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blood-stage

Not Open Access | Low-Level Plasmodium falciparum Blood-Stage Infection Causes Dendritic Cell Apoptosis and Dysfunction in Healthy Volunteers

July 12, 2012 - 07:45 -- Patrick Sampao
Author(s): 
Tonia Woodberry, Gabriela Minigo, Kim A. Piera, Fiona H. Amante, Alberto Pinzon-Charry, Michael F. Good, J. Alejandro Lopez, Christian R. Engwerda, James S. McCarthy and Nicholas M. Anstey
Reference: 
J Infect Dis. (2012) 206 (3): 333-340

MalariaWorldThese findings may explain in part the inadequate development of immunity to blood-stage malaria infection.

Technology: 
Person: 

Open Access | Review: Regulating the Adaptive Immune Response to Blood-Stage Malaria: Role of Dendritic Cells and CD4+Foxp3+ Regulatory T Cells

November 22, 2011 - 14:42 -- Patrick Sampao
Author(s): 
Mary M Stevenson, Rebecca Ing, Floriana Berretta, Jenny Miu
Reference: 
Int J Biol Sci 2011; 7:1311-1322

MalariaWorldHere, we review recent findings from our laboratory and others in experimental models of malaria in mice and in Plasmodium-infected humans on the roles of DC and natural regulatory T cells in regulating adaptive immunity to blood-stage malaria.

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Open Access | Oral Presentation: A comprehensive survey of protein palmitoylation in late blood-stage Plasmodium falciparum

November 8, 2010 - 14:53 -- Patrick Sampao
Author(s): 
Matthew L Jones, Mark O Collins, Jyoti Choudhary, Julian C Rayner
Reference: 
Malaria Journal 2010, 9(Suppl 2):O20 (20 October 2010)

As a reversible modification, palmitoylation is essential for the dynamic regulation of protein function -controlling, in many cases, protein localisation both to and within specific membrane domains, protein stability, and protein activity.

Evidences of protection against blood-stage infection of Plasmodium falciparum by the novel protein vaccine SE36

August 9, 2010 - 13:13 -- Patrick Sampao
Author(s): 
Toshihiro H., Hiroki S., et al.
Reference: 
Parasitology International, Volume 59, Issue 3, September 2010, Pages 380-386

We show here that P. falciparum serine repeat antigen 5 (SERA5) is a potential vaccine immunogen. We have constructed a new recombinant molecule of SERA5, namely SE36, based on previously reported SE47′ molecule by removing the serine repeats.

Medical Treatment: 

Immunity to infection: Blood-stage Plasmodium berghei infection leads to short-lived parasite-associated antigen presentation by dendritic cells

April 19, 2010 - 13:09 -- Kabogo Ndegwa
Author(s): 
RJ Lundie, LJ Young, GM Davey, JA Villadangos, FR Carbone, WR Heath, BS Crabb
Reference: 
European Journal of Immunology, Volume 9999 Issue 999A

Despite extensive evidence that Plasmodium species are capable of stimulating the immune system, the association of malaria with a higher incidence of other infectious diseases and reduced responses to vaccination against unrelated pathogens, suggests the existence of immune suppression.

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