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Plasmodium falciparum

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

October 18, 2012 - 06:47 -- Kabogo Ndegwa
Author(s): 
Yongyuth Yuthavong, Bongkoch Tarnchompoo, David Matthews, et al.
Reference: 
PNAS October 16, 2012 vol. 109 no. 42 16823-16828

MalariaWorldMalarial dihydrofolate reductase (DHFR) is the target of antifolate antimalarial drugs such as pyrimethamine and cycloguanil, the clinical efficacy of which have been compromised by resistance arising through mutations at various sites on the enzyme.

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Not Open Access |Genomic Sequencing of Plasmodium falciparum Malaria Parasites from Senegal Reveals the Demographic History of the Population

October 17, 2012 - 16:08 -- Patrick Sampao
Author(s): 
Hsiao-Han Chang, Daniel J. Park, Daniel L. Hartl, et al.
Reference: 
Mol Biol Evol (2012) 29 (11): 3427-3439.

MalariaWorldWe show that there is no significant population structure among these Senegal sampling sites. By fitting demographic models to the synonymous allele-frequency spectrum, we also estimated a major 60-fold population expansion of this parasite population ∼20,000–40,000 years ago.

SNP Genotyping Identifies New Signatures of Selection in a Deep Sample of West African Plasmodium falciparum Malaria Parasites

October 17, 2012 - 16:04 -- Patrick Sampao
Author(s): 
Alfred Amambua-Ngwa, Daniel J. Park, Stephen F. Schaffner, et al.
Reference: 
Molecular Biology and Evolution, Volume 29, Issue 11 Pp. 3249-3253.

MalariaWorldWe discuss the value of deep population-specific genomic analyses for identifying selection signals within sampled endemic populations of parasites, which may correspond to local selection pressures such as distinctive therapeutic regimes or mosquito vectors.

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Feature Article: Evidence for additive and interaction effects of host genotype and infection in malaria

October 17, 2012 - 07:53 -- Kabogo Ndegwa
Author(s): 
Youssef Idaghdour, Jacklyn Quinlan, Jean-Philippe Goulet, Joanne Berghout, Elias Gbeha, Vanessa Bruat, Thibault de Malliard, Jean-Christophe Grenier, Selma Gomez, Philippe Gros, Mohamed Chérif Rahimy, Ambaliou Sanni, and Philip Awadalla
Reference: 
PNAS October 16, 2012 vol. 109 no. 42 16786-16793

MalariaWorldThe host mechanisms responsible for protection against malaria remain poorly understood, with only a few protective genetic effects mapped in humans.

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NOT Open Access | In Vitro Activity of Fluorescent Dyes against Asexual Blood Stages of Plasmodium falciparum

October 17, 2012 - 07:47 -- Kabogo Ndegwa
Author(s): 
Fanny Joanny, Jana Held, and Benjamin Mordmüller
Reference: 
Antimicrob. Agents Chemother. November 2012 vol. 56 no. 11 5982-5985

MalariaWorldMany successful antimicrobial drugs originate from synthetic dyes.

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Cell Biological Characterization of the Malaria Vaccine Candidate Trophozoite Exported Protein 1

October 16, 2012 - 07:22 -- Kabogo Ndegwa
Author(s): 
Caroline Kulangara, Samuel Luedin, Olivier Dietz, Sebastian Rusch, Geraldine Frank, Dania Mueller, Mirjam Moser, Andrey V. Kajava, Giampietro Corradin, Hans-Peter Beck, Ingrid Felger
Reference: 
PLoS ONE 7(10): e46112

MalariaWorldIn a genome-wide screen for alpha-helical coiled coil motifs aiming at structurally defined vaccine candidates we identified PFF0165c.

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Initial Characterization of the Pf-Int Recombinase from the Malaria Parasite Plasmodium falciparum

October 16, 2012 - 07:17 -- Kabogo Ndegwa
Author(s): 
Mehdi Ghorbal, Christine Scheidig-Benatar, Salma Bouizem, Christophe Thomas, Genevieve Paisley, Claire Faltermeier, Melanie Liu, Artur Scherf, Jose-Juan Lopez-Rubio, Deshmukh N. Gopaul
Reference: 
PLoS ONE 7(10): e46507

MalariaWorldOur data identify for the first time a malaria parasite gene with structural and functional features of recombinases.

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ABO Blood Groups Influence Macrophage-mediated Phagocytosis of Plasmodium falciparum-infected Erythrocytes

October 16, 2012 - 06:58 -- Kabogo Ndegwa
Author(s): 
Kayla T. Wolofsky, Kodjo Ayi, Donald R. Branch, Annika K. Hult, Martin L. Olsson, W. Conrad Liles, Christine M. Cserti-Gazdewich, Kevin C. Kain
Reference: 
PLoS Pathog 8(10): e1002942

MalariaWorldErythrocyte polymorphisms associated with a survival advantage to Plasmodium falciparum infection have undergone positive selection.

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Reconsideration of Anopheles rivulorum as a vector of Plasmodium falciparum in Western Kenya: some evidence from biting time, blood preference, sporozoite positive rate, and pyrethroid resistance

October 12, 2012 - 16:40 -- Patrick Sampao
Author(s): 
Kawada H, Dida GO, Sonye G, Njenga SM, Mwandawiro C, Minakawa N
Reference: 
Parasites & Vectors 2012, 5:230 (10 October 2012)

MalariaWorldGiven the tendency for An. rivulorum to be active early in the evening, the presence of P. falciparum in the species, and the potential for the development of pyrethroid resistance, we strongly advocate reconsideration of the latent ability of this species as an epidemiologically important malaria vector.

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Opsonization of malaria-infected erythrocytes activates the inflammasome and enhances inflammatory cytokine secretion by human macrophages

October 11, 2012 - 07:02 -- Kabogo Ndegwa
Author(s): 
Zhou J, Ludlow LE, Hasang W, Rogerson SJ, Jaworowski A
Reference: 
Malaria Journal 2012, 11:343 (9 October 2012)

MalariaWorldIt is concluded that IL-6 secretion from MDM in response to CS2 IE does not require phagocytosis, whereas secretion of TNF and IL-1beta is dependent on Fcgamma receptor-mediated phagocytosis; for IL-1beta, this occurs by activation of the inflammasome.

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