NOT Open Access | Pathogenesis of malaria revisited
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Medical Microbiology and Immunology, Volume 201, Number 4 (2012), 599-604
Plasmodium falciparum malaria claims 1 million lives around the globe every year.
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Plasmodium falciparum
NOT Open Access | Malaria and human red blood cells
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Medical Microbiology and Immunology, Volume 201, Number 4 (2012), 593-598
Invasion by the malaria parasite, Plasmodium falciparum, brings about extensive changes in the host red cells.
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Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target
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PNAS October 16, 2012 vol. 109 no. 42 16823-16828
Malarial dihydrofolate reductase (DHFR) is the target of antifolate antimalarial drugs such as pyrimethamine and cycloguanil, the clinical efficacy of which have been compromised by resistance arising through mutations at various sites on the enzyme.
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Not Open Access |Genomic Sequencing of Plasmodium falciparum Malaria Parasites from Senegal Reveals the Demographic History of the Population
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Mol Biol Evol (2012) 29 (11): 3427-3439.
We show that there is no significant population structure among these Senegal sampling sites. By fitting demographic models to the synonymous allele-frequency spectrum, we also estimated a major 60-fold population expansion of this parasite population ∼20,000–40,000 years ago.
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SNP Genotyping Identifies New Signatures of Selection in a Deep Sample of West African Plasmodium falciparum Malaria Parasites
Reference:
Molecular Biology and Evolution, Volume 29, Issue 11 Pp. 3249-3253.
We discuss the value of deep population-specific genomic analyses for identifying selection signals within sampled endemic populations of parasites, which may correspond to local selection pressures such as distinctive therapeutic regimes or mosquito vectors.
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Feature Article: Evidence for additive and interaction effects of host genotype and infection in malaria
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PNAS October 16, 2012 vol. 109 no. 42 16786-16793
The host mechanisms responsible for protection against malaria remain poorly understood, with only a few protective genetic effects mapped in humans.
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NOT Open Access | In Vitro Activity of Fluorescent Dyes against Asexual Blood Stages of Plasmodium falciparum
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Antimicrob. Agents Chemother. November 2012 vol. 56 no. 11 5982-5985
Many successful antimicrobial drugs originate from synthetic dyes.
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Cell Biological Characterization of the Malaria Vaccine Candidate Trophozoite Exported Protein 1
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PLoS ONE 7(10): e46112
In a genome-wide screen for alpha-helical coiled coil motifs aiming at structurally defined vaccine candidates we identified PFF0165c.
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Initial Characterization of the Pf-Int Recombinase from the Malaria Parasite Plasmodium falciparum
Reference:
PLoS ONE 7(10): e46507
Our data identify for the first time a malaria parasite gene with structural and functional features of recombinases.
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ABO Blood Groups Influence Macrophage-mediated Phagocytosis of Plasmodium falciparum-infected Erythrocytes
Reference:
PLoS Pathog 8(10): e1002942
Erythrocyte polymorphisms associated with a survival advantage to Plasmodium falciparum infection have undergone positive selection.
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