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Plasmodium falciparum

Not Open Access | Marked Decline in Malaria Prevalence among Pregnant Women and Their Offspring from 1996 to 2010 on the South Kenyan Coast

December 11, 2013 - 17:49 -- NOT Open Access
Author(s): 
Benjamin C. Kalayjian, Indu Malhotra, Peter Mungai, Penny Holding and Christopher L. King
Reference: 
Am J Trop Med Hyg 2013 89:1129-1134

These results show a profound reduction in malaria transmission in coastal Kenya.

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Not Open Access | Monitoring Malaria Vector Control Interventions: Effectiveness of Five Different Adult Mosquito Sampling Methods

September 13, 2013 - 18:23 -- NOT Open Access
Tags: 
Author(s): 
Shirley A. Onyango , Uriel Kitron , Peter Mungai , Eric M. Muchiri , Elizabeth Kokwaro , Charles H. King , and Francis M. Mutuku
Reference: 
Journal of Medical Entomology 50(5):1140-1151. 2013
MalariaWorld

The objective of our study was to identify the most efficient mosquito sampling tool(s) for routine vector surveillance for malaria and lymphatic filariasis transmission in coastal Kenya.

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A longitudinal study on anaemia in children with Plasmodium falciparum infection in the Mount Cameroon region: prevalence, risk factors and perceptions by caregivers

March 6, 2013 - 16:16 -- Open Access
Author(s): 
Sumbele IU, Samje M, Nkuo-Akenji T
Reference: 
BMC Infectious Diseases 2013, 13:123 (5 March 2013)
MalariaWorld

A longitudinal study was conducted among 351 Plasmodium falciparum positive children to determine the prevalence, risk factors and the perception of anaemia by the caregivers in a semi-rural community. The investigative methods included the use of a structured questionnaire, clinical evaluation and laboratory investigations.

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Plasmodium falciparum Malaria Elicits Inflammatory Responses that Dysregulate Placental Amino Acid Transport

February 11, 2013 - 18:03 -- Open Access
Author(s): 
Philippe Boeuf, Elizabeth H. Aitken, Upeksha Chandrasiri, Caroline Lin Lin Chua, Bernie McInerney, Leon McQuade, Michael Duffy, Malcolm Molyneux, Graham Brown, Jocelyn Glazier, Stephen J. Rogerson
Reference: 
PLoS Pathog 9(2): e1003153
MalariaWorld

Overall, our data suggest that the fetoplacental unit responds to PM by altering its placental amino acid transport to maintain adequate fetal growth. However, IV more profoundly compromises placental amino acid transport function, leading to FGR. Our study offers the first pathogenetic explanation for FGR in PM.

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Artesunate-amodiaquine efficacy in Congolese children with acute uncomplicated falciparum malaria in Brazzaville

February 11, 2013 - 16:29 -- Open Access
Author(s): 
Ndounga M, Mayengue P, Casimiro P, Loumouamou D, Basco LK, Ntoumi F, Brasseur P
Reference: 
Malaria Journal 2013, 12:53 (5 February 2013)
MalariaWorld

This study has shown the high efficacy of AS + AQ in Congolese patients of all ages with acute uncomplicated falciparum malaria and serves as the baseline efficacy and tolerance of this ACT in Brazzaville.

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Not Open Access | Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold

November 25, 2012 - 14:20 -- NOT Open Access
Author(s): 
Vanida Choomuenwai, Katherine T. Andrews, Rohan A. Davis
Reference: 
Bioorganic & Medicinal Chemistry, Volume 20, Issue 24, 15 December 2012, Pages 7167-7174
MalariaWorld

This compound displayed moderate cytotoxicity against neonatal foreskin fibroblast (NFF) cells with an IC50 of 15.6 μM.

Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo

November 25, 2012 - 14:02 -- Open Access
Author(s): 
Kamkumo RG, Ngoutane AM, Tchokouaha LR, Fokou PV, Madiesse EA, Legac J, Kezetas JJ, Lenta BN, Boyom FF, Dimo T, Mbacham WF, Gut J, Rosenthal PJ
Reference: 
Malaria Journal 2012, 11:382 (21 November 2012)
MalariaWorld

This paper describes the results of an anti-malarial activity-driven investigation of the fruits of this Cameroonian plant.

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Not Open Access | First-Trimester Plasmodium falciparum Infections Display a Typical “Placental” Phenotype

November 21, 2012 - 16:52 -- NOT Open Access
Author(s): 
Justin Doritchamou, Gwladys Bertin, Azizath Moussiliou, Pascal Bigey, Firmine Viwami, Sem Ezinmegnon, Nadine Fievet, Achille Massougbodji, Philippe Deloron, and Nicaise Tuikue Ndam
Reference: 
J Infect Dis. (2012) 206 (12): 1911-1919.
MalariaWorld

 

Here, we investigated the transcription pattern of var genes by real-time polymerase chain reaction, the expression of VAR2CSA, protein by flow cytometry, and the CSA-binding ability of IEs collected at different stages of pregnancy using a static-based Petri dish assay.

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Not Open Access | Analysis of immunogenicity of different protein groups from malaria parasite Plasmodium falciparum

November 12, 2012 - 15:14 -- NOT Open Access
Author(s): 
KatarzynaKrzyczmonik, MichałŚwitnicki, SzymonKaczanowski
Reference: 
Infection, Genetics and Evolution, Volume 12, Issue 8, December 2012, Pages 1911-1916
MalariaWorld

We confirmed the expectations that proteins containing IEDB epitopes are subject to stronger diversifying selection which is evidenced by higher pN/pS ratio. A stage characterized by the highest average pN/pS ratio is that of the sporozoite.

Evaluation of the malaria rapid diagnostic test SDFK90: detection of both PfHRP2 and Pf-pLDH

November 11, 2012 - 11:50 -- Open Access
Author(s): 
Heutmekers M, Gillet P, Cnops L, Bottieau E, Van Esbroeck M, Maltha J, Jacobs J
Reference: 
Malaria Journal 2012, 11:359 (29 October 2012)
MalariaWorld

The combination of PfHRP2 and Pf-pLDH ensures a low detection threshold and counters potential problems of PfHRP2 detection such as gene deletions and the prozone effect.

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