The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10206 malaria professionals are enjoying the free benefits of MalariaWorld today

Plasmodium falciparum

The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate

November 11, 2019 - 16:13 -- Open Access
Author(s): 
Shwu-Maan Lee, Yimin Wu, John M. Hickey, Kazutoyo Miura, Neal Whitaker, Sangeeta B. Joshi, David B. Volkin, C. Richter King and Jordan Plieskatt
Reference: 
Malaria Journal 2019 18:356, 8 November 2019

Control and elimination of malaria can be accelerated by transmission-blocking interventions such as vaccines. A surface antigen of Plasmodium falciparum gametocytes, Pfs230, is a leading vaccine target antigen, and has recently progressed to experimental clinical trials. To support vaccine product development, an N-terminal Pfs230 antigen was designed to increase yield, as well as to improve antigen quality, integrity, and homogeneity.

Medical Condition: 

NOT Open Access | Kinetic Driver of Antibacterial Drugs against Plasmodium falciparum and Implications for Clinical Dosing

October 28, 2019 - 16:27 -- NOT Open Access
Author(s): 
Emily Caton, Elizabeth Nenortas, Rahul P. Bakshi and Theresa A. Shapiro
Reference: 
Antimicrob. Agents Chemother. November 2019 63:e00416-19

Antibacterial drugs are an important component of malaria therapy. We studied the interactions of clindamycin, tetracycline, chloramphenicol, and ciprofloxacin against Plasmodium falciparum under static and dynamic conditions.

Medical Condition: 

K13-propeller gene polymorphisms of Plasmodium falciparum and the therapeutic effect of artesunate among migrant workers returning to Guangxi, China (2014–2017)

October 22, 2019 - 16:36 -- Open Access
Author(s): 
Jun Li, Yunliang Shi, Jian Qin, et al.
Reference: 
Malaria Journal 2019 18:349, 16 October 2019

The resistance of Plasmodium falciparum to artemisinin has been identified in Asia and some parts of Africa. The drug resistance of P. falciparum will be an obstacle to the successful elimination of malaria by 2025. Whole-genome sequencing of the artemisinin-resistant parasite line revealed mutations on the k13 gene associated with drug resistance in P. falciparum. To understand the artemisinin resistance of the imported P. falciparum cases from Africa, the mutations in the k13 gene in parasites from imported malaria cases in Guangxi Province were detected and the treatment efficiency of artesunate monotherapy was observed.

Country: 
Medical Condition: 
Medical Treatment: 

Structural insights into diverse modes of ICAM-1 binding by Plasmodium falciparum-infected erythrocytes

October 8, 2019 - 15:36 -- Open Access
Author(s): 
Frank Lennartz, Cameron Smith, Alister G. Craig, and Matthew K. Higgins
Reference: 
PNAS October 1, 2019 116 (40) 20124-20134

A major determinant of pathogenicity in malaria caused by Plasmodium falciparum is the adhesion of parasite-infected erythrocytes to the vasculature or tissues of infected individuals.

Medical Condition: 

Analysis of Plasmodium falciparum Pfcrt and Pfmdr1 genes in parasite isolates from asymptomatic individuals in Southeast Nigeria 11 years after withdrawal of chloroquine

October 8, 2019 - 15:12 -- Open Access
Author(s): 
Moses N. Ikegbunam, Charles N. Nkonganyi, Bolaji N. Thomas, Charles O. Esimone, Thirumalaisamy P. Velavan and Olusola Ojurongbe
Reference: 
Malaria Journal 2019 18:343, 7 October 2019

A reversal of chloroquine (CQ) resistance following a period of withdrawal has raised the possibility of its re-introduction. This study evaluated the current prevalence of Pfcrt and Pfmdr1 alleles in Plasmodium falciparum isolates, 11 years after CQ withdrawal in Southeast Nigeria.

Country: 
Medical Condition: 

Uptake of a fluorescently tagged chloroquine analogue is reduced in CQ-resistant compared to CQ-sensitive Plasmodium falciparum parasites

October 8, 2019 - 15:03 -- Open Access
Author(s): 
Sarah J. Reiling and Petra Rohrbach
Reference: 
Malaria Journal 2019 18:342, 7 October 2019

Chloroquine (CQ) was the drug of choice for decades in the treatment of falciparum malaria until resistance emerged. CQ is suggested to accumulate in the parasite’s digestive vacuole (DV), where it unfolds its anti-malarial properties. Discrepancies of CQ accumulation in CQ-sensitive (CQS) and CQ-resistant (CQR) strains are thought to play a significant role in drug susceptibility. Analysis of CQ transport and intracellular localization using a fluorescently tagged CQ analogue could provide much needed information to distinguish susceptible from resistant parasite strains. The fluorescently tagged CQ analogue LynxTag-CQ™GREEN (CQGREEN) is commercially available and was assessed for its suitability.

Medical Condition: 

Detection of malaria parasites in dried human blood spots using mid-infrared spectroscopy and logistic regression analysis

October 8, 2019 - 15:00 -- Open Access
Author(s): 
Emmanuel P. Mwanga, Elihaika G. Minja, Fredros O. Okumu, et al.
Reference: 
Malaria Journal 2019 18:341, 7 October 2019

Epidemiological surveys of malaria currently rely on microscopy, polymerase chain reaction assays (PCR) or rapid diagnostic test kits for Plasmodium infections (RDTs). This study investigated whether mid-infrared (MIR) spectroscopy coupled with supervised machine learning could constitute an alternative method for rapid malaria screening, directly from dried human blood spots.

Country: 
Medical Condition: 

Genetic polymorphism of the N-terminal region in circumsporozoite surface protein of Plasmodium falciparum field isolates from Sudan

October 7, 2019 - 15:17 -- Open Access
Author(s): 
Nouh S. Mohamed, Musab M. Ali Albsheer, Mohamed M. Elbasheir, et al.
Reference: 
Malaria Journal 2019 18:333, 1 October 2019

Malaria caused by Plasmodium falciparum parasite is still known to be one of the most significant public health problems in sub-Saharan Africa. Genetic diversity of the Sudanese P. falciparum based on the diversity in the circumsporozoite surface protein (PfCSP) has not been previously studied. Therefore, this study aimed to investigate the genetic diversity of the N-terminal region of the pfcsp gene.

Country: 
Medical Condition: 

NOT Open Access | Plasmodium helical interspersed subtelomeric family—an enigmatic piece of the Plasmodium biology puzzle

October 1, 2019 - 14:35 -- NOT Open Access
Author(s): 
Vikash Kumar, Ankita Behl, Rachana Sharma, Aanchal Sharma & Rachna Hora
Reference: 
Parasitology Research, October 2019, Volume 118, Issue 10, pp 2753–2766

Plasmodium falciparum (Pf) refurbishes the infected erythrocytes by exporting a myriad of parasite proteins to the host cell.

Medical Condition: 

Evaluation of Plasmodium falciparum MSP10 and its development as a serological tool for the Peruvian Amazon region

September 30, 2019 - 13:28 -- Open Access
Author(s): 
Jorge Bendezu, Elizabeth Villasis, Katherine Torres, et al.
Reference: 
Malaria Journal 2019 18:327, 23 September 2019

Different antigens are needed to characterize Plasmodium falciparum infection in terms of seroreactivity and targets for invasion inhibition, in order to guide and identify the proper use of such proteins as tools for the development of serological markers and/or as vaccine candidates.

Medical Condition: 

Pages

Subscribe to RSS - Plasmodium falciparum