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Celebral Malaria

Autoantibody against dendrite in Plasmodium falciparum infection: A singular auto-immune phenomenon preferentially in cerebral malaria

March 23, 2011 - 08:17 -- Kabogo Ndegwa
Author(s): 
Sébastien Gallien, Christian Roussilhon, Catherine Blanc, Jean-Louis Pérignon, Pierre Druilhe
Reference: 
Acta Tropica, Volume 118, Issue 1, April 2011, Pages 67-70

To investigate auto-reactive antibodies against dendrites of neurons (AAD) previously reported in cerebral malaria (CM) for their functional biological activity, a serological study was conducted in a larger cohort of patients with CM and uncomplicated falciparum malaria (UM).

Open Access | Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria

March 2, 2011 - 11:15 -- Kabogo Ndegwa
Author(s): 
Bernardo S. Franklin, Sally T. Ishizaka, Ricardo T. Gazzinelli, et al.
Reference: 
PNAS March 1, 2011 vol. 108 no. 9 3689-3694

Excessive release of proinflammatory cytokines by innate immune cells is an important component of the pathogenic basis of malaria.

Developmental outcomes in Malawian children with retinopathy-positive cerebral malaria

February 23, 2011 - 09:57 -- Kabogo Ndegwa
Author(s): 
Michael J. Boivin, Melissa J. Gladstone, Maclean Vokhiwa, Gretchen L. Birbeck, Jed G. Magen, Connie Page, Margaret Semrud-Clikeman, Felix Kauye and Terrie E. Taylor
Reference: 
Tropical Medicine & International Health, Volume 16, Issue 3, pages 263–271, March 2011

Children who suffer retinopathy-positive CM at preschool age are at greater risk of developmental delay, particularly with respect to language development.

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Open Access| Protein Kinase C-Theta Is Required for Development of Experimental Cerebral Malaria

January 27, 2011 - 06:18 -- Kabogo Ndegwa
Author(s): 
Mathilde Fauconnier, Marie-Laure Bourigault, Valerie F.J. Quesniaux, et al.
Reference: 
The American Journal of Pathology, Volume 178, Issue 1 , Pages 212-221, January 2011

Cerebral malaria is the most severe neurologic complication in children and young adults infected with Plasmodium falciparum.

The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology

January 18, 2011 - 06:30 -- Kabogo Ndegwa
Author(s): 
Pierre A. Buffet, Innocent Safeukui, Guillaume Deplaine, Valentine Brousse, Virginie Prendki, Marc Thellier, Gareth D. Turner, and Odile Mercereau-Puijalon
Reference: 
Blood, 13 January 2011, Vol. 117, No. 2, pp. 381-392

Clinical manifestations of Plasmodium falciparum infection are induced by the asexual stages of the parasite that develop inside red blood cells (RBCs).

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Open Access | Pentoxifylline as an adjunct therapy in children with cerebral malaria

December 23, 2010 - 13:55 -- Kabogo Ndegwa
Author(s): 
Lell B, Kohler C, Wamola B, Olola CH, Kivaya E, Kokwaro G, Wypij D, Mithwani S, Taylor TE, Kremsner PG, Newton CR
Reference: 
Malaria Journal 2010, 9:368 (21 December 2010)

The small sample size does not permit definitive conclusions, but the mortality rate was unexpectedly high in the PTX group.

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Development of experimental cerebral malaria is independent of IL-23 and IL-17

December 1, 2010 - 04:44 -- Kabogo Ndegwa
Author(s): 
Hidekazu Ishida, Chikako Matsuzaki-Moriya, Hajime Hisaeda, et al.
Reference: 
Biochemical and Biophysical Research Communications, Volume 402, Issue 4, 26 November 2010, Pages 790-795

Cerebral malaria (CM) is the most severe complication of Plasmodium infection. Although inappropriate immune responses to Plasmodium falciparum are reported as the major causes of CM, the precise mechanisms for development remain unclear.

Open Access | Elevated Cell-Specific Microparticles Are a Biological Marker for Cerebral Dysfunctions in Human Severe Malaria

October 22, 2010 - 14:20 -- Kabogo Ndegwa
Author(s): 
Joël Bertrand Pankoui Mfonkeu, Inocent Gouado, Honoré Fotso Kuaté, Odile Zambou, Paul Henri Amvam Zollo, Georges Emile Raymond Grau, Valéry Combes
Reference: 
PLoS ONE 5(10): e13415

Cerebral malaria (CM) and severe anemia (SA) are the most severe complications of Plasmodium falciparum infections.

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Open Access | The age patterns of severe malaria syndromes in sub-Saharan Africa across a range of transmission intensities and seasonality settings

October 17, 2010 - 08:41 -- Kabogo Ndegwa
Author(s): 
Roca-Feltrer A, Carneiro I, Smith L, Armstrong Schellenberg JR, Greenwood B, Schellenberg D
Reference: 
Malaria Journal 2010, 9:282 (13 October 2010)

Although the peak age of CM will increase as transmission intensity decreases in Africa, more than 75% of all paediatric hospital admissions of severe malaria are likely to remain in under five year olds in most epidemiological settings.

Rethinking cerebral malaria pathology

August 30, 2010 - 06:27 -- Kabogo Ndegwa
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Author(s): 
Milner, Danny A Jr
Reference: 
Current Opinion in Infectious Diseases: October 2010 - Volume 23 - Issue 5 - p 456–463

As we close the gaps in the fight against global malaria, the question of cerebral malaria mortality remains a source of great concern.

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