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Plasmodium falciparum

Stabilization of RDT target antigens present in dried Plasmodium falciparum-infected samples for validating malaria rapid diagnostic tests at the point of care

January 9, 2018 - 16:13 -- Open Access
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Author(s): 
Collins Morang’a, Cyrus Ayieko, George Awinda, Rachel Achilla, Caroline Moseti, Bernhards Ogutu, John Waitumbi and Elizabeth Wanja
Reference: 
Malaria Journal 2018 17:10, 8 January 2018

These findings confirm that stabilizing RDT target antigens in dried P. falciparum-infected samples using chemical additives provides field-stable positive controls for malaria RDTs.

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Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assays

August 8, 2017 - 11:19 -- Open Access
Author(s): 
Isaie J. Reuling, Will J. R. Stone, Robert W. Sauerwein, et al.
Reference: 
Malaria Journal 2017 16:315, 5 August 2017

The current study demonstrates that concentration methods of P. falciparum gametocyte-infected whole blood samples can enhance transmission in mosquito-feeding assays.

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Ex vivo susceptibility and genotyping of Plasmodium falciparum isolates from Pikine, Senegal

June 15, 2017 - 15:27 -- Open Access
Author(s): 
Aminata Mbaye, Amy Gaye, Daouda Ndiaye, et al.
Reference: 
Malaria Journal 2017 16:250, 14 June 2017

An increase in sensitivity of isolates to chloroquine was observed.

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Molecular markers of anti-malarial drug resistance in Central, West and East African children with severe malaria

May 25, 2017 - 08:49 -- Open Access
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Author(s): 
Christian N. Nguetse, Ayola Akim Adegnika, Tsiri Agbenyega, Bernhards R. Ogutu, Sanjeev Krishna, Peter G. Kremsner and Thirumalaisamy P. Velavan
Reference: 
Malaria Journal 2017 16:217, 23 May 2017

Artemisinins are still highly efficacious in large malaria-endemic regions though declining efficacy has occurred in Southeast Asia.

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Effects of Plasmodium falciparum infection on umbilical artery resistance and intrafetal blood flow distribution: a Doppler ultrasound study from Papua New Guinea

January 24, 2017 - 18:02 -- Open Access
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Author(s): 
Maria Ome-Kaius, Stephan Karl, Regina Alice Wangnapi, John Walpe Bolnga, Glen Mola, Jane Walker, Ivo Mueller, Holger Werner Unger and Stephen John Rogerson
Reference: 
Malaria Journal 2017 16:35, 19 January 2017

Both microscopic and sub-microscopic P. falciparum infections impair fetoplacental and intrafetal flow, at least temporarily.

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Plasmodium falciparum genotype and gametocyte prevalence in children with uncomplicated malaria in coastal Ghana

December 14, 2016 - 17:30 -- Open Access
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Author(s): 
Ruth Ayanful-Torgby, Akua Oppong, Joana Abankwa, Festus Acquah, Kimberly C. Williamson and Linda Eva Amoah
Reference: 
Malaria Journal 2016 15:592, 9 December 2016

Although below detection by microscopy, gametocyte prevalence at submicroscopic levels are high in this region and emphasize the need for more effective elimination approaches like the development of transmission-blocking vaccines and safer gametocytocidal drugs.

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NOT Open Access | Design, synthesis and antimalarial evaluation of novel thiazole derivatives

August 8, 2016 - 10:06 -- NOT Open Access
Author(s): 
José María Bueno, Miguel Carda, Benigno Crespo, Ana Carmen Cuñat, Cristina de Cozar, María Luisa León, J. Alberto Marco, Nuria Roda, Juan F. Sanz-Cervera
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 26, Issue 16, 15 August 2016, Pages 3938–3944

As part of our medicinal chemistry program’s ongoing search for compounds with antimalarial activity, we prepared a series of thiazole analogs and conducted a SAR study analyzing their in vitro activities against the chloroquine-sensitive Plasmodium falciparum 3D7 strain.

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Generation of Plasmodium falciparum parasite-inhibitory antibodies by immunization with recombinantly-expressed CyRPA

March 16, 2016 - 17:42 -- Open Access
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Author(s): 
Paola Favuzza, Simon Blaser, Anita M. Dreyer, Guy Riccio, Marco Tamborrini, Ralf Thoma, Hugues Matile and Gerd Pluschke
Reference: 
Malaria Journal 2016 15:161, 15 March 2016

Recombinantly expressed PfCyRPA tested as adjuvanted vaccine formulations in mice elicited antibodies that significantly inhibit P. falciparum asexual blood stage parasite growth both in vitro and in vivo.

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Lack of effect of intermittent preventive treatment for malaria in pregnancy and intense drug resistance in western Uganda

September 30, 2015 - 16:48 -- Open Access
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Author(s): 
Vera Braun, Eva Rempis, Frank Mockenhaupt, et al.
Reference: 
Malaria Journal 2015, 14:372 (26 September 2015)

In Fort Portal, Uganda, reported use of IPTp with SP does not provide an observable benefit. The molecular markers of P. falciparum indicate high grade SP resistance reaching the threshold set by WHO for the discontinuation of IPTp with SP.

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Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®)

April 20, 2015 - 17:26 -- Open Access
Author(s): 
Alfred B Tiono, Halidou Tinto, Kamal Hamed, et al.
Reference: 
Malaria Journal 2015, 14:157 (15 April 2015)

A three-day regimen of AL dispersible formulation was efficacious and generally well tolerated in infants weighing <5 kg with uncomplicated P. falciparum malaria, but artemether and dihydroartemisinin exposures could not be supported by the preclinical safety margins for neurotoxicity.

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