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Celebral Malaria

Open Access | Plasmodium falciparum parasites causing cerebral malaria share variant surface antigens, but are they specific?

July 29, 2010 - 10:32 -- Kabogo Ndegwa
Author(s): 
Kheliouen N, Viwami F, Lalya F, Tuikue-Ndam N, Eboumbou Moukoko EC, Rogier C, Deloron P, Aubouy A
Reference: 
Malaria Journal 2010, 9:220 (27 July 2010)

In conclusion, this study suggests the existence of serologically distinct VSACM and VSAUM. CM isolates were shown to share common epitopes. Specific antibody response to VSAUM was predominant, suggesting a relative low diversity of VSAUM in the study area.

Open Access | Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria

July 21, 2010 - 10:14 -- Kabogo Ndegwa
Author(s): 
Dell'Agli M, Galli GV, Bulgari M, Basilico N, Romeo S, Bhattacharya D, Taramelli D, Bosisio E
Reference: 
Malaria Journal 2010, 9:208 (19 July 2010)

The beneficial effect of the fruit rind of Punica granatum for the treatment of malarial disease may be attributed to the anti-parasitic activity and the inhibition of the pro-inflammatory mechanisms involved in the onset of cerebral malaria.

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Natural regulatory T cells mediate the development of cerebral malaria by modifying the pro-inflammatory response

May 5, 2010 - 07:48 -- Patrick Sampao
Author(s): 
Jing-jing Wu, Guang Chen, Jun Liu, Tao Wang, Wei Zheng, Ya-Ming Cao
Reference: 
Parasitology International, Volume 59, Issue 2, June 2010, Pages 232-241

Our data demonstrate that Tregs mediate the incidence and outcome of CM in P.bANKA-infected mice by modifying the pro-inflammatory response.

Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease

April 21, 2010 - 09:48 -- Kabogo Ndegwa
Author(s): 
J. Brian de Souza, Julius C. R. Hafalla, Eleanor M. Riley and Kevin N. Couper
Reference: 
Parasitology, Volume 137, Issue 05, April 2010, pp 755-772

Here we review the current understanding of the parasitological and immunological events leading to human and experimental cerebral malaria, and explain why we believe that studies with experimental models of CM are crucial to define the pathogenesis of the condition.

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Open Access | Research: Oral Activated Charcoal Prevents Experimental Cerebral Malaria in Mice and in a Randomized Controlled Clinical Trial in Man Did Not Interfere with the Pharmacokinetics of Parenteral Artesunate

April 16, 2010 - 08:07 -- Kabogo Ndegwa
Author(s): 
J. Brian de Souza, Uduak Okomo,Michael Walther, et al.
Reference: 
PLoS ONE 5(4): e9867

If future studies succeed in establishing the efficacy of oAC in human malaria, then the characteristics of being inexpensive, well-tolerated at high doses and requiring no sophisticated storage would make oAC a relevant candidate for adjunct therapy to reduce mortality from severe malaria, or for immediate treatment of suspected severe malaria in a rural setting.

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TLR9 Polymorphisms Are Associated with Altered IFN-{gamma} Levels in Children with Cerebral Malaria

April 13, 2010 - 08:32 -- Patrick Sampao
Author(s): 
Nadia A. Sam-A., Jennifer A. G., et al
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 548-555

We present the first human data that TLR SNPs are associated with altered cytokine production in parasitic infection.

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