This work confirms the presence of the two species in the same country for the first time, in the Ivory Coast and the Comoros Islands.
In this study, expression of the putative dhfr-ts of Plasmodium ovale rescued the DHFR chemical knockout and a TS null bacterial strain, demonstrating its DHFR and TS catalytic functions.
Recent data have found that Plasmodium ovale can be separated in two distinct species: classic and variant P. ovale based on multilocus typing of different genes.
Plasmodium ovale malaria is currently a problem to diagnose in travellers, notably in French soldiers returning from the Ivory Coast.
This test demonstrated excellent sensitivity and specificity, and adds P. knowlesi to the repertoire of Plasmodium targets for the clinical diagnosis of malaria by real-time PCR assays.
Relapsing human malaria is regarded to be caused by Plasmodium vivax and Plasmodium ovale. P. vivax relapses originate from dormant liver stages: “hypnozoites”. Also, P. ovale, a species considered as closely related to P. vivax, is in analogy assumed to display hypnozoites.
We present some recent data from surveys in several African localities as well as analyses of Malaria Reference Laboratory data for patterns of presentation of these parasite species among imported malaria cases in the UK, and consider the possibility that a substantial hidden burden of infection exists.
The splenic complications of acute malaria include two different prognostic and treatment entities: splenic infarction and splenic rupture.
The current finding should serve as an alert to epidemiologists, clinicians and laboratory technicians in the possibility of finding P. ovale in Malaysia.
The merozoite surface protein 1 (MSP1) is the principal surface antigen of the blood stage form of the Plasmodium parasite. Antibodies recognizing MSP1 are frequently detected following Plasmodium infection, making this protein a significant component of malaria vaccines and diagnostic tests.