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immune

Review: Harnessing immune responses against Plasmodium for rational vaccine design

June 1, 2011 - 14:07 -- Patrick Sampao
Author(s): 
Bruno Douradinha, Denise L. Doolan
Reference: 
Trends in Parasitology, Volume 27, Issue 6, June 2011, Pages 274-283

In this review, we discuss the latest developments in the field and speculate on how immune responses against Plasmodium could be harnessed for rational vaccine design and application.

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Brief report: Divergent Roles of IRAK4-Mediated Innate Immune Responses in Two Experimental Models of Severe Malaria

July 2, 2010 - 13:33 -- Patrick Sampao
Author(s): 
Constance A. M. Finney, Ziyue Lu, Michael Hawkes, Wen-Chen Yeh, W. Conrad Liles, AND Kevin C. Kain
Reference: 
Am J Trop Med Hyg, Jul 2010; 83: 69 - 74.

These results show that IRAK4-mediated innate immune inflammatory responses play critical roles in divergent clinical outcomes in murine malaria models.

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