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Restricted | Whole parasite vaccination approaches for prevention of malaria infection

May 4, 2012 - 14:08 -- Patrick Sampao
Author(s): 
Noah S. Butler, Ashley M. Vaughan, John T. Harty, Stefan H.I. Kappe
Reference: 
Trends in Immunology, Volume 33, Issue 5, May 2012, Pages 247-254

MalariaWorldThis model gave the rationale for development of recombinant and vectored subunit vaccination strategies that have, however, not yet matched whole sporozoite protective efficacy.

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In vivo antimalarial activity of ginseng extracts

February 22, 2011 - 08:07 -- Kabogo Ndegwa
Author(s): 
Han Han, Yan Chen, Hongtao Bi, Li Yu, Chengxin Sun, Shanshan Li, Sylla Alpha Oumar, Yifa Zhou
Reference: 
Pharmaceutical Biology March 2011, Vol. 49, No. 3 Pages 283-289

Protopanaxadiol-type ginsenosides have remarkably suppressive activity during early infection, while acidic ginseng polysaccharides have significant prophylactic activity against malaria by stimulating the immune system.

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Open Access | The 'hidden' burden of malaria: cognitive impairment following infection

December 23, 2010 - 13:43 -- Kabogo Ndegwa
Author(s): 
Fernando SD, Rodrigo C, Rajapakse S
Reference: 
Malaria Journal 2010, 9:366 (20 December 2010)

The burden of post-malaria cognitive impairment is often overlooked. Given the large number of infections occurring worldwide, the magnitude of the problem is likely to be substantial.

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Caspase-12 deficiency enhances cytokine responses but does not protect against lethal Plasmodium yoelii 17XL infection (pages 773–778)

October 16, 2010 - 08:31 -- Kabogo Ndegwa
Author(s): 
J. Miu, M. Saleh, M. M. Stevenson
Reference: 
Parasite Immunology, Volume 32, Issue 11-12, pages 773–778, November/December 2010

To investigate the effect of caspase-12 deficiency on IFN-γ-independent control of blood-stage malaria, we compared lethal Plasmodium yoelii 17XL infection in wild-type C57BL/6J and caspase-12−/− mice. Infected caspase-12−/− mice exhibited higher parasitaemia than WT mice on days 8 and 9 post-inoculation, but all WT and caspase-12−/− mice succumbed by day 10. In addition, infected caspase-12−/− mice had significantly elevated levels of IFN-γ, TNF, IL-18, and IL-10 in sera compared to infected WT mice.

Activity of a Trisubstituted Pyrrole in Inhibiting Sporozoite Invasion and Blocking Malaria Infection

September 21, 2010 - 07:14 -- Kabogo Ndegwa
Author(s): 
Dhruv Panchal and Purnima Bhanot
Reference: 
Antimicrobial Agents and Chemotherapy, October 2010, p. 4269-4274, Vol. 54, No. 10

Malaria infection is initiated by Plasmodium sporozoites infecting the liver. Preventing sporozoite infection would block the obligatory first step of the infection and perhaps reduce disease severity.

Essential Role for IL-27 Receptor Signaling in Prevention of Th1-Mediated Immunopathology during Malaria Infection

August 5, 2010 - 11:56 -- Kabogo Ndegwa
Author(s): 
Emily Gwyer Findlay, Rachel Greig, Jason S. Stumhofer, Julius C. R. Hafalla, J. Brian de Souza, Christiaan J. Saris, Christopher A. Hunter, Eleanor M. Riley, and Kevin N. Couper
Reference: 
The Journal of Immunology, 2010, 185, 2482 -2492

Successful resolution of malaria infection requires induction of proinflammatory immune responses that facilitate parasite clearance; however, failure to regulate this inflammation leads to immune-mediated pathology.

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Open Access | Short Report: An update of malaria infection and anaemia in adults in Buea, Cameroon

May 10, 2010 - 09:21 -- Kabogo Ndegwa
Author(s): 
EN Takem, EA Achidi, PM Ndumbe
Reference: 
BMC Research Notes 2010, 3:121

In adult patients with fever in this setting, malaria parasitaemia contributes to anaemia and is of public health impact. Our results also provide a baseline prevalence for malaria parasitaemia in febrile adults in health units in this setting.

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Open Access | Alpha-tocopherol transfer protein disruption confers resistance to malarial infection in mice

April 20, 2010 - 09:25 -- Kabogo Ndegwa
Author(s): 
Herbas MS, Ueta YY, Ichikawa C, Chiba M, Ishibashi K, Shichiri M, Fukumoto S, Yokoyama N, Takeya M, Xuan X, Arai H, Suzuki H
Reference: 
Malaria Journal 2010, 9:101 (19 April 2010)

Various factors impact the severity of malaria, including the nutritional status of the host. Vitamin E, an intra and extracellular anti-oxidant, is one such nutrient whose absence was shown previously to negatively affect Plasmodium development.

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