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Plasmodium falciparum

Signatures of divergent anti-malarial treatment responses in peripheral blood from adults and young children in Malawi

June 24, 2019 - 15:58 -- Open Access
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Author(s): 
Paul L. Maurizio, Hubaida Fuseini, Gerald Tegha, Mina Hosseinipour and Kristina De Paris
Reference: 
Malaria Journal 2019 18:205, 24 June 2019

Heterogeneity in the immune response to parasite infection is mediated in part by differences in host genetics, gender, and age group. In infants and young children, ongoing immunological maturation often results in increased susceptibility to infection and variable responses to drug treatment, increasing the risk of complications. Even though significant age-associated effects on host cytokine responses to Plasmodium falciparum infection have been identified, age-associated effects on uncomplicated malaria infection and anti-malarial treatment remain poorly understood.

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Long-lasting insecticidal nets and indoor residual spraying may not be sufficient to eliminate malaria in a low malaria incidence area: results from a cluster randomized controlled trial in Ethiopia

April 22, 2019 - 12:33 -- Open Access
Author(s): 
Eskindir Loha, Wakgari Deressa, Bernt Lindtjørn, et al.
Reference: 
Malaria Journal 2019 18:141, 18 April 2019

The clinical malaria incidence and anaemia prevalence were similar in the four study groups.

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NOT Open Access | Plasmodium falciparum malaria during term pregnancy in Yaounde: a cohort study

February 19, 2019 - 15:48 -- NOT Open Access
Author(s): 
V. Mve Koh, F. Essiben, C. Noa Ndoua, H. Boayeteck Ehete, E.T. Mboudou
Reference: 
Publié dans Médecine d'Afrique Noire 6601 - Janvier 2019 - pages 13-22

The incidence of malaria during term pregnancy was unexpectedly low, but still increased severe fetal and neonatal complications, thus advocating the administration of at least three doses of SMP, started before the 20th week of pregnancy.

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Malaria in Meghalaya: a systematic literature review and analysis of data from the National Vector-Borne Disease Control Programme

November 7, 2018 - 15:06 -- Open Access
Author(s): 
Anne Kessler, Anna Maria van Eijk, Limalemla Jamir, Catherine Walton, Jane M. Carlton and Sandra Albert
Reference: 
Malaria Journal 2018 17:411, 6 November 2018

Like malaria in mainland India, malaria in Meghalaya is complex, with both Plasmodium falciparum and Plasmodium vivax parasites in circulation, multiple Anopheles vector species, and reports of both unusual and severe malaria syndromes across all age groups.

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Steered molecular dynamics simulations reveal critical residues for (un)binding of substrates, inhibitors and a product to the malarial M1 aminopeptidase

November 7, 2018 - 14:38 -- Open Access
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Author(s): 
Daniel S. Moore, Conor Brines, Heather Jewhurst, John P. Dalton, Irina G. Tikhonova
Reference: 
PLoS Comput Biol 14(10): e1006525

Malaria is a life-threatening disease spread by mosquitoes.

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“Wherever doctors cannot reach, the sunshine can”: overcoming potential barriers to malaria elimination interventions in Haiti

October 31, 2018 - 15:32 -- Open Access
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Author(s): 
Thomas Druetz, Katherine Andrinopoulos, Louis-Marie Boulos, Michaelle Boulos, Gregory S. Noland, Luccene Desir, Jean Frantz Lemoine and Thomas P. Eisele
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Malaria Journal 2018 17:393, 29 October 2018

There are several potential barriers and opportunities to implement community-based malaria elimination interventions in rural Haiti.

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Chloroquine resistance is associated to multi-copy pvcrt-o gene in Plasmodium vivax malaria in the Brazilian Amazon

July 17, 2018 - 15:59 -- Open Access
Author(s): 
Siuhelem Rocha Silva, Anne Cristine Gomes Almeida, Gisely Cardoso de Melo, et al.
Reference: 
Malaria Journal 2018 17:267, 16 July 2018

This was the first study with 42-day clinical follow-up to evaluate the variation of the number of copies and polymorphisms in the promoter region of the pvcrt-o and pvmdr1 genes in relation to treatment outcomes.

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A 17-year trend analysis of malaria at Adi Arkay, north Gondar zone, Northwest Ethiopia

April 10, 2018 - 15:44 -- Open Access
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Author(s): 
Habtie Tesfa, Abebe Genetu Bayih and Ayalew Jejaw Zeleke
Reference: 
Malaria Journal 2018 17:155, 6 April 2018

In relative terms, the overall positivity rate of malaria in the area over 17 years showed a significant reduction, but its magnitude as a public health problem is still alarming.

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Comparative Heterochromatin Profiling Reveals Conserved and Unique Epigenome Signatures Linked to Adaptation and Development of Malaria Parasites

March 21, 2018 - 14:48 -- Open Access
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Author(s): 
Sabine A. Fraschka, Michael Filarsky, Till S. Voss, et al.
Reference: 
Cell Host & Microbe, Volume 23, Issue 3, 14 March 2018, Pages 407-420.e8

Heterochromatin-dependent gene silencing is central to the adaptation and survival of Plasmodium falciparum malaria parasites, allowing clonally variant gene expression during blood infection in humans.

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Stabilization of RDT target antigens present in dried Plasmodium falciparum-infected samples for validating malaria rapid diagnostic tests at the point of care

January 9, 2018 - 16:13 -- Open Access
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Author(s): 
Collins Morang’a, Cyrus Ayieko, George Awinda, Rachel Achilla, Caroline Moseti, Bernhards Ogutu, John Waitumbi and Elizabeth Wanja
Reference: 
Malaria Journal 2018 17:10, 8 January 2018

These findings confirm that stabilizing RDT target antigens in dried P. falciparum-infected samples using chemical additives provides field-stable positive controls for malaria RDTs.

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