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Not Open Access | Low-Level Plasmodium falciparum Blood-Stage Infection Causes Dendritic Cell Apoptosis and Dysfunction in Healthy Volunteers

July 12, 2012 - 07:45 -- Patrick Sampao
Tonia Woodberry, Gabriela Minigo, Kim A. Piera, Fiona H. Amante, Alberto Pinzon-Charry, Michael F. Good, J. Alejandro Lopez, Christian R. Engwerda, James S. McCarthy and Nicholas M. Anstey
J Infect Dis. (2012) 206 (3): 333-340

MalariaWorldThese findings may explain in part the inadequate development of immunity to blood-stage malaria infection.


Open Access | Review: Regulating the Adaptive Immune Response to Blood-Stage Malaria: Role of Dendritic Cells and CD4+Foxp3+ Regulatory T Cells

November 22, 2011 - 14:42 -- Patrick Sampao
Mary M Stevenson, Rebecca Ing, Floriana Berretta, Jenny Miu
Int J Biol Sci 2011; 7:1311-1322

MalariaWorldHere, we review recent findings from our laboratory and others in experimental models of malaria in mice and in Plasmodium-infected humans on the roles of DC and natural regulatory T cells in regulating adaptive immunity to blood-stage malaria.

Medical Condition: 

Open Access | Oral Presentation: A comprehensive survey of protein palmitoylation in late blood-stage Plasmodium falciparum

November 8, 2010 - 14:53 -- Patrick Sampao
Matthew L Jones, Mark O Collins, Jyoti Choudhary, Julian C Rayner
Malaria Journal 2010, 9(Suppl 2):O20 (20 October 2010)

As a reversible modification, palmitoylation is essential for the dynamic regulation of protein function -controlling, in many cases, protein localisation both to and within specific membrane domains, protein stability, and protein activity.

Evidences of protection against blood-stage infection of Plasmodium falciparum by the novel protein vaccine SE36

August 9, 2010 - 13:13 -- Patrick Sampao
Toshihiro H., Hiroki S., et al.
Parasitology International, Volume 59, Issue 3, September 2010, Pages 380-386

We show here that P. falciparum serine repeat antigen 5 (SERA5) is a potential vaccine immunogen. We have constructed a new recombinant molecule of SERA5, namely SE36, based on previously reported SE47′ molecule by removing the serine repeats.

Medical Treatment: 

Immunity to infection: Blood-stage Plasmodium berghei infection leads to short-lived parasite-associated antigen presentation by dendritic cells

April 19, 2010 - 13:09 -- Kabogo Ndegwa
RJ Lundie, LJ Young, GM Davey, JA Villadangos, FR Carbone, WR Heath, BS Crabb
European Journal of Immunology, Volume 9999 Issue 999A

Despite extensive evidence that Plasmodium species are capable of stimulating the immune system, the association of malaria with a higher incidence of other infectious diseases and reduced responses to vaccination against unrelated pathogens, suggests the existence of immune suppression.

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