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dihydrofolate reductase

Open Access | Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model

May 11, 2011 - 12:26 -- Patrick Sampao
Wachiraporn Tipsuwan, Somdet Srichairatanakool, Sumalee Kamchonwongpaisan, Yongyuth Yuthavong, Chairat Uthaipibull
Malaria Journal 2011, 10:119 (10 May 2011)

This study demonstrated the power of the transgenic P. berghei system to predict drug-resistant Pfdhfr mutations in an in vivo parasite/host setting.

Mutations in the Antifolate-Resistance-Associated Genes Dihydrofolate Reductase and Dihydropteroate Synthase in Plasmodium vivax Isolates from Malaria-Endemic Countries

September 2, 2010 - 13:51 -- Patrick Sampao
Feng L., Chae S., et al.
Am. J. Trop. Med. Hyg., 83(3), 2010, pp. 474-479

We sequenced the Plasmodium vivax dihydrofolate reductase (pvdhfr) and dihydropteroate synthase (pvdhps) genes to examine the prevalence and extent of point mutations in isolates from malaria-endemic countries.

Plasmodium falciparum Dihydrofolate Reductase and Dihyropteroate Synthase Mutations and the Use of Trimethoprim-Sulfamethoxazole Prophylaxis among Persons Infected with Human Immunodeficiency Virus

May 4, 2010 - 14:19 -- Patrick Sampao
Samuel Malamba, Taylor Sandison, John Lule, Arthur Reingold, Jordan Walker, Grant Dorsey, AND Jonathan Mermin
Am J Trop Med Hyg, May 2010; 82: 766 - 771.

Although resistance rates of P. falciparum to antifolate drugs are high, cotrimoxazole-prophylaxis in HIV-infected persons was not associated with a higher prevalence of mutations associated with antifolate resistance. 

Transmission and Cross-Mating of High-Level Resistance Plasmodium falciparum Dihydrofolate Reductase Haplotypes in The Gambia

April 13, 2010 - 09:05 -- Patrick Sampao
Amani Kheir, Davis Nwakanma, Aisha Al-Gazali, Yagut Akbarova, Salma Al-Saai, Göte Swedberg, AND Hamza A. Babiker
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 535-541

Similarities were seen between pfg377 and MSP-1 alleles in children and mosquitoes and evidence of cross-mating between different parasite genotypes was seen in some infected mosquitoes, reflecting high transmission success of existing clones.

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