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Plasmodium falciparum

Plasmodium falciparum genotype and gametocyte prevalence in children with uncomplicated malaria in coastal Ghana

December 14, 2016 - 17:30 -- Open Access
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Author(s): 
Ruth Ayanful-Torgby, Akua Oppong, Joana Abankwa, Festus Acquah, Kimberly C. Williamson and Linda Eva Amoah
Reference: 
Malaria Journal 2016 15:592, 9 December 2016

Although below detection by microscopy, gametocyte prevalence at submicroscopic levels are high in this region and emphasize the need for more effective elimination approaches like the development of transmission-blocking vaccines and safer gametocytocidal drugs.

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NOT Open Access | Design, synthesis and antimalarial evaluation of novel thiazole derivatives

August 8, 2016 - 10:06 -- NOT Open Access
Author(s): 
José María Bueno, Miguel Carda, Benigno Crespo, Ana Carmen Cuñat, Cristina de Cozar, María Luisa León, J. Alberto Marco, Nuria Roda, Juan F. Sanz-Cervera
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 26, Issue 16, 15 August 2016, Pages 3938–3944

As part of our medicinal chemistry program’s ongoing search for compounds with antimalarial activity, we prepared a series of thiazole analogs and conducted a SAR study analyzing their in vitro activities against the chloroquine-sensitive Plasmodium falciparum 3D7 strain.

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Generation of Plasmodium falciparum parasite-inhibitory antibodies by immunization with recombinantly-expressed CyRPA

March 16, 2016 - 17:42 -- Open Access
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Author(s): 
Paola Favuzza, Simon Blaser, Anita M. Dreyer, Guy Riccio, Marco Tamborrini, Ralf Thoma, Hugues Matile and Gerd Pluschke
Reference: 
Malaria Journal 2016 15:161, 15 March 2016

Recombinantly expressed PfCyRPA tested as adjuvanted vaccine formulations in mice elicited antibodies that significantly inhibit P. falciparum asexual blood stage parasite growth both in vitro and in vivo.

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Lack of effect of intermittent preventive treatment for malaria in pregnancy and intense drug resistance in western Uganda

September 30, 2015 - 16:48 -- Open Access
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Author(s): 
Vera Braun, Eva Rempis, Frank Mockenhaupt, et al.
Reference: 
Malaria Journal 2015, 14:372 (26 September 2015)

In Fort Portal, Uganda, reported use of IPTp with SP does not provide an observable benefit. The molecular markers of P. falciparum indicate high grade SP resistance reaching the threshold set by WHO for the discontinuation of IPTp with SP.

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Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®)

April 20, 2015 - 17:26 -- Open Access
Author(s): 
Alfred B Tiono, Halidou Tinto, Kamal Hamed, et al.
Reference: 
Malaria Journal 2015, 14:157 (15 April 2015)

A three-day regimen of AL dispersible formulation was efficacious and generally well tolerated in infants weighing <5 kg with uncomplicated P. falciparum malaria, but artemether and dihydroartemisinin exposures could not be supported by the preclinical safety margins for neurotoxicity.

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G6PD gene variants and its association with malaria in a Sri Lankan population

March 2, 2015 - 18:53 -- Open Access
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Author(s): 
Rajika L Dewasurendra, Kirk A Rockett, S Fernando, Richard Carter, Dominic P Kwiatkowski, Nadira D Karunaweera, in collaboration with the MalariaGEN Consortium
Reference: 
Malaria Journal 2015, 14:93 (22 February 2015)

This is the most detailed survey of G6PD SNPs in a Sri Lankan population undertaken so far that enabled novel description of single nucleotide polymorphisms within the G6PD gene.

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Not Open Access | Marked Decline in Malaria Prevalence among Pregnant Women and Their Offspring from 1996 to 2010 on the South Kenyan Coast

December 11, 2013 - 17:49 -- NOT Open Access
Author(s): 
Benjamin C. Kalayjian, Indu Malhotra, Peter Mungai, Penny Holding and Christopher L. King
Reference: 
Am J Trop Med Hyg 2013 89:1129-1134

These results show a profound reduction in malaria transmission in coastal Kenya.

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Not Open Access | Monitoring Malaria Vector Control Interventions: Effectiveness of Five Different Adult Mosquito Sampling Methods

September 13, 2013 - 18:23 -- NOT Open Access
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Author(s): 
Shirley A. Onyango , Uriel Kitron , Peter Mungai , Eric M. Muchiri , Elizabeth Kokwaro , Charles H. King , and Francis M. Mutuku
Reference: 
Journal of Medical Entomology 50(5):1140-1151. 2013
MalariaWorld

The objective of our study was to identify the most efficient mosquito sampling tool(s) for routine vector surveillance for malaria and lymphatic filariasis transmission in coastal Kenya.

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A longitudinal study on anaemia in children with Plasmodium falciparum infection in the Mount Cameroon region: prevalence, risk factors and perceptions by caregivers

March 6, 2013 - 16:16 -- Open Access
Author(s): 
Sumbele IU, Samje M, Nkuo-Akenji T
Reference: 
BMC Infectious Diseases 2013, 13:123 (5 March 2013)
MalariaWorld

A longitudinal study was conducted among 351 Plasmodium falciparum positive children to determine the prevalence, risk factors and the perception of anaemia by the caregivers in a semi-rural community. The investigative methods included the use of a structured questionnaire, clinical evaluation and laboratory investigations.

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Plasmodium falciparum Malaria Elicits Inflammatory Responses that Dysregulate Placental Amino Acid Transport

February 11, 2013 - 18:03 -- Open Access
Author(s): 
Philippe Boeuf, Elizabeth H. Aitken, Upeksha Chandrasiri, Caroline Lin Lin Chua, Bernie McInerney, Leon McQuade, Michael Duffy, Malcolm Molyneux, Graham Brown, Jocelyn Glazier, Stephen J. Rogerson
Reference: 
PLoS Pathog 9(2): e1003153
MalariaWorld

Overall, our data suggest that the fetoplacental unit responds to PM by altering its placental amino acid transport to maintain adequate fetal growth. However, IV more profoundly compromises placental amino acid transport function, leading to FGR. Our study offers the first pathogenetic explanation for FGR in PM.

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