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Plasmodium falciparum

Detection of malaria parasites in dried human blood spots using mid-infrared spectroscopy and logistic regression analysis

October 8, 2019 - 15:00 -- Open Access
Author(s): 
Emmanuel P. Mwanga, Elihaika G. Minja, Fredros O. Okumu, et al.
Reference: 
Malaria Journal 2019 18:341, 7 October 2019

Epidemiological surveys of malaria currently rely on microscopy, polymerase chain reaction assays (PCR) or rapid diagnostic test kits for Plasmodium infections (RDTs). This study investigated whether mid-infrared (MIR) spectroscopy coupled with supervised machine learning could constitute an alternative method for rapid malaria screening, directly from dried human blood spots.

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Genetic polymorphism of the N-terminal region in circumsporozoite surface protein of Plasmodium falciparum field isolates from Sudan

October 7, 2019 - 15:17 -- Open Access
Author(s): 
Nouh S. Mohamed, Musab M. Ali Albsheer, Mohamed M. Elbasheir, et al.
Reference: 
Malaria Journal 2019 18:333, 1 October 2019

Malaria caused by Plasmodium falciparum parasite is still known to be one of the most significant public health problems in sub-Saharan Africa. Genetic diversity of the Sudanese P. falciparum based on the diversity in the circumsporozoite surface protein (PfCSP) has not been previously studied. Therefore, this study aimed to investigate the genetic diversity of the N-terminal region of the pfcsp gene.

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NOT Open Access | Plasmodium helical interspersed subtelomeric family—an enigmatic piece of the Plasmodium biology puzzle

October 1, 2019 - 14:35 -- NOT Open Access
Author(s): 
Vikash Kumar, Ankita Behl, Rachana Sharma, Aanchal Sharma & Rachna Hora
Reference: 
Parasitology Research, October 2019, Volume 118, Issue 10, pp 2753–2766

Plasmodium falciparum (Pf) refurbishes the infected erythrocytes by exporting a myriad of parasite proteins to the host cell.

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Evaluation of Plasmodium falciparum MSP10 and its development as a serological tool for the Peruvian Amazon region

September 30, 2019 - 13:28 -- Open Access
Author(s): 
Jorge Bendezu, Elizabeth Villasis, Katherine Torres, et al.
Reference: 
Malaria Journal 2019 18:327, 23 September 2019

Different antigens are needed to characterize Plasmodium falciparum infection in terms of seroreactivity and targets for invasion inhibition, in order to guide and identify the proper use of such proteins as tools for the development of serological markers and/or as vaccine candidates.

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Not Open Access | Molecular Surveillance of Drug Resistance of Plasmodium falciparum Isolates Imported from Angola in Henan Province, China

September 30, 2019 - 13:26 -- NOT Open Access
Author(s): 
Ruimin Zhou, Chengyun Yang, Suhua Li, Yuling Zhao, Ying Liu, Dan Qian, Hao Wang, Deling Lu, Hongwei Zhang and Fang Huang
Reference: 
Antimicrob. Agents Chemother. September 2019 63:e00552-19

Angola was the main origin country for the imported malaria in Henan Province, China.

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The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion

September 24, 2019 - 15:15 -- Open Access
Author(s): 
Emma S. Sherling, Abigail J. Perrin, Ellen Knuepfer, Matthew R. G. Russell, Lucy M. Collinson, Louis H. Miller, Michael J. Blackman
Reference: 
PLoS Pathog 15(9): e1008049

The malaria parasite Plasmodium falciparum invades, replicates within and destroys red blood cells in an asexual blood stage life cycle that is responsible for clinical disease and crucial for parasite propagation.

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Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features

September 24, 2019 - 15:06 -- Open Access
Author(s): 
David F. Read, Kate Cook, Yang Y. Lu, Karine G. Le Roch, William Stafford Noble
Reference: 
PLoS Comput Biol 15(9): e1007329

Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism’s complex life cycle.

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Rare mutations in Pfmdr1 gene of Plasmodium falciparum detected in clinical isolates from patients treated with anti-malarial drug in Nigeria

September 23, 2019 - 14:42 -- Open Access
Author(s): 
Abel O. Idowu, Wellington A. Oyibo, Sanjib Bhattacharyya, Manjeet Khubbar, Udoma E. Mendie, Violet V. Bumah, Carolyn Black, Joseph Igietseme and Anthony A. Azenabor
Reference: 
Malaria Journal 2019 18:319, 18 September 2019

Plasmodium falciparum, the deadliest causative agent of malaria, has high prevalence in Nigeria. Drug resistance causing failure of previously effective drugs has compromised anti-malarial treatment. On this basis, there is need for a proactive surveillance for resistance markers to the currently recommended artemisinin-based combination therapy (ACT), for early detection of resistance before it become widespread.

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Natural selection and genetic diversity of domain I of Plasmodium falciparum apical membrane antigen-1 on Bioko Island

September 23, 2019 - 14:34 -- Open Access
Author(s): 
Ya-Nan Wang, Min Lin, Hai-Bin Chen, et al.
Reference: 
Malaria Journal 2019 18:317, 18 September 2019

Plasmodium falciparum apical membrane antigen-1 (PfAMA-1) is a promising candidate antigen for a blood-stage malaria vaccine. However, antigenic variation and diversity of PfAMA-1 are still major problems to design a universal malaria vaccine based on this antigen, especially against domain I (DI). Detail understanding of the PfAMA-1 gene polymorphism can provide useful information on this potential vaccine component. Here, general characteristics of genetic structure and the effect of natural selection of DIs among Bioko P. falciparum isolates were analysed.

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Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection

September 23, 2019 - 14:05 -- Open Access
Author(s): 
Damian A. Oyong, Jessica R. Loughland, Michelle J. Boyle, et al.
Reference: 
Malaria Journal 2019 18:312, 18 September 2019

Anaemia is a major consequence of malaria, caused by the removal of both infected and uninfected red blood cells (RBCs) from the circulation. Complement activation and reduced expression of complement regulatory proteins (CRPs) on RBCs are an important pathogenic mechanism in severe malarial anaemia in both Plasmodium falciparum and Plasmodium vivax infection. However, little is known about loss of CRPs on RBCs during mild malarial anaemia and in low-density infection.

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