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Plasmodium falciparum

Timing of malaria messages for target audience on radio airwaves

August 22, 2012 - 13:49 -- Kabogo Ndegwa
Author(s): 
Batwala V, Magnussen P, Mirembe J, Mulogo E, Nuwaha F
Reference: 
Malaria Journal 2012, 11:283 (20 August 2012)

MalariaWorldPlanners of malaria radio interventions need to broadcast their messages within the two peak EAT of 12.00-14.00 and 18.00-23.00.

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Development, validation and evaluation of a rapid PCR-nucleic acid lateral flow immuno-assay for the detection of Plasmodium and the differentiation between Plasmodium falciparum and Plasmodium vivax

August 22, 2012 - 06:57 -- Kabogo Ndegwa
Author(s): 
Mens PF, Moers AP, de Bes LM, Flint J, Sak JR, Keereecharoen L, van Overmeir C, Verweij JJ, Hallett RL, Wihokhoen B, Proux S, Schallig HD, van Amerongen A
Reference: 
Malaria Journal 2012, 11:279 (17 August 2012)

MalariaWorldPCR-NALFIA is a sensitive, specific and robust assay able to identify Plasmodium species with good accuracy.

Autophagy-Related Atg8 Localizes to the Apicoplast of the Human Malaria Parasite Plasmodium falciparum

August 22, 2012 - 06:52 -- Kabogo Ndegwa
Author(s): 
Kei Kitamura, Chieko Kishi-Itakura, Takafumi Tsuboi, Shigeharu Sato, Kiyoshi Kita, Nobuo Ohta, Noboru Mizushima
Reference: 
PLoS ONE 7(8): e42977

MalariaWorldAutophagy is a membrane-mediated degradation process, which is governed by sequential functions of Atg proteins.

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Therapeutic efficacy of artesunate in the treatment of uncomplicated Plasmodium falciparum malaria and anti-malarial, drug-resistance marker polymorphisms in populations near the China- Myanmar border

August 22, 2012 - 06:40 -- Kabogo Ndegwa
Author(s): 
Huang F, Tang L, Yang H, Zhou S, Sun X, Liu H
Reference: 
Malaria Journal 2012, 11:278 (16 August 2012)

MalariaWorldPlasmodium falciparum infection was associated with slow parasite clearance and suspected artemisinin resistance at the China-Myanmar border area.

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Not Open Access | Translocation of Sickle Cell Erythrocyte MicroRNAs into Plasmodium falciparum Inhibits Parasite Translation and Contributes to Malaria Resistance

August 20, 2012 - 11:06 -- Patrick Sampao
Author(s): 
Gregory LaMonte, Nisha Philip, Jen-Tsan Chi, et al.
Reference: 
Cell Host & Microbe, Volume 12, Issue 2, 16 August 2012, Pages 187-199

MalariaWorldHere we show that the dysregulated microRNA (miRNA) composition, of either heterozygous HbAS or homozygous HbSS erythrocytes, contributes to resistance against P. falciparum.

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NOT Open Access | Synthesis and in vitro evaluation of new chloroquine-chalcone hybrids against chloroquine-resistant strain of Plasmodium falciparum

August 16, 2012 - 08:18 -- Kabogo Ndegwa
Author(s): 
Koneni V. Sashidhara, Srinivasa Rao Avula, Gopala Reddy Palnati, Shiv Vardan Singh, Kumkum Srivastava, Sunil K. Puri, J.K. Saxena
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 22, Issue 17, 1 September 2012, Pages 5455–5459

MalariaWorldThe control of malaria has been complicated with increasing resistance of malarial parasite against existing antimalarials.

NOT Open Access | P005 Cellular responses to repeated malaria episodes: Does the concept of original antigenic sin apply to Plasmodium falciparum malaria?

August 16, 2012 - 08:15 -- Kabogo Ndegwa
Author(s): 
B. Seyoum Alemu, A. Famanta, S. Doumbia, S. Samake, B. Traore, J. Duan, I. Zaidi, R.M. Fairhurst, C.A. Long, P.E. Duffy, M. Diakite, M. Walther
Reference: 
Cytokine, Volume 59, Issue 3, September 2012, Pages 520

MalariaWorldThe results of this study will enable us to determine whether original antigenic sin influences malaria incidence, and may reveal an association between a specific immunological response pattern and enhanced protection from a subsequent malaria episode, which can be further explored in identifying candidate vaccine antigens.

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Not Open Access | Electroporation-mediated genetic vaccination for antigen mapping: Application to Plasmodium falciparum VAR2CSA protein

August 15, 2012 - 13:01 -- Patrick Sampao
Author(s): 
Bita Bordbar, Sédami Gnidehou, Nicaise Tuikue Ndam, Justin Doritchamou, Azizath Moussiliou, Mickael Quiviger, Philippe Deloron, Daniel Scherman, Pascal Bigey
Reference: 
Bioelectrochemistry, Volume 87, October 2012, Pages 132–137

MalariaWorldHere we describe the use of electroporation mediated DNA immunization to identify important protective epitopes from the large VAR2CSA protein from Plasmodium falciparum implicated in the pathology of placental malaria.

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Evaluation of dihydrofolate reductase and dihydropteroate synthetase genotypes that confer resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum in Haiti

August 15, 2012 - 09:44 -- Kabogo Ndegwa
Author(s): 
Carter TE, Warner M, Mulligan CJ, Existe A, Victor YS, Memnon G, Boncy J, Oscar R, Fukuda MM, Okech BA
Reference: 
Malaria Journal 2012, 11:275 (13 August 2012)

MalariaWorldMalaria caused by Plasmodium falciparum infects roughly 30,000 individuals in Haiti each year.

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A simple and inexpensive haemozoin-based colorimetric method to evaluate anti-malarial drug activity

August 15, 2012 - 08:14 -- Kabogo Ndegwa
Author(s): 
Men T, Huy N, Trang D, Shuaibu M, Hirayama K, Kamei K
Reference: 
Malaria Journal 2012, 11:272 (9 August 2012)

MalariaWorldThe haemozoin-based colorimetric assay can be considered as an alternative, simple, robust, inexpensive and convenient method, making it applicable in developing countries.

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