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Plasmodium falciparum

Review: Low Complexity Regions behave as tRNA sponges to help co-translational folding of plasmodial proteins

December 17, 2009 - 13:29 -- Patrick Sampao
Author(s): 
Magali Frugier, Tania Bour, Maya Ayach, Manuel A.S. Santos, Joëlle Rudinger-Thirion, Anne Théobald-Dietrich, Elizabetta Pizzi
Reference: 
FEBS Letters, Volume 584, Issue 2, 21 January 2010, Pages 448-454

In our model, the abundant Low Complexity Regions present in Plasmodium proteins replace the codon preferences, which influence the assembly of protein secondary structures.

Review: Diversity and similarity in the tRNA world: Overall view and case study on malaria-related tRNAs

December 17, 2009 - 13:24 -- Patrick Sampao
Author(s): 
Joern Pütza, Richard Giegéa and Catherine Florentz
Reference: 
FEBS Letters, Volume 584, Issue 2, 21 January 2010, Pages 350-358

Transfer RNAs (tRNAs) are ancient macromolecules that have evolved under various environmental pressures as adaptors in translation in all forms of life but also towards alternative structures and functions. The present knowledge on both “canonical” and “deviating” signature motifs retrieved from vertical and horizontal sequence comparisons is briefly reviewed.

Plasmodium falciparum culture: The benefits of shaking

December 16, 2009 - 08:03 -- Kabogo Ndegwa
Author(s): 
Richard J.W. Allen, Kiaran Kirk
Reference: 
Molecular and Biochemical Parasitology, Volume 169, Issue 1, January 2010, Pages 63-65, doi:10.1016/j.molbiopara.2009.09.005

Here, extending previous work, we have quantified the favourable effects of continuous agitation on three indices of culture growth

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Open Access | Plasmodium falciparum Infection Significantly Impairs Placental Cytokine Profile in HIV Infected Cameroonian Women

December 15, 2009 - 21:00 -- Ingeborg van Schayk
Author(s): 
Kfutwah A, Mary JY, Lemen B, Leke R, Rousset D, et al.
Reference: 
PLoS ONE 4(12): e8114

These results show that P. falciparum infection profoundly modifies the placenta cytokine environment and acts as a confounding factor, masking the impact of HIV-1 in co-infected women.

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Open Access | The use of mobile phone data for the estimation of the travel patterns and imported Plasmodium falciparum rates among Zanzibar residents

December 14, 2009 - 11:57 -- Ingeborg van Schayk
Author(s): 
Andrew J Tatem, Youliang Qiu, David L Smith, Oliver Sabot, Abdullah S Ali, Bruno Moonen
Reference: 
Malaria Journal 2009, 8:287 (10 December 2009)

In combination with spatial data on malaria endemicity and transmission models, movement patterns derived from phone records can inform on the likely sources and rates of malaria importation.

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Novel Putative Glycosylphosphatidylinositol-Anchored Micronemal Antigen of Plasmodium falciparum That Binds to Erythrocytes

December 13, 2009 - 10:40 -- Ingeborg van Schayk
Author(s): 
Louise Hinds, Judith L. Green, Ellen Knuepfer, Munira Grainger, and Anthony A. Holder
Reference: 
Eukaryotic Cell 2009;8 1869-1879

We have identified a new Plasmodium falciparum erythrocyte binding protein that appears to be located in the micronemes of the merozoite stage of the parasite and membrane linked through a glycosylphosphatidylinositol (GPI) anchor.

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Open Access | Impact of RTS,S/AS02A and RTS,S/AS01B on Genotypes of P. falciparum in Adults Participating in a Malaria Vaccine Clinical Trial

December 11, 2009 - 12:50 -- Ingeborg van Schayk
Tags: 
Author(s): 
Waitumbi JN, Anyona SB, Hunja CW, Kifude CM, Polhemus ME, et al.
Reference: 
PLoS ONE 4(11): e7849

The distribution of csp sequences and the MOI of the infecting strains were examined at baseline and in break-through infections from vaccinated individuals and from those receiving a non-malarial vaccine.

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Open Access | Plasmodium falciparum: hrp3 promoter region is associated with stage-specificity and episomal recombination

December 8, 2009 - 12:47 -- Ingeborg van Schayk
Author(s): 
López-Estraño C, Semblat JP, Gopalakrishnan AM, Turner L, Mazier D, Haldar K.
Reference: 
Exp Parasitol. 2007 Jul;116(3):327-33

Our results describe a ring-stage specific regulatory region possibly involved in episomal promoter recombination, suggesting that common sequences might mediate both processes.

Open Access | An enhancer-like region regulates hrp3 promoter stage-specific gene expression in the human malaria parasite Plasmodium falciparum

December 8, 2009 - 12:39 -- Ingeborg van Schayk
Author(s): 
López-Estraño C, Gopalakrishnan AM, Semblat JP, Fergus MR, Mazier D, Haldar K.
Reference: 
Biochim Biophys Acta. 2007 Jul-Aug;1769(7-8):506-13

The data presented in this study demonstrates that stage specific promoter activity of the hrp3 gene in P. falciparum blood stage parasites is supported, at least in-part, by a small promoter region that can function in the absence of a larger chromosomal context.

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In Vitro Activities of Piperaquine, Lumefantrine, and Dihydroartemisinin in Kenyan Plasmodium falciparum Isolates and Polymorphisms in pfcrt and pfmdr1

December 7, 2009 - 12:03 -- Ingeborg van Schayk
Author(s): 
Leah Mwai, Steven M. Kiara, Abdi Abdirahman, Lewa Pole, Anja Rippert, Abdi Diriye, Pete Bull, Kevin Marsh, Steffen Borrmann, and Alexis Nzila
Reference: 
Antimicrob. Agents Chemother. 2009;53 5069-5073

We have analyzed the in vitro chemosensitivity profiles of 115 Kenyan isolates for chloroquine (CQ), piperaquine, lumefantrine (LM), and dihydroartemisinin in association with polymorphisms in pfcrt at codon 76 and pfmdr1 at codon 86, as well as with variations of the copy number of pfmdr1.

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