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Plasmodium falciparum

Simulation of malaria epidemiology and control in the highlands of western Kenya

November 11, 2012 - 11:31 -- Open Access
Author(s): 
Stuckey EM, Stevenson JC, Cooke MK, Owaga C, Marube E, Oando G, Hardy D, Drakeley C, Smith TA, Cox J, Chitnis N
Reference: 
Malaria Journal 2012, 11:357 (29 October 2012)
MalariaWorld

The OpenMalaria model of P. falciparum transmission can be used to simulate the impact of different combinations of current and potential control interventions to help plan malaria control in this low transmission setting.

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In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam

November 11, 2012 - 10:28 -- Open Access
Author(s): 
Hien TT, Thuy-Nhien NT, Wolbers M, et al.
Reference: 
Malaria Journal 2012, 11:355 (26 October 2012)
MalariaWorld

This study demonstrated faster P. falciparum parasite clearance in southern Vietnam than in western Cambodia but slower clearance in comparison with historical data from Vietnam

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The Dynamics of Naturally Acquired Immunity to Plasmodium falciparum Infection

November 11, 2012 - 09:55 -- Open Access
Author(s): 
Mykola Pinkevych, Janka Petravic, Kiprotich Chelimo, James W. Kazura, Ann M. Moormann, Miles P. Davenport
Reference: 
PLoS Comput Biol 8(10): e1002729
MalariaWorld

Severe malaria occurs predominantly in young children and immunity to clinical disease is associated with cumulative exposure in holoendemic settings

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Plasmodium falciparum Gametocyte Development 1 (Pfgdv1) and Gametocytogenesis Early Gene Identification and Commitment to Sexual Development

November 11, 2012 - 09:49 -- Open Access
Author(s): 
Saliha Eksi, Belinda J. Morahan, Kim C. Williamson, et al.
Reference: 
PLoS Pathog 8(10): e1002964
MalariaWorld

Malaria transmission requires the production of male and female gametocytes in the human host followed by fertilization and sporogonic development in the mosquito midgut.

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Review: Shape-shifting gametocytes: how and why does P. falciparum go banana-shaped?

October 24, 2012 - 16:16 -- Open Access
Author(s): 
Matthew W.A. Dixon, Megan K. Dearnley, Eric Hanssen, Tim Gilberger, Leann Tilley
Reference: 
Trends in Parasitology, Volume 28, Issue 11, November 2012, Pages 471-478

MalariaWorldWe describe the machinery that elongates falciparum gametocytes and discuss its relation with the machinery that elongates the invasive zoites. We address the question – why do falciparum malaria gametocytes go banana-shaped? 

Intervention Review: Primaquine for reducing Plasmodium falciparum transmission

October 24, 2012 - 15:51 -- Patrick Sampao
Author(s): 
Patricia M Graves, Hellen Gelband, Paul Garner
Reference: 
Cochrane Database of Systematic Reviews 2012, Issue 9. Art. No.: CD008152

MalariaWorldTwo authors (PMG and HG) independently screened all abstracts, applied inclusion criteria, and abstracted data. We sought data on the effect of PQ on malaria transmission intensity, participant infectiousness, the number of participants with gametocytes, and gametocyte density over time. 

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Quinine localizes to a non-acidic compartment within the food vacuole of the malaria parasite Plasmodium falciparum

October 23, 2012 - 14:56 -- Patrick Sampao
Author(s): 
Bohórquez EB, Chua M, Meshnick SR
Reference: 
Malaria Journal 2012, 11:350 (22 October 2012)

MalariaWorldFluorescence microscopy was used to evaluate the subcellular localization of quinine in parasites containing different pfmdr1 copy numbers to determine if copy number of the gene affects drug localization.

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Review: Placing the Plasmodium falciparum epigenome on the map

October 23, 2012 - 11:10 -- Patrick Sampao
Author(s): 
Wieteke A.M. Hoeijmakers, Hendrik G. Stunnenberg, Richárd Bártfai
Reference: 
Trends in Parasitology, Volume 28, Issue 11, November 2012, Pages 486-495

MalariaWorldFurthermore, we highlight key questions to be answered, and provide a glimpse of developments required to gain true mechanistic understanding and to lift this maturing field to the next level.

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Review: Experimentally induced blood stage malaria infection as a tool for clinical research

October 23, 2012 - 10:47 -- Patrick Sampao
Author(s): 
Christian R. Engwerda, Gabriela Minigo, Fiona H. Amante, James S. McCarthy
Reference: 
Trends in Parasitology, Volume 28, Issue 11, November 2012, Pages 515-521

MalariaWorldWe will discuss the advantages and disadvantages of IBSM, and finish by describing some exciting new areas of research that have been made possible by this system.

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