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Plasmodium falciparum

Steered molecular dynamics simulations reveal critical residues for (un)binding of substrates, inhibitors and a product to the malarial M1 aminopeptidase

November 7, 2018 - 14:38 -- Open Access
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Author(s): 
Daniel S. Moore, Conor Brines, Heather Jewhurst, John P. Dalton, Irina G. Tikhonova
Reference: 
PLoS Comput Biol 14(10): e1006525

Malaria is a life-threatening disease spread by mosquitoes.

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“Wherever doctors cannot reach, the sunshine can”: overcoming potential barriers to malaria elimination interventions in Haiti

October 31, 2018 - 15:32 -- Open Access
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Author(s): 
Thomas Druetz, Katherine Andrinopoulos, Louis-Marie Boulos, Michaelle Boulos, Gregory S. Noland, Luccene Desir, Jean Frantz Lemoine and Thomas P. Eisele
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Malaria Journal 2018 17:393, 29 October 2018

There are several potential barriers and opportunities to implement community-based malaria elimination interventions in rural Haiti.

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Chloroquine resistance is associated to multi-copy pvcrt-o gene in Plasmodium vivax malaria in the Brazilian Amazon

July 17, 2018 - 15:59 -- Open Access
Author(s): 
Siuhelem Rocha Silva, Anne Cristine Gomes Almeida, Gisely Cardoso de Melo, et al.
Reference: 
Malaria Journal 2018 17:267, 16 July 2018

This was the first study with 42-day clinical follow-up to evaluate the variation of the number of copies and polymorphisms in the promoter region of the pvcrt-o and pvmdr1 genes in relation to treatment outcomes.

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A 17-year trend analysis of malaria at Adi Arkay, north Gondar zone, Northwest Ethiopia

April 10, 2018 - 15:44 -- Open Access
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Author(s): 
Habtie Tesfa, Abebe Genetu Bayih and Ayalew Jejaw Zeleke
Reference: 
Malaria Journal 2018 17:155, 6 April 2018

In relative terms, the overall positivity rate of malaria in the area over 17 years showed a significant reduction, but its magnitude as a public health problem is still alarming.

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Comparative Heterochromatin Profiling Reveals Conserved and Unique Epigenome Signatures Linked to Adaptation and Development of Malaria Parasites

March 21, 2018 - 14:48 -- Open Access
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Author(s): 
Sabine A. Fraschka, Michael Filarsky, Till S. Voss, et al.
Reference: 
Cell Host & Microbe, Volume 23, Issue 3, 14 March 2018, Pages 407-420.e8

Heterochromatin-dependent gene silencing is central to the adaptation and survival of Plasmodium falciparum malaria parasites, allowing clonally variant gene expression during blood infection in humans.

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Stabilization of RDT target antigens present in dried Plasmodium falciparum-infected samples for validating malaria rapid diagnostic tests at the point of care

January 9, 2018 - 16:13 -- Open Access
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Author(s): 
Collins Morang’a, Cyrus Ayieko, George Awinda, Rachel Achilla, Caroline Moseti, Bernhards Ogutu, John Waitumbi and Elizabeth Wanja
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Malaria Journal 2018 17:10, 8 January 2018

These findings confirm that stabilizing RDT target antigens in dried P. falciparum-infected samples using chemical additives provides field-stable positive controls for malaria RDTs.

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Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assays

August 8, 2017 - 11:19 -- Open Access
Author(s): 
Isaie J. Reuling, Will J. R. Stone, Robert W. Sauerwein, et al.
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Malaria Journal 2017 16:315, 5 August 2017

The current study demonstrates that concentration methods of P. falciparum gametocyte-infected whole blood samples can enhance transmission in mosquito-feeding assays.

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Ex vivo susceptibility and genotyping of Plasmodium falciparum isolates from Pikine, Senegal

June 15, 2017 - 15:27 -- Open Access
Author(s): 
Aminata Mbaye, Amy Gaye, Daouda Ndiaye, et al.
Reference: 
Malaria Journal 2017 16:250, 14 June 2017

An increase in sensitivity of isolates to chloroquine was observed.

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Molecular markers of anti-malarial drug resistance in Central, West and East African children with severe malaria

May 25, 2017 - 08:49 -- Open Access
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Author(s): 
Christian N. Nguetse, Ayola Akim Adegnika, Tsiri Agbenyega, Bernhards R. Ogutu, Sanjeev Krishna, Peter G. Kremsner and Thirumalaisamy P. Velavan
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Malaria Journal 2017 16:217, 23 May 2017

Artemisinins are still highly efficacious in large malaria-endemic regions though declining efficacy has occurred in Southeast Asia.

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Effects of Plasmodium falciparum infection on umbilical artery resistance and intrafetal blood flow distribution: a Doppler ultrasound study from Papua New Guinea

January 24, 2017 - 18:02 -- Open Access
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Author(s): 
Maria Ome-Kaius, Stephan Karl, Regina Alice Wangnapi, John Walpe Bolnga, Glen Mola, Jane Walker, Ivo Mueller, Holger Werner Unger and Stephen John Rogerson
Reference: 
Malaria Journal 2017 16:35, 19 January 2017

Both microscopic and sub-microscopic P. falciparum infections impair fetoplacental and intrafetal flow, at least temporarily.

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