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Antimalarials

Measuring Coverage in MNCH: Accuracy of Measuring Diagnosis and Treatment of Childhood Malaria from Household Surveys in Zambia

May 9, 2013 - 09:49 -- Open Access
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Author(s): 
Thomas P. Eisele, Kafula Silumbe, Josh Yukich, Busiku Hamainza, Joseph Keating, Adam Bennett, John M. Miller
Reference: 
PLoS Med 10(5): e1001417
MalariaWorld

Based on these findings, results from household surveys should continue to be used for ascertaining the coverage of children with a fever in the past 2 wk that received an ACT.

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Not Open Access | Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials

June 29, 2012 - 13:38 -- Patrick Sampao
Author(s): 
Xianming Deng, Advait Nagle, Tao Wu, Nathanael S. Gray, et al.
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 14, 15 July 2010, Pages 4027-4031

MalariaWorldA systematic SAR study resulted in the identification of compound 40 which exhibits good potency against both wild-type and drug resistant parasites and exhibits good in vivo pharmacokinetic properties.

4-Aminoquinoline derived antimalarials: Synthesis, antiplasmodial activity and heme polymerization inhibition studies

October 13, 2010 - 10:22 -- Kabogo Ndegwa
Author(s): 
V.R. Solomon, W. Haq, M. Smilkstein, Kumkum Srivastava, Sunil K. Puri, S.B. Katti
Reference: 
European Journal of Medicinal Chemistry, Volume 45, Issue 11, November 2010, Pages 4990-4996

A new series of 4-aminoquinoline derivatives have been synthesized and found to be active against both susceptible and resistant strains of Plasmodium falciparum in vitro.

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Policy brief on improving access to artemisinin-based combination therapies for malaria in Mozambique

April 20, 2010 - 15:02 -- Patrick Sampao
Author(s): 
Francisco Mbofanaa , Gertrudes Machatinea and Celeste Moreiraa
Reference: 
International Journal of Technology Assessment in Health Care 26 : 250-254 2010

The Presidential Malaria Initiative (PMI) -supported Malaria Indicator Survey, conducted in 2007, found the national prevalence of malaria parasitemia among children 6 to 59 months old to be 38.5 percent, with a range by province from 60.4 percent in Nampula to less than 10 percent in Maputo.

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