzaville

February 11, 2013 - 16:29 -- Open Access
Author(s): 
Ndounga M, Mayengue P, Casimiro P, Loumouamou D, Basco LK, Ntoumi F, Brasseur P
Reference: 
Malaria Journal 2013, 12:53 (5 February 2013)
MalariaWorld

This study has shown the high efficacy of AS + AQ in Congolese patients of all ages with acute uncomplicated falciparum malaria and serves as the baseline efficacy and tolerance of this ACT in Brazzaville.

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Not Open Access | Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold

November 25, 2012 - 14:20 -- NOT Open Access
Author(s): 
Vanida Choomuenwai, Katherine T. Andrews, Rohan A. Davis
Reference: 
Bioorganic & Medicinal Chemistry, Volume 20, Issue 24, 15 December 2012, Pages 7167-7174
MalariaWorld

This compound displayed moderate cytotoxicity against neonatal foreskin fibroblast (NFF) cells with an IC50 of 15.6 μM.

Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo

November 25, 2012 - 14:02 -- Open Access
Author(s): 
Kamkumo RG, Ngoutane AM, Tchokouaha LR, Fokou PV, Madiesse EA, Legac J, Kezetas JJ, Lenta BN, Boyom FF, Dimo T, Mbacham WF, Gut J, Rosenthal PJ
Reference: 
Malaria Journal 2012, 11:382 (21 November 2012)
MalariaWorld

This paper describes the results of an anti-malarial activity-driven investigation of the fruits of this Cameroonian plant.

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