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Plasmodium falciparum

Increasing trends of malaria in a border area of the Greater Mekong Subregion

September 13, 2019 - 07:01 -- Open Access
Author(s): 
Jinting Geng, Pallavi Malla, JLiwang Cui, et al.
Reference: 
Malaria Journal 2019 18:309, 12 September 2019

Intensive malaria transmission along international borders is a significant impediment to malaria elimination in the Greater Mekong Subregion (GMS) of Southeast Asia. Passive case detection (PCD) was used to study the dynamics and trends of malaria transmission at the China–Myanmar border to provide epidemiologic information for improved malaria control.

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Microscopic and submicroscopic Plasmodium falciparum infection, maternal anaemia and adverse pregnancy outcomes in Papua New Guinea: a cohort study

September 10, 2019 - 15:24 -- Open Access
Author(s): 
Holger W. Unger, Anna Rosanas-Urgell, Leanne J. Robinson, Maria Ome-Kaius, Shadrach Jally, Alexandra J. Umbers, Willie Pomat, Ivo Mueller, Eline Kattenberg and Stephen J. Rogerson
Reference: 
Malaria Journal 2019 18:302, 2 September 2019

Infection during pregnancy with Plasmodium falciparum is associated with maternal anaemia and adverse birth outcomes including low birth weight (LBW). Studies using polymerase chain reaction (PCR) techniques indicate that at least half of all infections in maternal venous blood are missed by light microscopy or rapid diagnostic tests. The impact of these subpatent infections on maternal and birth outcomes remains unclear.

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Modelling reactive case detection strategies for interrupting transmission of Plasmodium falciparum malaria

August 5, 2019 - 16:20 -- Open Access
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Author(s): 
Theresa Reiker, Nakul Chitnis and Thomas Smith
Reference: 
Malaria Journal 2019 18:259, 30 July 2019

As areas move closer to malaria elimination, a combination of limited resources and increasing heterogeneity in case distribution and transmission favour a shift to targeted reactive interventions. Reactive case detection (RCD), the following up of additional individuals surrounding an index case, has the potential to target transmission pockets and identify asymptomatic cases in them. Current RCD implementation strategies vary, and it is unclear which are most effective in achieving elimination.

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Signatures of divergent anti-malarial treatment responses in peripheral blood from adults and young children in Malawi

June 24, 2019 - 15:58 -- Open Access
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Author(s): 
Paul L. Maurizio, Hubaida Fuseini, Gerald Tegha, Mina Hosseinipour and Kristina De Paris
Reference: 
Malaria Journal 2019 18:205, 24 June 2019

Heterogeneity in the immune response to parasite infection is mediated in part by differences in host genetics, gender, and age group. In infants and young children, ongoing immunological maturation often results in increased susceptibility to infection and variable responses to drug treatment, increasing the risk of complications. Even though significant age-associated effects on host cytokine responses to Plasmodium falciparum infection have been identified, age-associated effects on uncomplicated malaria infection and anti-malarial treatment remain poorly understood.

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Long-lasting insecticidal nets and indoor residual spraying may not be sufficient to eliminate malaria in a low malaria incidence area: results from a cluster randomized controlled trial in Ethiopia

April 22, 2019 - 12:33 -- Open Access
Author(s): 
Eskindir Loha, Wakgari Deressa, Bernt Lindtjørn, et al.
Reference: 
Malaria Journal 2019 18:141, 18 April 2019

The clinical malaria incidence and anaemia prevalence were similar in the four study groups.

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NOT Open Access | Plasmodium falciparum malaria during term pregnancy in Yaounde: a cohort study

February 19, 2019 - 15:48 -- NOT Open Access
Author(s): 
V. Mve Koh, F. Essiben, C. Noa Ndoua, H. Boayeteck Ehete, E.T. Mboudou
Reference: 
Publié dans Médecine d'Afrique Noire 6601 - Janvier 2019 - pages 13-22

The incidence of malaria during term pregnancy was unexpectedly low, but still increased severe fetal and neonatal complications, thus advocating the administration of at least three doses of SMP, started before the 20th week of pregnancy.

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Malaria in Meghalaya: a systematic literature review and analysis of data from the National Vector-Borne Disease Control Programme

November 7, 2018 - 15:06 -- Open Access
Author(s): 
Anne Kessler, Anna Maria van Eijk, Limalemla Jamir, Catherine Walton, Jane M. Carlton and Sandra Albert
Reference: 
Malaria Journal 2018 17:411, 6 November 2018

Like malaria in mainland India, malaria in Meghalaya is complex, with both Plasmodium falciparum and Plasmodium vivax parasites in circulation, multiple Anopheles vector species, and reports of both unusual and severe malaria syndromes across all age groups.

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Steered molecular dynamics simulations reveal critical residues for (un)binding of substrates, inhibitors and a product to the malarial M1 aminopeptidase

November 7, 2018 - 14:38 -- Open Access
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Author(s): 
Daniel S. Moore, Conor Brines, Heather Jewhurst, John P. Dalton, Irina G. Tikhonova
Reference: 
PLoS Comput Biol 14(10): e1006525

Malaria is a life-threatening disease spread by mosquitoes.

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“Wherever doctors cannot reach, the sunshine can”: overcoming potential barriers to malaria elimination interventions in Haiti

October 31, 2018 - 15:32 -- Open Access
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Author(s): 
Thomas Druetz, Katherine Andrinopoulos, Louis-Marie Boulos, Michaelle Boulos, Gregory S. Noland, Luccene Desir, Jean Frantz Lemoine and Thomas P. Eisele
Reference: 
Malaria Journal 2018 17:393, 29 October 2018

There are several potential barriers and opportunities to implement community-based malaria elimination interventions in rural Haiti.

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Chloroquine resistance is associated to multi-copy pvcrt-o gene in Plasmodium vivax malaria in the Brazilian Amazon

July 17, 2018 - 15:59 -- Open Access
Author(s): 
Siuhelem Rocha Silva, Anne Cristine Gomes Almeida, Gisely Cardoso de Melo, et al.
Reference: 
Malaria Journal 2018 17:267, 16 July 2018

This was the first study with 42-day clinical follow-up to evaluate the variation of the number of copies and polymorphisms in the promoter region of the pvcrt-o and pvmdr1 genes in relation to treatment outcomes.

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